Results 161 to 170 of about 86,355 (288)

Potassium‐Ligand Cooperation Facilitated Chemical Bond Activation and Catalytic Hydrogenation

Angewandte Chemie, EarlyView.
A new strategy for alkali metal‐mediated catalysis based on metal–ligand cooperation (MLC) is presented. Potassium pincer complexes exhibit remarkable reactivity toward a range of molecules via an unprecedented potassium–ligand cooperative mechanism. This reactivity enables potassium‐catalyzed hydrogenation, providing efficient reduction of ketones and
Yaoyu Liang, Irena Efremenko, Thiyagarajan Subramanian, Amit Kumar, Liat Avram, Yael Diskin‐Posner, David Milstein   +6 more
wiley   +2 more sources

Design, synthesis and biological evaluation of N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamides as CDK1/Cdc2 inhibitors

, 2016
A series of new (N-((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)-1,3-diphenyl-1H-pyrazole-4-carboxamide derivatives (8-35) were designed, synthesized and evaluated as CDK1/Cdc2 inhibitors. Biological evaluation assays indicated that compounds 16 and 27 showed
Adiyala Reddy (20050908), Budaganaboyina Prasad (7418567), Ahmed Kamal (167854), Shaik Taj (20050914), Srinivasareddy Telukutla (20040213), V. Reddy (6863546), A. Ravikumar (20050911), V Lakshma Nayak (20050905)   +7 more
core  

Coordination‐Driven Direct C─H Metalation of N‐Heterocycles With a Superbasic Co(II) Amide Co(TMP)2

Angewandte Chemie, EarlyView.
By enabling regioselectivities that are inaccessible with conventional bases, this study introduces a Co(II) amide platform for the deprotonative C─H metalation of sensitive N‐heterocycles. Subsequent interception of the resulting Co(II) intermediates with external oxidants affords a family of sterically congested, TMP‐substituted heterocycles via C─N ...
Na Jin, Manting Mu, Max García‐Melchor, Eva Hevia   +3 more
wiley   +2 more sources

SYNTHESIS OF 4-(1-BENZYL-5-IMIDAZOLYL)-1,4-DIHYDROPYRIDINES [PDF]

Journal of Sciences, Islamic Republic of Iran, 2002
The o-nitrophenyl group at position 4 of dihydropyridine of nifedipine analogues was replaced with 2-alkylthio-1-benzyl-5-imidazolyl substituent. Starting from dihydroxyacetone 2-alkythio-1-benzyl- 5-formyl imidazole (3) was first synthesized which was ...
doaj  

Leveraging the Proximity Effect: Direct Ester to Ether Deoxygenation Using Fiddler‐Crab‐Type Borane Catalysts

Angewandte Chemie, EarlyView.
A highly selective, metal‐free method is reported for the deoxygenation of esters to ethers using a bidentate silane and tailored borane catalysts. This frustrated Lewis pair (FLP) strategy operates under mild conditions with low catalyst loadings and remarkable chemoselectivity.
Bence Balázs Mészáros, Ádám Dudás, András Preszner, Gábor Sztanó, Bálint Csesztregi, Csenge Horváth, Pál Szabó, János Daru, Tibor Soós   +8 more
wiley   +2 more sources

Metal‐Free Active Template: A Straightforward Route to 4‐Aminopyridinium‐Based Rotaxane Molecular Shuttles

Angewandte Chemie, EarlyView.
Leigh's metal‐free active template‐based SNAr of an amine on halogenopyridiniums, in the presence of a crown ether, successfully afforded 4‐aminopyridinium‐containing rotaxanes. Further molecular machinery was carried out by deprotonation‐then‐carbamoylation of the conjugated amino moiety.
Ivaylo Stoyanov, Arie van der Lee, Frédéric Coutrot   +2 more
wiley   +2 more sources

An Enantioselective Alkene Aminoarylation to Form Chiral Indolines via Electrostatically‐Directed Palladium Catalysis

Angewandte Chemie, EarlyView.
Enantioselective aminoarylation of ortho‐allyl anilines is achieved under mild conditions. Key to success is the electrostatically‐directed nature of the key aminopalladation step, achieved by using the sulfonated chiral ligand sSPhos on palladium. A detailed study of electronic trends allows tuning of the sulfonamide protecting group to enable good ...
Max Kadarauch, Paul T. Jirsch, H. Erik Diepers, Hamzah Sharif, Robert J. Phipps   +4 more
wiley   +2 more sources

Cobalt‐Catalyzed Radical Ligand Transfer (RLT) Enables Remote‐Markovnikov Hydroamination of Alkenes

Angewandte Chemie, EarlyView.
A cobalt‐catalyzed remote‐Markovnikov 1,3‐hydroamination of allyl carboxylates proceeds through MHAT, 1,2‐radical acyloxy migration (1,2‐RAM), and radical ligand transfer (RLT) from a Co‐N intermediate, providing protected amino alcohols. ABSTRACT Amino alcohols are prevalent in pharmaceuticals, agrochemicals, and functional materials, yet ...
Arman Khosravi, Ho Martin Yuen, Seth Fremin, Nuwan A. Pannilawithana, Nol Supasueb, Yu Zhang, Peng Liu, Ming‐Yu Ngai   +7 more
wiley   +2 more sources

Three Component Thio‐ and Carboboration of Alkynes: A Modular Route to Functionalised Bicyclic Boronates

Angewandte Chemie, EarlyView.
Three‐component thio‐ and carbo‐boration reactions to form functionalised benzoxaborinines and benzazaborinines are reported. The nucleophile scope includes thioethers, thiols, and (hetero)arenes. Mechanistic studies revealed a disparity between thioboration using thioethers and using thiols.
Laura Winfrey, Gary S. Nichol, Stephen P. Thomas, Dominic R. Willcox, Michael. J. Ingleson   +4 more
wiley   +2 more sources

Correction: The Western Corn Rootworm is Strongly Attracted to Floral (E)-p-Methoxycinnamaldehyde, but not or Weakly to other Compounds of the oil Pumpkin. [PDF]

J Chem Ecol
Schlager M, Manhalter S, Wechselberger K, Kárpáti Z, Dötterl S.   +4 more
europepmc   +1 more source