Results 171 to 180 of about 77,454 (243)

Synthesis and Activity‐Based Protein Profiling Identifies Aldo‐Keto Reductase 1C3 as Target Protein of Myxoglucamides

Angewandte Chemie International Edition, EarlyView.
Myxoglucamide A—a novel glycolipopeptide isolated from myxobacteria—was synthesized, and activity‐based protein profiling identified aldo‐keto reductase 1C3 (AKR1C3) as its main target in human cells. Structure‐activity relationship studies, together with biophysical characterization and X‐ray crystallography, elucidated the structural basis of AKR1C3 ...
Thomas Siemon, Vivek K. Mishra, Mingming Zhao, Konrad Büssow, Alexander Popoff, Chengzhang Fu, Rolf Müller, Lothar Jänsch, Wulf Blankenfeldt, Mark Brönstrup   +9 more
wiley   +1 more source

Discovery of TYR inhibitors from de novo molecular generation to dual-track lead optimization: "Competition" between AI and chemists. [PDF]

Sci Adv
Sun Y, Wang J, Chen W, Jiang X, Wang S, Zhi J, Li F, Feng M, Niu X, Ju B, Guo J, Bai R.   +11 more
europepmc   +1 more source

Evaluation of electrophysiological responses of bumblebee pollinators to floral scents of oil pumpkin

Barman M, Tenhaken R, Dötterl S.
europepmc   +1 more source

(N)-Methanocarba Adenosine Derivatives as Dual Modulators of P-Glycoprotein and ABCG2 Transporters. [PDF]

J Med Chem
Murakami M, Tosh DK, Salazar PB, Jacobson KA, Ambudkar SV.   +4 more
europepmc   +1 more source

Synergistic attraction: Development and field evaluation of a multicomponent lure for Zeugodacus cucurbitae based on host-plant volatiles and gut bacterium-derived volatiles. [PDF]

Pest Manag Sci
Li J, Chen G, Yue Y, Wang J, Liu Y, Tian Z, Yang J, Zhang B, Zhou Z.   +8 more
europepmc   +1 more source

French Propolis Caffeic Acid Derivatives Protect Skeletal Muscle from Oxidative Damages. [PDF]

Biomolecules
Portillo-Lemus L, Vernus B, Chabi B, Lebrun A, Cazals G, Rapior S, Fons F, Carnac G, Morel S.   +8 more
europepmc   +1 more source

Evaluation of Photophysical Properties and Biological Applications of Diarylmethanes. [PDF]

ChemistryOpen
Jenifer HR, Singh FV, Balamurali MM.
europepmc   +1 more source

Synthesis, Characterization, and Biological Evaluation of Noble Metal Complexes with 2‑(1-Benzyl‑1<i>H</i>‑1,2,3-triazol-4-yl)pyridine Ligand: An Interesting Class of Metallo-antimicrobial and -antitumor Agents. [PDF]

ACS Omega
Giunta D, Solinas M, Canu B, Pilo MI, Scano A, Orrù G, Fais S, Pichiri G, Zucca A.   +8 more
europepmc   +1 more source

Biological activity of 2-methylbenzimidazole derivatives with heterocyclic rings on development of <i>Bombyx mori</i>. [PDF]

J Pestic Sci
Gunasekara UKDSS, Inoue K, Tsuchiya W, Kutsuwada K, Henmi S, Shiotsuki T.   +5 more
europepmc   +1 more source

Quaternary Phosphonium Salts Outperformed Vemurafenib (PLX) and Etoposide Against BRAF^V600D,V600E PLX-Resistant Melanoma and MDR Neuroblastoma, Exhibiting No/Low Toxicity on 3T3/HaCaT Cells. [PDF]

Int J Mol Sci
Alfei S, Signorello MG, Tirendi S, Khaledizadeh E, Giordani P, Reggio C, Marengo B, Domenicotti C.   +7 more
europepmc   +1 more source