Results 21 to 30 of about 3,315 (223)

Development and Clinical Application of Positron Emission Tomography Imaging Agents for Monoamine Oxidase B

open access: yesFrontiers in Neuroscience, 2022
Monoamine oxidase B (MAO-B) is a high-density protein in the brain mainly found on outer mitochondrial membranes, primarily in astroglia, but additionally in serotonergic neurons and in the substantia nigra in the midbrain.
Jeffrey H. Meyer   +4 more
doaj   +1 more source

Functional modulation of vascular adhesion protein-1 by a novel splice variant. [PDF]

open access: yesPLoS ONE, 2013
Vascular Adhesion Protein-1 (VAP-1) is an endothelial adhesion molecule belonging to the primary amine oxidases. Upon inflammation it takes part in the leukocyte extravasation cascade facilitating transmigration of leukocytes into the inflamed tissue ...
Sam Kaitaniemi   +5 more
doaj   +1 more source

Synthesis, in vitro enzyme activity and molecular docking studies of new benzylamine-sulfonamide derivatives as selective MAO-B inhibitors

open access: yesJournal of Enzyme Inhibition and Medicinal Chemistry, 2020
Many studies have been conducted on the selective inhibition of human monoamine oxidase B (hMAO-B) enzyme using benzylamine-sulphonamide derivatives. Using various chemical modifications on BB-4h, which was reported previously by our team and showed a ...
Begüm Nurpelin Sağlık   +8 more
doaj   +1 more source

Metabolic Effects of Oral Phenelzine Treatment on High-Sucrose-Drinking Mice [PDF]

open access: yes, 2018
Phenelzine has been suggested to have an antiobesity effect by inhibiting de novo lipogenesis, which led us to investigate the metabolic effects of oral chronic phenelzine treatment in high-sucrose-drinking mice.
Carpéné, Christian   +3 more
core   +2 more sources

Molecular aspects of monoamine oxidase B [PDF]

open access: yes, 2016
Monoamine oxidases (MAO) influence the monoamine levels in brain by virtue of their role in neurotransmitter breakdown. MAO B is the predominant form in glial cells and in platelets.
Ramsay, Rona Ruth
core   +1 more source

Platelet monoamine oxidase activity in alcoholics with and without a family history of alcoholism [PDF]

open access: yes, 2000
A number of studies point at platelet monoamine oxidase (MAO) activity being reduced in alcoholics with a family history of drinking, this being a possible vulnerability marker for alcoholism.
Benda, Ellen   +5 more
core   +1 more source

Characterization of the Covalently Bound Anionic Flavin Radical in Monoamine Oxidase A by Electron Paramagnetic Resonance [PDF]

open access: yes, 2007
It was recently suggested that partially reduced monoamine oxidase (MAO) A contains an equilibrium mixture of an anionic flavin radical and a tyrosyl radical (Rigby, S. E.; et al. J. Biol. Chem. 2005, 280, 4627-4632).
KAY CW   +4 more
core   +1 more source

Systemic oxidative stress is implicated in the pathogenesis of brain edema in rats with chronic liver failure [PDF]

open access: yes, 2012
Chronic liver failure leads to hyperammonemia, a central component in the pathogenesis of hepatic encephalopathy (HE); however, a correlation between blood ammonia levels and HE severity remains controversial. It is believed oxidative stress plays a role
Bosoi, Cristina R.   +6 more
core   +1 more source

Evidence for existence of thyroid hormone inducible semicarbazide-sensitive amine oxidase (SSAO) in rat heart cytosol

open access: yesIndian Heart Journal, 2016
Background: Semicarbazide-sensitive amine oxidase (SSAO; EC; 1.4.3.6.) has widespread tissue distribution, and the physiological role of SSAO is quite well known through its involvement in several pathological states.
Toshio Obata, Michiko Nakashima
doaj   +1 more source

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