Results 51 to 60 of about 3,315 (223)
Clinical Pharmacology in Drug Development, Volume 14, Issue 9, Page 700-709, September 2025.Abstract Berzosertib is a small‐molecule ataxia telangiectasia and Rad3‐related protein inhibitor. To assess the clearance mechanism(s) of berzosertib, a Phase 1, 2‐period, open‐label study was conducted in adults with advanced solid tumors who were treated with a single intravenous dose of 210 mg/m2 berzosertib containing approximately 3 µCi of [14C ...
Jayaprakasam Bolleddula +12 more
wiley +1 more source
PET studies of the serotonin system in major depression and its treatment [PDF]
, 2014 The serotonin system has been implicated in major depression since the 1960s, mainly based on the serotonin enhancing properties of antidepressants.
Tiger, Mikael
core +1 more source
Angewandte Chemie, Volume 137, Issue 7, February 10, 2025.Readily available poly‐(para‐phenylene ethynylene) acts as a strong oxidant under visible light irradiation. This excited‐state reactivity provides a potent manifold to perform heterogeneous photocatalytic oxidation of amines into imines under flow conditions with straightforward photocatalyst recycling. The inline generation of imine can be telescoped
Basile Weyl +7 more
wiley +2 more sources
MONOAMINE OXIDASE A (MAOA), CHILDHOOD TRAUMA, ALCOHOLISM AND AGGRESSION [PDF]
, 2008 Women who have experienced childhood sexual abuse (CSA) have an increased risk of alcoholism and antisocial personality disorder (ASPD). Among males, a functional polymorphism (MAOA-LPR, monoamine oxidase A linked polymorphic region) in the promoter ...
DUCCI, FRANCESCA
core
Protein and cell patterning in closed polymer channels by photoimmobilizing proteins on photografted poly(ethylene glycol) diacrylate [PDF]
, 2014 Definable surface chemistry is essential for many applications of microfluidic polymer systems. However, small cross-section channels with a high surface to volume ratio enhance passive adsorption of molecules that depletes active molecules in solution ...
Larsen, Esben Kjær Unmack +2 more
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Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature [PDF]
, 2017 The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper.
Busardò, F. P +6 more
core
11CO2 Fixation: A Renaissance in PET Radiochemistry [PDF]
, 2013 Carbon-11 labelled carbon dioxide is the cyclotron-generated feedstock reagent for most positron emission tomography (PET) tracers using this radionuclide.
Collier, Thomas L +6 more
core +1 more source
M30 Antagonizes Indoleamine 2,3-Dioxygenase Activation and Neurodegeneration Induced by Corticosterone in the Hippocampus [PDF]
, 2016 Monoamine oxidases (MAO), downstream targets of glucocorticoid, maintain the turnover and homeostasis of monoamine neurotransmitters; yet, its pathophysiological role in monoamine deficiency, oxidative stress and neuroinflammation remains controversial ...
Fung, ML +4 more
core +1 more source
Drug Design, Development and Therapy, 2017 Yuh-Hwa Liu,1,2,* Yeh-Lin Lu,3,* Der-Zen Liu,4 Wen-Chi Hou5 1Division of Gastroenterology, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan; 2Department of General Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan; 3Department
Liu YH, Lu YL, Liu DZ, Hou WC
doaj
Chemistry–Methods, Volume 5, Issue 7, July 2025.This review briefly highlights the construction of charge‐assisted hydrogen‐bonded organic frameworks using a variety of organic acids and organic bases, which feature different hydrogen‐bonding motifs, along with their applications, including negative linear compressibility, proton conduction, atmospheric water harvesting, gas adsorption and ...
Xian‐Xian Xiao +5 more
wiley +1 more source