Results 1 to 10 of about 28,920 (238)
Heliyon, 2023 In recent years, the scientific community has focused on traditional natural products and their potential therapeutic benefits. Berberine is a plant-derived isoquinoline alkaloid with a variety of biological properties and identified as a promising ...
Soheila Alipour Noghabi +3 more
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Protective effects of berberine-loaded chitosan/solid lipid nanoparticles in streptozotocin-induced gestational diabetes mellitus rats [PDF]
Experimental Biology and MedicineBerberine, known as an antioxidant agent, can improve glycemic indices in animal models of diabetes; however, it is clinically limited by poor bioavailability.
Yu Liu, Shaik Althaf Hussain, Hua Yue
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Berberine ameliorates high-fat diet-induced metabolic disorders through promoting gut Akkermansia and modulating bile acid metabolism [PDF]
Chinese MedicineBackground Coptidis Rhizoma, the rhizome of Coptis chinensis Franch., has long been employed in the treatment of diabetes. Its active component, berberine, has been utilized in clinical practice; however, the underlying mechanisms of its protective ...
Wei-jian Hang +5 more
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Berberine and berberrubine promote the expression of CYP3A4 via enhancing the binding of nuclear receptor PXR [PDF]
BMC Pharmacology and ToxicologyBackground Berberine is currently co-administered with statins in clinical practice for hyperlipidemia management. This study aimed to investigate the effects of berberine and berberrubine on CYP3A4 expression and the regulatory mechanism.
Gui-mei Xiao +3 more
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Evaluation of the Potential Role of Silver Nanoparticles Loaded with Berberine in Improving Anti-Tumor Efficiency [PDF]
Pharmaceutical Sciences, 2022 Background: Cancer is a progressive disease, its incidence and death rates are rapidly increasing globally. Numerous adverse effects are associated with the available interventions. Hence, the current study was undertaken to explore the anticancer effect
Mohamed Othman +6 more
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Pharmaceutical Biology, 2022 Context Berberine has myocardial protective effects.Objectives The protective effects of berberine on heart ischemia–reperfusion (I/R) injury were explored.Materials and methods Human cardiomyocytes were divided into control group, oxygen-glucose ...
Xiaojing Jia, Wei Shao, Suqing Tian
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Frontiers in Pharmacology, 2022 Lysyl hydroxylase-2 (LH2) involves in the hydroxylation of telopeptide lysine residues during collagen deposition. Recent studies indicate that interleukin (IL)-6 generated by the chronic inflammation disease may trigger the LH2 expression to accelerate ...
Yishan Du +9 more
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EXCLI Journal : Experimental and Clinical Sciences, 2022 Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a secreted protein and a critical regulator of low-density lipoprotein-cholesterol (LDL-C) through inducing degradation of the LDL receptor (LDLR) within the hepatocyte lysosome. PCSK9 deficiency significantly improves the survival rate of cardiovascular disease (CVDs) patients.
Sarina Ataei +2 more
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Frontiers in Pharmacology, 2023 Berberine is an isoquinoline alkaloid found in plants. It presents a wide range of pharmacological activities, including anti-inflammatory and antioxidant properties, despite a low oral bioavailability.
Tessa Dehau +5 more
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Berberine induces caspase-independent cell death in colon tumor cells through activation of apoptosis-inducing factor. [PDF]
PLoS ONE, 2012 Berberine, an isoquinoline alkaloid derived from plants, is a traditional medicine for treating bacterial diarrhea and intestinal parasite infections. Although berberine has recently been shown to suppress growth of several tumor cell lines, information ...
Lihong Wang +10 more
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