Results 91 to 100 of about 28,920 (238)
Advanced Science, Volume 13, Issue 3, 14 January 2026.Helical nanostructures co‐assembled from berberine (BBR) and Fmoc‐Y display supramolecular‐chirality‐dependent photodynamic antibacterial activity. The molecular chirality of Fmoc‐Y organizes achiral BBR into chiral nanofibers, where supramolecular handedness controls bacterial surface adsorption, membrane penetration, intracellular BBR delivery, and ...
Haoqiang Zhao +9 more
wiley +1 more source
Research Progress of Ferroptosis in Cerebral Infarction
Brain and Behavior, Volume 16, Issue 1, January 2026.Cerebral infarction triggers ischemia–reperfusion injury, leading to iron overload, oxidative stress, and mitochondrial dysfunction, which together initiate ferroptosis—an iron‐dependent, lipid peroxidation–driven form of neuronal death. Disruption of the System Xc−/GSH/GPX4 antioxidant axis and ACSL4‐mediated PUFA phospholipid enrichment accelerates ...
Yilan Fei, Qi Leng
wiley +1 more source
The Potential of Phytochemicals to Overcome Multidrug Resistance in Metastatic Melanoma
Chemistry &Biodiversity, Volume 23, Issue 1, January 2026.ABSTRACT Metastatic melanoma is the most lethal form of skin cancer, accounting for most skin cancer‐related deaths. Immunotherapies and targeted therapies have improved overall and progression‐free survival rates in metastatic melanoma patients. The effectiveness of these therapies decreases due to multidrug resistance (MDR).
Jacqueline Maphutha +4 more
wiley +1 more source
ChemMedChem, Volume 21, Issue 1, January 2026.Green chemistry‐based late‐stage functionalization (LSF) of the anti‐proprotein convertase subtilisin/kexin type 9 (PCSK9) early lead compound 5c led to optimized analogs with improved metabolic stability/PCSK9 IC50 ratio. Proprotein convertase subtilisin/kexin type 9 (PCSK9) is a key drug target for the treatment of different hypercholesterolemia ...
Lisa Giannessi +12 more
wiley +1 more source
Berberine reduces endoplasmic reticulum stress and improves insulin signal transduction in Hep G2 cells [PDF]
, 2010 Zeng-si Wang +3 more
openalex +1 more source
Biomass‐Derived Carbon Photocatalysts for Organic Pollutant Degradation: Strategies and Perspectives
Carbon Neutralization, Volume 5, Issue 1, January 2026.Recent advances in biomass‐derived carbon photocatalysts are highlighted, focusing on synthesis, surface engineering, and mechanisms such as ROS generation and band‐gap tuning. Heteroatom doping, heterojunctions, and hybrid architectures boost visible‐light activity, while scalability and stability challenges are addressed for practical environmental ...
Jagadis Gautam +6 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 1, January 2026.Schematic overview illustrating the anticancer mechanisms of selected natural products (resveratrol, quercetin, berberine) targeting EGFR and HER2 signaling pathways in tumor cells. These compounds inhibit receptor activation and downstream oncogenic cascades, including PI3K/Akt/mTOR, MAPK/ERK, and STAT3 pathways.
Iman Ramli +8 more
wiley +1 more source
Food Frontiers, Volume 7, Issue 1, January 2026.The Notch signaling pathway plays a dual role in cancer, acting as both a tumor promoter and suppressor depending on cellular context. This review highlights how natural products modulate Notch signaling to inhibit tumor initiation, progression, angiogenesis, and cancer stem cell maintenance.
Rabab Fatima +15 more
wiley +1 more source