Results 11 to 20 of about 28,920 (238)

Enhanced Intestinal Absorption and Pharmacokinetic Modulation of Berberine and Its Metabolites through the Inhibition of P-Glycoprotein and Intestinal Metabolism in Rats Using a Berberine Mixed Micelle Formulation

Pharmaceutics, 2020
We aimed to develop a berberine formulation to enhance the intestinal absorption and plasma concentrations of berberine through the inhibition of P-glycoprotein (P-gp)-mediated efflux and the intestinal metabolism of berberine in rats.
Mihwa Kwon, Dong Yu Lim, Chul Haeng Lee, Ji-Hyeon Jeon, Min-Koo Choi, Im-Sook Song   +5 more
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Berberine Prolongs Mouse Heart Allograft Survival by Activating T Cell Apoptosis via the Mitochondrial Pathway

Frontiers in Immunology, 2021
Berberine, which is a traditional Chinese medicine can inhibit tumorigenesis by inducing tumor cell apoptosis. However, the immunoregulatory of effects berberine on T cells remains poorly understood.
Yunhan Ma, Guoliang Yan, Junjun Guo, Fujun Li, Haiping Zheng, Chenxi Wang, Yingyu Chen, Yuhan Ye, Helong Dai, Helong Dai, Helong Dai, Zhongquan Qi, Guohong Zhuang   +12 more
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Redox regulation of the AMP-activated protein kinase. [PDF]

PLoS ONE, 2010
Redox state is a critical determinant of cell function, and any major imbalances can cause severe damage or death.The aim of this study is to determine if AMP-activated protein kinase (AMPK), a cellular energy sensor, is activated by oxidants generated ...
Yingying Han, Qilong Wang, Ping Song, Yi Zhu, Ming-Hui Zou   +4 more
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Pharmacokinetics and Excretion of Berberine and Its Nine Metabolites in Rats

Frontiers in Pharmacology, 2021
Berberine, a well-known alkaloid, has been proved to possess various pharmacological activities. Previous studies demonstrated that berberine could be extensively metabolized and the metabolites also contributed to its therapeutic effects.
Xinchi Feng, Kun Wang, Shijie Cao, Liqin Ding, Feng Qiu, Feng Qiu   +5 more
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Uptake of and Resistance to the Antibiotic Berberine by Individual Dormant, Germinating and Outgrowing Bacillus Spores as Monitored by Laser Tweezers Raman Spectroscopy. [PDF]

PLoS ONE, 2015
Berberine, an alkaloid originally extracted from the plant Coptis chinensis and other herb plants, has been used as a pharmacological substance for many years.
Shiwei Wang, Jing Yu, Milomir Suvira, Peter Setlow, Yong-qing Li   +4 more
doaj   +1 more source

Berberine inhibits breast carcinoma proliferation and metastasis under hypoxic microenvironment involving gut microbiota and endogenous metabolites

Pharmacological Research, 2023
A potential role of berberine, a benzyl isoquinoline alkaloid, in cancer therapy is apparent. Its underlying mechanisms of berberine against breast carcinoma under hypoxia have not been elucidated.
Yanfang Sun, QianQian Zhou, Fangming Chen, Xiaoyan Gao, Linjun Yang, Xiaoyan Jin, Michael Wink, Farukh S. Sharopov, Gautam Sethi   +8 more
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Molecular dynamics investigation of the interaction between Colletotrichum capsici cutinase and berberine suggested a mechanism for reduced enzyme activity.

PLoS ONE, 2021
Berberine is a promising botanical pesticide against fungal plant pathogens. However, whether berberine inhibits the invasion of fungal pathogen across plant surface remains unclear.
Ying Li, Jinqing Wei, Huizhen Yang, Jing Dai, Xizhen Ge   +4 more
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Berberine: a comprehensive Approach to combat human maladies

International Journal of Food Properties, 2023
Berberine is a metabolite of many medicinal plants. Chemically, berberine belongs to the isoquinoline alkaloids family. The roots of plants grown at lower elevations have a higher concentration of berberine as compared to plants grown at higher ...
Zarina Mushtaq, Muhammad Imran, Farhan Saeed, Ali Imran, Shinawar Waseem Ali, Muhammad Shahbaz, Suliman A. Alsagaby, Yolanda Guerrero Sánchez, Maryam Umar, Muzzamal Hussain, Waleed Al Abdulmonem, Entessar Al Jbawi, Mahwish, Ahmed H. El-Ghorab, Mohamed A. Abdelgawad   +14 more
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Berberine Reduces Lipid Accumulation by Promoting Fatty Acid Oxidation in Renal Tubular Epithelial Cells of the Diabetic Kidney

Frontiers in Pharmacology, 2022
Abnormal lipid metabolism in renal tubular epithelial cells contributes to renal lipid accumulation and disturbed mitochondrial bioenergetics which are important in diabetic kidney disease.
Qingfeng Rong, Baosheng Han, Yafeng Li, Yafeng Li, Haizhen Yin, Jing Li, Yanjuan Hou   +6 more
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A preliminary study on the synthetic lethal effect of berberine and olaparib on pancreatic cancer cells and its mechanism [PDF]

E3S Web of Conferences, 2021
Pancreatic cancer is a kind of malignant tumor with high mortality rate. Early operation and late chemoradiotherapy are the treatment criteria, but the prognosis is still poor.
Zhang Chengyong, Yang Tingting, Chen Xiaoting, Xu Jiexuan, Liang Danlu, Yi Huairu, Chen Size, Huang Lanlan, Liu Naihua, Lin Shaoqiang   +9 more
doaj   +1 more source