Results 81 to 90 of about 20,525 (171)
Digital Chinese Medicine, 2019 Objective: Liver cancer is the 4th leading cause of cancer death worldwide,and hepatocellular carcinoma (HCC) accounts for the largest proportion of these deaths.
Mu Jie +7 more
doaj +1 more source
Effects of type 2 diabetes mellitus on the pharmacokinetics of berberine in rats
Pharmaceutical Biology, 2017 Context: Berberine is an active alkaloid isolated from Rhizoma coptidis [Coptis chinensis Franch. (Ranunculaceae)] that is widely used for the treatment of diabetes, hyperlipidemia and hypertension.
Yuzhen Jia, Binger Xu, Jisen Xu
doaj +1 more source
Plant Biotechnology Journal, EarlyView.ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song +14 more
wiley +1 more source
Novel and emerging antimicrobial strategies in the management of oral infections
Periodontology 2000, EarlyView.Abstract Background Antibiotics marked a pivotal turning point in human civilization, enhancing social interactions and extending human life expectancy. In addition to their success in treating systemic infectious diseases, they have significantly improved periodontal treatment outcomes as an adjunct therapy.
Ozge Unlu, Nil Yakar, Alpdogan Kantarci
wiley +1 more source
Packaging Technology and Science, Volume 39, Issue 4, Page 367-382, April 2026.Development of biodegradable sodium alginate films incorporated with J. palmata root extracts showing enhanced antioxidant and functional properties for active food packaging applications. ABSTRACT Biodegradable packaging helps reduce environmental impact by decomposing naturally and preventing plastic accumulation in ecosystems.
Carlos Augusto Badillo Almeira +4 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2685-2697, April 2026.ABSTRACT Cannabinoids, such as tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA), are bioactive and medicinally relevant compounds found in the cannabis plant (Cannabis sativa L.). These three compounds are synthesised from a single precursor, cannabigerolic acid (CBGA), through regioselective reactions ...
Cloé Villard +5 more
wiley +1 more source
Plant Biotechnology Journal, Volume 24, Issue 4, Page 2642-2656, April 2026.ABSTRACT Nicotine is the most abundant alkaloid produced by Nicotiana species against insect herbivores. Although it has been known for decades that auxin can strongly inhibit nicotine biosynthesis, the underlying mechanisms have remained unclear.
Miyun Yang +3 more
wiley +1 more source
The FASEB Journal, Volume 40, Issue 6, 31 March 2026.Description: This review synthesizes groundbreaking advances in the gut‐liver axis for MASLD management. It details mechanistic pathways from transkingdom dysbiosis to liver pathology, integrating AI‐driven diagnostics and host genetics (PNPLA3). The framework transitions from broad microbial restoration to precision medicine, showcasing targeted ...
Shaoliang Zhu +8 more
wiley +1 more source
Targeting Expanded CUG and CTG Repeats as a Therapeutic Approach for Myotonic Dystrophy Type 1 (DM1)
ChemMedChem, Volume 21, Issue 5, 13 March 2026.DM1 is an RNA gain‐of‐function disease caused by CTG repeat expansion, producing toxic r(CUG)exp RNA that sequesters MBNL1 and impairs splicing. This review covers the field of CUG and CTG ligands identified or rationally designed as DM1 drug candidates, highlighting their molecular design, RNA‐ or DNA‐binding modes, in vitro affinities and ...
Camille Richagneux, Anton Granzhan
wiley +1 more source