Results 91 to 100 of about 81,348 (224)

Blocking Msr1 by berberine alkaloids inhibits caspase-11-dependent coagulation in bacterial sepsis. [PDF]

Signal Transduct Target Ther, 2021
Yuan C, Wu M, Xiao Q, Zhao W, Li H, Zhong Y, Zhao M, Li C, Li Y, Yang X.   +9 more
europepmc   +1 more source

Evaluation of HSYA and Carthamin Accumulation in Safflower (Carthamus tinctorius L.) Induced by Chemical Mutagens (EMS and SA) in M1 and M2 Generations

Plant Breeding, EarlyView.
ABSTRACT Historically cultivated for medicinal and dyeing purposes, safflower (Carthamus tinctorius L.) saw a shift towards widespread oilseed production after the 1920s due to the growing importance of oils. However, there is a renewed interest in its medicinal and dyeing properties today.
Tansu Uskutoglu, Nurullah Kartaloglu, Belgin Cosge Senkal   +2 more
wiley   +1 more source

Antioxidant and cytotoxic activities of Thai medicinal plants named Khaminkhruea: Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria [PDF]

Songklanakarin Journal of Science and Technology (SJST), 2005
The stems of Arcangelisia flava, Coscinium blumeanum and Fibraurea tinctoria, collectively known in southern Thailand as Khaminkhruea, were sequentially extracted with petroleum ether, chloroform, methanol, and boiling water to afford 12 crude extracts ...
Niwat Keawpradub, Sukanya Dej-adisai, Supreeya Yuenyongsawad   +2 more
doaj  

Cytotoxic and Proapoptotic Activity of Sanguinarine, Berberine, and Extracts of Chelidonium majus L. and Berberis thunbergii DC. toward Hematopoietic Cancer Cell Lines

Toxins, 2019
Isoquinoline alkaloids belong to the toxic secondary metabolites occurring in plants of many families. The high biological activity makes these compounds promising agents for use in medicine, particularly as anticancer drugs.
Anna Och, Daniel Zalewski, Łukasz Komsta, Przemysław Kołodziej, Janusz Kocki, Anna Bogucka-Kocka   +5 more
doaj   +1 more source

SGLT2i in heart failure: Cardiorenal mechanisms, clinical evidence and translational perspectives

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
SGLT2 inhibitors improve heart failure outcomes through integrated cardiorenal mechanisms. In the kidney, they reduce glucose and sodium reabsorption, promoting natriuresis, osmotic diuresis and renal protection. In the heart, they enhance myocardial energetics, reduce inflammation, oxidative stress, fibrosis and adverse remodelling, resulting in fewer
Jelica Grujic‐Milanovic, Jovana Rajkovic, Radmila Novakovic, Javad Sharifi‐Rad, Daniela Calina   +4 more
wiley   +1 more source

Mitigating Cancer Therapy–Related Cognitive Impairment by Targeted Activation of Undruggable Phosphatase

Advanced Science, Volume 13, Issue 52, 18 September 2026.
An RVG‑engineered exosomal saRNA delivery system (RVG‑EVs‑saPtpro) effectively targets and activates hippocampal PTPRO, functioning as a “molecular brake” to alleviate cancer therapy‑related cognitive impairment (CTRCI) by enhancing neuronal survival, neurogenesis, and synaptic plasticity.
Zhimeng Yao, Yuhua Meng, Huanyi Li, Yinhui Jiang, Xiaona Lin, Mengyuan Hu, Qing Liu, Xiaofu Qiu, Hongzheng Ren, Yunlong Pan, Bin Pan, Zexiong Guo, Shuyao Zhang, Dianzheng Zhang, Li Yang, Shegan Gao, Weijing Deng, Jianfan Chen, Hao Zhang   +18 more
wiley   +1 more source

Engineering CAR‐Macrophages With Advanced Delivery Systems for Tissue Repair

Advanced Science, Volume 13, Issue 51, 14 September 2026.
This review highlights how engineered macrophages equipped with chimeric antigen receptors (CAR) guide tissue repair by recognizing disease‐related targets, clearing harmful cells, and reshaping local immune environments. It summarizes macrophage biology, CAR design, delivery platforms, and functionalization strategies, and discusses emerging ...
Yixin Zhang, Jintian Yu, Liang Yuan, Ziliang Fu, Yiming Yao, Lingna Chen, Shixiong Chen, Aikemu Ainiwaer, Xiaolin Cui   +8 more
wiley   +1 more source

Berberine-INF55 (5-nitro-2-phenylindole) hybrid antimicrobials: effects of varying the relative orientation of the berberine and INF55 components

, 2010
Hybrid antimicrobials containing an antibacterial linked to a multidrug resistance (MDR) pump inhibitor make up a promising new class of agents for countering efflux-mediated bacterial drug resistance.
Danuta Tomkiewicz (20241213), Gabriele Casadei (2362381), Jonah Larkins-Ford (53012), Frederik M Ausubel (20215065), Kim Lewis (20864), John Bremner (19588816), Terence I Moy (20241216), James Garner (20117208), Michael Kelso (19588105)   +8 more
core   +1 more source

Significant differences in alkaloid content of Coptis chinensis (Huanglian), from its related American species

Chinese Medicine, 2009
Background The growing popularity of Chinese herbal medicine in the United States has prompted large-scale import of raw herbs from Asia. Many of the Asian herbs have phylogenetically related North American species.
Skeels Matthew, Kamath Shreya, Pai Aswini   +2 more
doaj   +1 more source

Natural Compounds Targeting Oncogenic Signaling Networks in Glioblastoma: Molecular Mechanisms, Translational Advances, and Clinical Perspectives

Brain and Behavior, Volume 16, Issue 9, September 2026.
Glioblastoma (GBM) is a highly aggressive brain tumor with a poor prognosis, driven by abnormal signaling pathways that promote growth and resistance to treatment. Conventional therapies are inadequate, highlighting the need for novel multitargeted approaches.
Mehrukh Zehravi, Md Abul Hassan, Md. Al Amin, Sherouk Hussein Sweilam, Jeetendra Kumar Gupta, Ramenani Hari Babu, Pericharla Venkata Narasimha Raju, Krishna Vamsi Kandimalla, Phanindra Erukulla, Patibandla Jahnavi, Rajeshwar Vodeti, Abdul Ajeed Mohathasim Billah, Safia Obaidur Rab, Sharuk L. Khan   +13 more
wiley   +1 more source