Results 71 to 80 of about 81,348 (224)

Bioactive Natural Products in Cardiovascular Disease: Focus on Thrombotic Events

Phytotherapy Research, EarlyView.
An overview of the role of natural products (NP) in cardiovascular disease prevention, highlighting key mechanisms of action: including antiplatelet, antithrombotic, anti‐inflammatory, and antioxidant effects. Additionally, it illustrates the integration of diet–drug interactions, nutritional epigenetics, and the role of artificial intelligence in ...
Maria Nektaria Magkoulia, Despoina Pantazi   +1 more
wiley   +1 more source

'Dopamine-first' mechanism enables the rational engineering of the norcoclaurine synthase aldehyde activity profile. [PDF]

, 2015
Norcoclaurine synthase (NCS) (EC 4.2.1.78) catalyzes the Pictet-Spengler condensation of dopamine and an aldehyde, forming a substituted (S)-tetrahydroisoquinoline, a pharmaceutically important moiety.
Nicholas H. Keep, Markus C. Gershater, Helen C. Hailes, Ward, J.M., Pesnot, T, Eleanor D. Lamming, Pesnot, T., Thomas Pesnot, Hailes, HC, Gershater, M.C., Ward, JM, Lamming, E.D., Keep, Nicholas H., Altin Sula, Keep, NH, Hailes, H.C., Lichman, B.R., John M. Ward, Sula, Altin, Benjamin R. Lichman, Lichman, BR, Gershater, MC, Sula, A, Lamming, ED   +23 more
core   +1 more source

Marine pyridoacridine, pyridoacridone and pyrroloacridine alkaloids

, 2023
The families of pyridoacridine, pyridoacridone, and pyrroloacridine alkaloids are fascinating classes of natural products that have attracted the attention of chemists for over 80 years.
Cadelis, Melissa M, Copp, Brent R
core   +1 more source

Berberine suppresses migration of MCF-7 breast cancer cells through down-regulation of chemokine receptors [PDF]

Iranian Journal of Basic Medical Sciences, 2016
Objective(s): Berberine is one of the main alkaloids and it has been proven to have different pharmacological effects including inhibition of cell cycle and progression of apoptosis in various cancerous cells; however, its effects on cancer metastasis ...
Naghmeh Ahmadiankia, Hamid Kalalian Moghaddam, Mohammad Amir Mishan, Ahmad Reza Bahrami, Hojjat Naderi-Meshkin, Hamid Reza Bidkhori, Maryam Moghaddam, Seyed Jamal Aldin Mirfeyzi   +7 more
doaj  

Antifungal alkaloids from Mahonia fortunei against pathogens of postharvest fruit

Natural Products and Bioprospecting, 2023
Postharvest pathogens can affect a wide range of fresh fruit and vegetables, including grapes, resulting in significant profit loss. Isoquinoline alkaloids of Mahonia fortunei, a Chinese herbal medicine, have been used to treat infectious microbes, which
Xiao-Na Wang, Zhao-Jie Wang, Yun Zhao, Huan Wang, Mei-Ling Xiang, Yang-Yang Liu, Li-Xing Zhao, Xiao-Dong Luo   +7 more
doaj   +1 more source

Multitarget Regulatory Mechanisms and Research Advances of Plant‐Derived Bioactive Ingredients in Hypertension Prevention and Management

Phytotherapy Research, EarlyView.
Schematic overview of the multi‐target and multi‐pathway mechanisms of PDBI in the prevention and management of hypertension. ABSTRACT Hypertension remains a major global risk factor for cardiovascular diseases, yet current treatments face challenges such as suboptimal blood pressure control and inadequate organ protection.
Qiqi Deng, Yonglin Zhang, Jing Pan, Jing Luo, Hualin Sun, Chaonian Li, Li Li   +6 more
wiley   +1 more source

The relationship of physico-chemical properties and structure to the differential antiplasmodial activity of the cinchona alkaloids. [PDF]

, 2003
BACKGROUND: The 8-amino and 9-hydroxy substituents of antimalarial cinchona alkaloids have the erythro orientation while their inactive 9-epimers are threo.
Meyer David J, Adagu Ipemida S, Adagu, Ipemida S, Warhurst David C, Sylvia Y Lee, Meyer, David J, David C Warhurst, Craig John C, David J Meyer, Warhurst, David C, Lee, Sylvia Y, Ipemida S Adagu, Craig, John C, John C Craig, Lee Sylvia Y   +14 more
core   +1 more source

Dose-dependent effects of melatonin on berberine production, antioxidant activity, and metabolite profiles in Berberis vulgaris L. suspension cultures

Scientific Reports
Melatonin is a regulatory molecule that increases secondary metabolite biosynthesis in plants. Berberis vulgaris L. is a well-known medicinal plant, valued for its alkaloids and phenolic compounds.
Seyedeh Hanieh Zeidi, Mohsen Sharifi, Elaheh Samari, Faezeh Ghanati, Vahid Niknam, Nastaran Zhaleh   +5 more
doaj   +1 more source

Binding Parameters of Alkaloids Berberine and Sanguinarine with DNA

Ukrainian Journal of Physics, 2012
10 pages, 9 ...
Gumenyuk, V.G., Bashmakova, N.V., Kutovyy, S.Yu., Yashchuk, V.M., Zaika, L.A.   +4 more
openaire   +3 more sources

Transcriptional profile of theShigella flexneriresponse to an alkaloid: berberine [PDF]

FEMS Microbiology Letters, 2010
Berberine, a natural isoquinoline alkaloid found in many medicinal herbs, has been shown to be active against a variety of microbial infections. To examine the potential effects of berberine on Shigella flexneri, a whole-genome DNA microarray was constructed and a transcriptome analysis of the cellular responses of S. flexneri when exposed to berberine
Hua, Fu, Li-Guo, Liu, Jun-Ping, Peng, Wen-Chuan, Leng, Jian, Yang, Qi, Jin   +5 more
openaire   +2 more sources