Palmatine Attenuates LPS-Induced EMT in MAC-T Cells and Mammary Fibrosis in Mice, with Suppression of NF-κB/TGF-β1/Smad Signaling In Vivo [PDF]
AnimalsBovine mastitis is a common inflammatory disease that can progress to mammary fibrosis, thereby impairing udder health, milk yield, and milk quality.
Dongxue Shi +7 more
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Palmatine potentiates cefquinome efficacy against multidrug-resistant Escherichia coli via sulfur/taurine metabolism and oxidative stress modulation [PDF]
Frontiers in MicrobiologyPalmatine, a natural isoquinoline alkaloid derived from Fibraureae Caulis, is widely used for its heat-clearing, detoxifying, antibacterial, and anti-inflammatory properties.
Yining Zhang +15 more
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Palmatine ameliorates MASLD in type 2 diabetes by modulating hepatic apoptosis and inflammation [PDF]
Scientific ReportsType 2 diabetes mellitus (T2DM) is a major risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), and their convergence presents a significant therapeutic challenge. Palmatine, an isoquinoline alkaloid with lipid-regulating and
Huasen Yang +8 more
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Small Molecule Palmatine Targeting Musashi-2 in Colorectal Cancer [PDF]
Frontiers in Pharmacology, 2022 Musashi-2 (MSI2) is an evolutionally conserved RNA-binding protein and recently considered as an attractive therapeutic target in a wide spectrum of malignancies.
Xue Zhang +7 more
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Palmatine treats urticaria by reducing inflammation and increasing autophagy
Frontiers in Immunology, 2023 IntroductionChronic spontaneous urticaria (CSU) is mainly manifested as wheals and erythema on the skin accompanied by itching, which will cause emotional anxiety and seriously affect the quality of life in patients.
Tian Xiao +3 more
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From traditional remedy to modern therapy: a comprehensive review of palmatine’s multi-target mechanisms and ethnopharmacological potential [PDF]
Frontiers in PharmacologyBackgroundAs a core active metabolite of traditional Chinese medicines including Coptis chinensis Franch. and Phellodendron amurense Rupr., palmatine has been employed in Asian traditional medicine for centuries, primarily for treating jaundice, liver ...
Zhoujing Shi +5 more
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Analgesic and Anti-Arthritic Potential of Methanolic Extract and Palmatine Obtained from Annona squamosa Leaves [PDF]
PharmaceuticalsBackground/Objectives: Annona squamosa is used in folk medicine to treat pain and arthritis. Palmatine is an alkaloid isolated from several plants, including A. squamosa leaves.
Caren Naomi Aguero Ito +10 more
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Pharmacokinetics and Tissue Distribution of Palmatine after Single Intramuscular Injection in Partridge Shank Chickens [PDF]
Veterinary Medicine and SciencePalmatine is an isoquinoline alkaloid isolated from many medicinal plants with diverse pharmacological activities, with potential for the treatment of chronic metabolic disorders and infectious diseases.
Chaoxi Chen +5 more
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Cheminformatics-driven discovery of natural isoquinoline alkaloid inhibitors of Beta-secretase I for Alzheimer's management. [PDF]
PLoS ONEAlzheimer's disease (AD) is characterized by the gradual deterioration of cognitive functions, speech impairment, and memory loss. It can potentially be treated by targeting the beta-site amyloid precursor protein cleavage enzyme 1 (BACE1), which plays a
Iqra Ahmad +11 more
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Berberine and Palmatine Distribution Across Plant Organs in Berberis darwinii: Basis for Selecting Superior-Producing Accessions [PDF]
MoleculesBerberis darwinii, known for its bioactive alkaloids like berberine and palmatine, has gained attention for its medicinal properties. However, comprehensive studies on the specific bioactive molecules of Michay are lacking, as previous research has ...
Manuel Chacón-Fuentes +4 more
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