Palmatine Attenuates LPS-Induced EMT in MAC-T Cells and Mammary Fibrosis in Mice, with Suppression of NF-κB/TGF-β1/Smad Signaling In Vivo. [PDF]
Animals (Basel)Bovine mastitis is a common inflammatory disease that can progress to mammary fibrosis, thereby impairing udder health, milk yield, and milk quality.
Shi D +7 more
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Palmatine potentiates cefquinome efficacy against multidrug-resistant <i>Escherichia coli</i> via sulfur/taurine metabolism and oxidative stress modulation. [PDF]
Front MicrobiolPalmatine, a natural isoquinoline alkaloid derived from Fibraureae Caulis, is widely used for its heat-clearing, detoxifying, antibacterial, and anti-inflammatory properties.
Zhang Y +12 more
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Palmatine ameliorates MASLD in type 2 diabetes by modulating hepatic apoptosis and inflammation. [PDF]
Sci RepType 2 diabetes mellitus (T2DM) is a major risk factor for metabolic dysfunction-associated steatotic liver disease (MASLD), and their convergence presents a significant therapeutic challenge. Palmatine, an isoquinoline alkaloid with lipid-regulating and
Yang H +8 more
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From traditional remedy to modern therapy: a comprehensive review of palmatine's multi-target mechanisms and ethnopharmacological potential. [PDF]
Front PharmacolBackgroundAs a core active metabolite of traditional Chinese medicines including Coptis chinensis Franch. and Phellodendron amurense Rupr., palmatine has been employed in Asian traditional medicine for centuries, primarily for treating jaundice, liver ...
Shi Z, Han L, Yang H, Lu G, Shi Z, Ma B.
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Pharmacokinetics and Tissue Distribution of Palmatine after Single Intramuscular Injection in Partridge Shank Chickens. [PDF]
Vet Med SciPalmatine is an isoquinoline alkaloid isolated from many medicinal plants with diverse pharmacological activities, with potential for the treatment of chronic metabolic disorders and infectious diseases.
Chen C +5 more
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Cheminformatics-driven discovery of natural isoquinoline alkaloid inhibitors of Beta-secretase I for Alzheimer's management. [PDF]
PLoS OneAlzheimer's disease (AD) is characterized by the gradual deterioration of cognitive functions, speech impairment, and memory loss. It can potentially be treated by targeting the beta-site amyloid precursor protein cleavage enzyme 1 (BACE1), which plays a
Ahmad I +11 more
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Notulae Scientia Biologicae, 2023 The study was performed to investigate the possible neuroprotective role of palmatine, a protoberberine alkaloid against aluminum-induced aberration in neurotransmitter levels, excitotoxicity, neuronal inflammation, damage, and degeneration.
Ratna BABURAJ +2 more
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Scientific African, 2021 Chemoresistance develops in triple negative breast cancer cells during prolonged therapy with chemotherapeutic drugs, diminishing the benefits of these drugs in breast cancer patients. Palmatine, a natural alkaloid extracted from several medicinal plants
Selase Ativui +4 more
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Palmatine Inhibits the Pathogenicity of Aeromonas hydrophila by Reducing Aerolysin Expression
Foods, 2022 Aeromonas hydrophila, an opportunistic aquatic pathogen widely spread in aquatic environments, is responsible for a number of infectious diseases in freshwater aquaculture. In addition, A.
Jing Dong +7 more
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BMC Veterinary Research, 2023 Canine mammary gland tumors (CMTs) are the most common and lethal cancers in female dogs. Dysregulated phosphoinositide 3-kinases (PI3K)/AKT pathway reportedly was involved in the growth and metastasis of CMTs.
Min-Jae Yoo +4 more
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