Results 31 to 40 of about 2,409 (171)

Evaluation of palmatine as an immunostimulant in diet for genetically improved farmed tilapia (GIFT, Oreochromis niloticus)

Aquaculture Reports
Palmatine as a medicinal herbs extract has strong bacteriostatic ability and is a promising source of antibacterial additive. The objective of this study was to assess the feasibility of palmatine as an antibiotic alternative in diet for genetically ...
Xinlangji Fu, Ying Li, Lu Zhang, Haifeng Mi, Junming Deng   +4 more
doaj   +1 more source

An Analysis in Identifying the Mechanism of Action of the Alkaloids Found in on the Treatment and Prevention of SARS-CoV-2

Natural Product Communications, 2023
Introduction Berberis vulgaris extract is a well-known herbal remedy for treating numerous conditions including coronavirus disease 2019 (COVID-19). The HAB4a method of preparing the extract is a common method used in clinical practice and a further aim ...
Samantha Gildenhuys, Paul Anton Steenkamp, Lucas Sekele, Salerwe Mosebi, Chad Clifton James   +4 more
doaj   +1 more source

Natural Aromatic Compounds as Scaffolds to Develop Selective G-Quadruplex Ligands: From Previously Reported Berberine Derivatives to New Palmatine Analogues

Molecules, 2018
In this paper, the selective interactions of synthetic derivatives of two natural compounds, berberine and palmatine, with DNA G-quadruplex structures were reported.
Marco Franceschin, Lorenzo Cianni, Massimo Pitorri, Emanuela Micheli, Stefano Cacchione, Claudio Frezza, Mauro Serafini, Ming-Hao Hu, Huafi Su, Zhishu Huang, Lianquan Gu, Armandodoriano Bianco   +11 more
doaj   +1 more source

Synthesis and Cytotoxicity Evaluation of 13-<em>n</em>-Alkyl Berberine and Palmatine Analogues as Anticancer Agents

Molecules, 2012
By introducing long carbon-chain alkyl groups at the C-13 position of berberine and palmatine, 13-<em>n</em>-hexyl/13-<em>n</em>-octyl berberine and palmatine chloride analogues <strong>4a</strong>–<strong>d </
Lei Zhang, Jingjing Li, Fei Ma, Shining Yao, Naisan Li, Jing Wang, Yongbin Wang, Xiuzhen Wang, Qizheng Yao   +8 more
doaj   +1 more source

Investigating Palmatine’s inhibitory mechanism on type 2 diabetes via molecular docking

Vietnam Journal of Science, Technology and Engineering
Type 2 diabetes mellitus (T2DM) is the most common form, accounting for more than 90% of all individuals with diabetes worldwide. Currently, T2DM is on the rise and is increasingly affecting younger individuals, becoming a serious public health issue ...
Do Thi Hang, Tran Hoang Mai, Nguyen Thi Phuong, Bui Thanh Tung   +2 more
doaj   +1 more source

Therapeutic Potential of Berberis vulgaris in Modulating Metabolic Syndrome Biomarkers: Mechanistic Insights and Functional Food Implications

Food Frontiers, Volume 7, Issue 4, July 2026.
ABSTRACT Barberry (Berberis vulgaris) has emerged as a promising functional food candidate for the management of metabolic syndrome due to its diverse bioactive constituents, particularly berberine. This review synthesizes current experimental and clinical evidence regarding its effects on glycemic control, lipid metabolism, blood pressure regulation ...
Fakhar Shahid, Ifrah Jabeen, Muhammad Inam‐ur‐Raheem, Amin Mousavi Khaneghah, Muhammad Abid, Rana Muhammad Aadil   +5 more
wiley   +1 more source

Palmatine attenuates isoproterenol-induced pathological hypertrophy via selectively inhibiting HDAC2 in rats

International Journal of Immunopathology and Pharmacology, 2017
This study aimed to exploit the potential therapeutic value of palmatine in treatment of cardiac hypertrophy and the underlying molecular mechanism. Rat hypertrophy model was established by intraperitoneal isoproterenol (ISO) injection.
Yonggang Yuan, Wanzhong Peng, Yongxing Liu, Zesheng Xu   +3 more
doaj   +1 more source

Natural Products as Modulators of ABC Transporters in Breast Cancer

Phytotherapy Research, Volume 40, Issue 7, Page 4611-4637, July 2026.
ABSTRACT Breast cancer remains a significant global health challenge, with high incidence and mortality rates despite advancements in early detection and treatment. Multidrug resistance (MDR), particularly in aggressive subtypes like triple‐negative breast cancer (TNBC), continues to hinder effective therapy.
Yoganishalini Sagadevan, Reyhaneh Farghadani, Ammu K. Radhakrishnan   +2 more
wiley   +1 more source

Structural Elucidation and Engineering of the (S)‐scoulerine 2‐O‐Methyltransferase Enabling Regioselective Epiberberine Biosynthesis in Coptis chinensis

Plant Biotechnology Journal, Volume 24, Issue 7, Page 4528-4545, July 2026.
ABSTRACT Protoberberine alkaloids are a characteristic group of natural products in Coptis plants known for their notable pharmacological activities. However, the structural similarity and the substrate promiscuity of their biosynthetic enzymes have left the precise synthetic pathways remain unclarified, posing challenges to regulate product formation.
Jun Song, Di Liu, Shi Chen, Yufeng Tan, Siyu Wang, Shihan Li, Yutong Qin, Guofeng Li, Xufang Tian, Lan Yang, Chong Yuan, Junbo Gou, Wei Huang, Shilin Chen, Yifei Liu   +14 more
wiley   +1 more source

Photocatalytic Duplex-Based DNAzymes Switched by an Abasic Site

Chemistry, 2023
DNAzymes have attracted increasing interest in developments of gene tools, therapies, and biosensors. Among them, G-quadruplexes are widely used as the key structure elements of DNAzymes to activate the catalytic competency of specific cofactors, such as
Longlong Gao, Rui Tian, Yong Shao
doaj   +1 more source