Results 21 to 30 of about 2,409 (171)

Effects of palmatine on BDNF/TrkB-mediated trigeminal neuralgia [PDF]

Scientific Reports, 2020
AbstractTrigeminal neuralgia (TN), a sudden, needle-like pain in the distribution area of the trigeminal nerve, can seriously affect the physical and mental health of patients. In chronic pain conditions including TN, increased levels of brain-derived neurotrophic factor (BDNF) may enhance pain transmission.
Lijuan Liu, Lingkun He, Cancan Yin, Ruoyu Huang, Wenhao Shen, Huixiang Ge, Mengyun Sun, Shujuan Li, Yun Gao, Wei Xiong   +9 more
openaire   +2 more sources

Compound Analysis and Mechanistic Exploration of Shen-Yan-Fang-Shuai Formula in Diabetic Kidney Disease: An UHPLC-MS/MS and Bioinformatics Study. [PDF]

J Diabetes Res
Background Diabetic kidney disease (DKD) is significantly impacting both quality of life and survival rates. The Shen‐Yan‐Fang‐Shuai (SYFS) formula is a traditional Chinese medicine (TCM) compound widely used in the clinical treatment of DKD with proven efficacy, though its potential mechanism of action remains unclear. This study attempts to elucidate
Kang Y, Jin Q, Zhou M, Zheng H, Li D, Wang X, Zhou J, Lv J, Wang Y.   +8 more
europepmc   +2 more sources

Palmatine Protects PC12 Cells and Mice from Aβ25-35-Induced Oxidative Stress and Neuroinflammation via the Nrf2/HO-1 Pathway

Molecules, 2023
Alzheimer’s disease is a common degenerative disease which has a great impact on people’s daily lives, but there is still a certain market gap in the drug research about it. Palmatine, one of the main components of Huangteng, the rattan stem of Fibraurea
Yu Wang, Hongyan Pei, Weijia Chen, Rui Du, Jianming Li, Zhongmei He   +5 more
doaj   +1 more source

Berberine and palmatine inhibit the growth of human rhabdomyosarcoma cells [PDF]

Bioscience, Biotechnology, and Biochemistry, 2020
ABSTRACT A natural isoquinoline alkaloid, berberine, has been known to exhibit anti-tumor activity in various cancer cells via inducing cell cycle arrest. However, it has not been investigated whether berberine and its analogs inhibit the growth of rhabdomyosarcoma (RMS), which is the most frequent soft tissue tumor in children.
Sayaka, Shinji, Shunichi, Nakamura, Yuma, Nihashi, Koji, Umezawa, Tomohide, Takaya   +4 more
openaire   +2 more sources

Antioxidant and anti-advanced glycation end products formation properties of palmatine [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: Oxidative stress and formation of advanced glycation end products (AGEs), due to glycation of proteins, lipids and nucleic acids are characteristic in diabetic patients.
Sharma Mridula, Wardah Siddiqui Masroor, Mellinnda Xavier, Tan Wen Hui, Hor Kuan Chan, Kavita Chirara, Okechukwu Patrick Nwabueze   +6 more
doaj  

Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze

Advances in Pharmacological Sciences, 2012
The present study was designed to evaluate the effect of palmatine on memory of Swiss young male albino mice. Palmatine (0.1, 0.5, 1 mg/kg, i.p.) and physostigmine (0.1 mg/kg, i.p.) per se were administered for 10 successive days to separate groups of ...
Dinesh Dhingra, Varun Kumar
doaj   +1 more source

Inductive Effect of Palmatine on Apoptosis in RAW 264.7 Cells [PDF]

Evidence-Based Complementary and Alternative Medicine, 2016
Osteoporosis is a serious public health problem characterized by low bone density and deterioration of the bone microarchitecture. Current treatment options target either osteoclast resorption or osteoblast formation. It has been reported that berberine, a close structural analog of palmatine, inhibited bone loss in an osteoporosis model. In this study,
Ishikawa, Shintaro, Tamaki, Misako, Ogawa, Yui, Kaneki, Kiyomi, Zhang, Meng, Sunagawa, Masataka, Hisamitsu, Tadashi   +6 more
openaire   +2 more sources

Comparative Studies of Palmatine with Metformin and Glimepiride on the Modulation of Insulin Dependent Signaling Pathway In Vitro, In Vivo & Ex Vivo

Pharmaceuticals, 2022
(1) Insulin resistance, a symptom of type 2 diabetes mellitus (T2DM), is caused by the inactivation of the insulin signaling pathway, which includes IRS-PI3K-IRS-1-PKC-AKT2 and GLUT4.
Okechukwu Patrick Nwabueze, Mridula Sharma, Abbirami Balachandran, Anand Gaurav, Anis Najwa Abdul Rani, Jeleń Małgorzata, Morak-Młodawska Beata, Charlie A. Lavilla, Merell P. Billacura   +8 more
doaj   +1 more source

Mosquitocidal Activity of the Methanolic Extract of Annickia chlorantha and Its Isolated Compounds against Culex pipiens, and Their Impact on the Non-Target Organism Zebrafish, Danio rerio

Insects, 2022
In this study, the crude extract and its isolated compounds from the stem bark of Annickia chlorantha were tested for their larvicidal, developmental, and repellent activity against the mosquito vector, Culex pipiens, besides their toxicity to the non ...
Tharwat A. Selim, Ibrahim E. Abd-El Rahman, Hesham A. Mahran, Hamza A. M. Adam, Vincent Imieje, Ahmed A. Zaki, Mansour A. E. Bashar, Hossam Hwihy, Abdelaaty Hamed, Ahmed A. Elhenawy, Eman S. Abou-Amra, Samia E. El-Didamony, Ahmed I. Hasaballah   +12 more
doaj   +1 more source

Effective Extraction of Palmatine and Berberine from Coptis chinensis by Deep Eutectic Solvents-Based Ultrasound-Assisted Extraction

Journal of Analytical Methods in Chemistry, 2021
The effective components of Coptis chinensis were extracted by ultrasound-assisted technology, and the contents of palmatine and berberine were used as indexes by using Coptis chinensis as raw material and eutectic solvent as extractant. In addition, the
Lijing Li, Dong Zhang, Yuejie Wang, Fangxin Liu, Yang Xu, Huiwei Bao   +5 more
doaj   +1 more source