Results 11 to 20 of about 2,409 (171)
Label-Free and Immobilization-Free Protein-Binding Assays by Ultraviolet Transient Absorption Microscopy. [PDF]
Adv Sci (Weinh)A femtosecond UV pump–probe microscope resolves binding‐induced changes in protein excited‐state dynamics and converts these intrinsic contrasts into an equilibrium affinity readout. By probing tryptophan responses directly in solution, the approach enables quantitative determination of dissociation constants without labeling or immobilization ...
Shen J +5 more
europepmc +2 more sources
Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3‐dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific role in driving lung cancer–associated ...
Han L +12 more
europepmc +2 more sources
Notulae Scientia Biologicae, 2023 The study was performed to investigate the possible neuroprotective role of palmatine, a protoberberine alkaloid against aluminum-induced aberration in neurotransmitter levels, excitotoxicity, neuronal inflammation, damage, and degeneration.
Ratna BABURAJ +2 more
doaj +1 more source
Scientific African, 2021 Chemoresistance develops in triple negative breast cancer cells during prolonged therapy with chemotherapeutic drugs, diminishing the benefits of these drugs in breast cancer patients. Palmatine, a natural alkaloid extracted from several medicinal plants
Selase Ativui +4 more
doaj +1 more source
Palmatine Inhibits the Pathogenicity of Aeromonas hydrophila by Reducing Aerolysin Expression
Foods, 2022 Aeromonas hydrophila, an opportunistic aquatic pathogen widely spread in aquatic environments, is responsible for a number of infectious diseases in freshwater aquaculture. In addition, A.
Jing Dong +7 more
doaj +1 more source
BMC Veterinary Research, 2023 Canine mammary gland tumors (CMTs) are the most common and lethal cancers in female dogs. Dysregulated phosphoinositide 3-kinases (PI3K)/AKT pathway reportedly was involved in the growth and metastasis of CMTs.
Min-Jae Yoo +4 more
doaj +1 more source
Ueber Palmatin und Columbamin [PDF]
Archiv der Pharmazie, 1918 n ...
Feist, K., Sandstede, Gerhard
openaire +2 more sources
Palmatine Attenuates Metastatic Lung Colonization of Triple Negative Breast Cancer Cells
Frontiers in Pharmacology, 2022 Background: Metastatic breast cancer to the lungs is a serious, life-threatening complication that is difficult to cure. Circulating tumor cells play a key role in the metastatic spread of breast cancer to the lungs via the lymphatic or circulatory ...
Selase Ativui +3 more
doaj +1 more source
Pharmaceutical Biology, 2020 Context Palmatine, a biologically active isoquinoline alkaloid, possesses multiple pharmaceutical activities against mucosal infection and inflammation.
Wang Hui +9 more
doaj +1 more source
Cells, 2020 Palmatine (PALM) and berberine (BERB) are widely identified isoquinoline alkaloids among the representatives of the Berberidaceae botanical family. The antiseizure activity of BERB was shown previously in experimental epilepsy models.
Kinga Gawel +8 more
doaj +1 more source