Results 11 to 20 of about 2,464 (131)

Label-Free and Immobilization-Free Protein-Binding Assays by Ultraviolet Transient Absorption Microscopy. [PDF]

Adv Sci (Weinh)
A femtosecond UV pump–probe microscope resolves binding‐induced changes in protein excited‐state dynamics and converts these intrinsic contrasts into an equilibrium affinity readout. By probing tryptophan responses directly in solution, the approach enables quantitative determination of dissociation constants without labeling or immobilization ...
Shen J, Wang Q, Wu F, Gao Y, Lan L, Wang P.   +5 more
europepmc   +2 more sources

Cancer IDO1-Mediated Tryptophan-Kynurenine Metabolic Reprogramming to Drive Skeletal Muscle Atrophy and Cachexia Acceleration. [PDF]

J Cachexia Sarcopenia Muscle
ABSTRACT Background Cancer cachexia is a debilitating syndrome characterized by severe skeletal muscle wasting, which significantly impairs patient quality of life and survival. Indoleamine 2,3‐dioxygenase 1 (IDO1), a key enzyme in tryptophan (Trp) metabolism, is often upregulated in cancers, but its specific role in driving lung cancer–associated ...
Han L, Jing L, Zhu X, Li C, Bai L, Fang Y, Zhou Y, Bai D, Lu J, Han Y, Guo C, Zhou S, Yang Q.   +12 more
europepmc   +2 more sources

Palmatine Attenuates Metastatic Lung Colonization of Triple Negative Breast Cancer Cells

Frontiers in Pharmacology, 2022
Background: Metastatic breast cancer to the lungs is a serious, life-threatening complication that is difficult to cure. Circulating tumor cells play a key role in the metastatic spread of breast cancer to the lungs via the lymphatic or circulatory ...
Selase Ativui, Cynthia A. Danquah, Paul Poku Sampene Ossei, Michael Ofori   +3 more
doaj   +1 more source

Comparative proteomics analysis indicates that palmatine contributes to transepithelial migration by regulating cellular adhesion

Pharmaceutical Biology, 2020
Context Palmatine, a biologically active isoquinoline alkaloid, possesses multiple pharmaceutical activities against mucosal infection and inflammation.
Wang Hui, Yang Feng, Yan Baoqi, Dong Shuwei, Xin Ruihua, He Jiongjie, Cui Dongan, Sun Yan, Zhang Shidong, Yan Zuoting   +9 more
doaj   +1 more source

The Influence of Palmatine Isolated from Berberis sibirica Radix on Pentylenetetrazole-Induced Seizures in Zebrafish

Cells, 2020
Palmatine (PALM) and berberine (BERB) are widely identified isoquinoline alkaloids among the representatives of the Berberidaceae botanical family. The antiseizure activity of BERB was shown previously in experimental epilepsy models.
Kinga Gawel, Wirginia Kukula-Koch, Dorota Nieoczym, Katarzyna Stepnik, Wietske van der Ent, Nancy Saana Banono, Dominik Tarabasz, Waldemar A. Turski, Camila V. Esguerra   +8 more
doaj   +1 more source

Palmatine Protects PC12 Cells and Mice from Aβ25-35-Induced Oxidative Stress and Neuroinflammation via the Nrf2/HO-1 Pathway

Molecules, 2023
Alzheimer’s disease is a common degenerative disease which has a great impact on people’s daily lives, but there is still a certain market gap in the drug research about it. Palmatine, one of the main components of Huangteng, the rattan stem of Fibraurea
Yu Wang, Hongyan Pei, Weijia Chen, Rui Du, Jianming Li, Zhongmei He   +5 more
doaj   +1 more source

Antioxidant and anti-advanced glycation end products formation properties of palmatine [PDF]

Journal of Pharmacy & Pharmacognosy Research, 2021
Context: Oxidative stress and formation of advanced glycation end products (AGEs), due to glycation of proteins, lipids and nucleic acids are characteristic in diabetic patients.
Sharma Mridula, Wardah Siddiqui Masroor, Mellinnda Xavier, Tan Wen Hui, Hor Kuan Chan, Kavita Chirara, Okechukwu Patrick Nwabueze   +6 more
doaj  

Memory-Enhancing Activity of Palmatine in Mice Using Elevated Plus Maze and Morris Water Maze

Advances in Pharmacological Sciences, 2012
The present study was designed to evaluate the effect of palmatine on memory of Swiss young male albino mice. Palmatine (0.1, 0.5, 1 mg/kg, i.p.) and physostigmine (0.1 mg/kg, i.p.) per se were administered for 10 successive days to separate groups of ...
Dinesh Dhingra, Varun Kumar
doaj   +1 more source

Analgesic and Anti-Arthritic Potential of Methanolic Extract and Palmatine Obtained from Annona squamosa Leaves

Pharmaceuticals
Background/Objectives: Annona squamosa is used in folk medicine to treat pain and arthritis. Palmatine is an alkaloid isolated from several plants, including A. squamosa leaves.
Caren Naomi Aguero Ito, Elisangela dos Santos Procopio, Natália de Matos Balsalobre, Lucas Luiz Machado, Saulo Euclides Silva-Filho, Taíse Fonseca Pedroso, Caroline Caramano de Lourenço, Rodrigo Juliano Oliveira, Arielle Cristina Arena, Marcos José Salvador, Cândida Aparecida Leite Kassuya   +10 more
doaj   +1 more source

Comparative Studies of Palmatine with Metformin and Glimepiride on the Modulation of Insulin Dependent Signaling Pathway In Vitro, In Vivo & Ex Vivo

Pharmaceuticals, 2022
(1) Insulin resistance, a symptom of type 2 diabetes mellitus (T2DM), is caused by the inactivation of the insulin signaling pathway, which includes IRS-PI3K-IRS-1-PKC-AKT2 and GLUT4.
Okechukwu Patrick Nwabueze, Mridula Sharma, Abbirami Balachandran, Anand Gaurav, Anis Najwa Abdul Rani, Jeleń Małgorzata, Morak-Młodawska Beata, Charlie A. Lavilla, Merell P. Billacura   +8 more
doaj   +1 more source