Results 51 to 60 of about 10,438 (226)

Phytochemicals in MASLD: A Focused Review of Gut Microbiome‐Linked Mechanisms

Phytotherapy Research, EarlyView.
ABSTRACT Metabolic dysfunction‐associated steatotic liver disease (MASLD) has emerged as a major global health burden, yet effective pharmacological options remain limited. Recent advances highlight the gut microbiome as a key modulator of liver metabolism, inflammation, and fibrosis, making it a promising therapeutic target.
Jeong In Seo, Su Min Kim, Hye Hyun Yoo
wiley   +1 more source

A comparative study of alkaloid and phenolic compounds in different organs and tissues of Berberis integerrima.

PLoS ONE
Berberis integerrima Bunge is a valuable plant of the Berberidaceae family used in medicine and industry. The properties of the different parts of this plant vary and depend on the distribution of its secondary metabolites, including alkaloids and ...
Nastaran Zhaleh, Mohsen Sharifi, Elaheh Samari, Mohammad Reza Halvagar, Seyedeh Hanieh Zeidi   +4 more
doaj   +1 more source

Analysis of glutathione-S-transferases from larvae of Galleria mellonella (Lepidoptera, Pyralidae) with potential alkaloid detoxification function

Frontiers in Physiology, 2022
The greater wax moth, Galleria mellonella, is a global pest for beehives, doing damage in the larval stage. Although a significant number of studies have reported on larvae and adults, to date no effective pest control has been implemented. In this study,
Herbert Venthur, Herbert Venthur, Paula Lizana, Loreto Manosalva, Valentina Rojas, Ricardo Godoy, Adonis Rocha, Iván Aguilera, Rubén Palma-Millanao, Victor Fajardo, Andrés Quiroz, Andrés Quiroz, Ana Mutis, Ana Mutis   +13 more
doaj   +1 more source

Identification of the major chemical constituents and their metabolites in rat plasma and various organs after oral administration of effective Erxian Decoction (EXD) fraction by liquid chromatography-mass spectrometry [PDF]

, 2010
A simple and specific LC-DAD-ESI-MS/MS method has been developed and applied for the primary investigation of the chemical constituents absorbed or metabolized in vivo, after the rat oral administration of Erxian Decoction (EXD), a Chinese medicine ...
Hu, YM, Liu, Q, Sze, SCW, Tong, Y, Tsang, KW, Wang, YT, Wong, HK, Zhong, LD   +7 more
core   +1 more source

Structural modification of berberine alkaloid and their hypoglycemic activity

Journal of Functional Foods, 2014
Berberine (BBR), a major active component of natural plant product, has recently been demonstrated to be clinically effective in alleviating type 2 diabetes mellitus (T2DM). In this study, BBR and 8-alkylberberine were successively halogenated with bromine, iodine, chlorine under various conditions.
Yangping Ding, Xiaoli Ye, Jiaying Zhu, Xiaokang Zhu, Xuegang Li, Bingcan Chen   +5 more
openaire   +2 more sources

Inositol and Berberine Synergistically Reprogram Endocrine and Ovarian Metabolism in Polycystic Ovary Syndrome

Cell Proliferation, EarlyView.
In a DHEA+HFD‐induced mouse model, Ins/BBR alleviated mitochondrial defects and broadly reprogrammed metabolic landscape in granulosa cells, in specific, restoring nucleotide pools and amino acid turnover, and preventing abnormal long‐chain fatty acid accumulation.
Juan Ge, Chenxiang Zhang, Yilong Zhao, Haiyang Zhao, Shuai Zhu, Tao Tang, Guorui Zhang, Qiang Wang, Hui Wang   +8 more
wiley   +1 more source

De novo production of protoberberine and benzophenanthridine alkaloids through metabolic engineering of yeast

Nature Communications
Protoberberine alkaloids and benzophenanthridine alkaloids (BZDAs) are subgroups of benzylisoquinoline alkaloids (BIAs), which represent a diverse class of plant-specialized natural metabolites with many pharmacological properties. Microbial biosynthesis
Xiang Jiao, Xiaozhi Fu, Qishuang Li, Junling Bu, Xiuyu Liu, Otto Savolainen, Luqi Huang, Juan Guo, Jens Nielsen, Yun Chen   +9 more
doaj   +1 more source

Hepatotoxicity induced by greater celandine (Chelidonium majus L.): a review of the literature [PDF]

, 2017
The available literature assessing Chelidonium majus L. (CM) hepatotoxicity potential, and its risk to benefit assessment has been reviewed in this paper.
Busardò, F. P, DI LUCA, Natale Mario, Gentili, S, Graziano, Silvia, Mannocchi, Giulio, Marinelli, Enrico, Pantano, Flaminia   +6 more
core  

Selection of high berberine yielding phellodendron insulare nak. lines and the antimicrobial activity of their extracts [PDF]

, 2010
High berberine yielding Phellodendron insulare Nak. lines were selected by aggregate cloning method and the antimicrobial activity of their extracts was assessed. The berberine producing cork tree lines were selected by adopting a colorimetric method. In
Chandrakant Karigar, S., Dong Jin Park, ., Hyun Jin Song, ., Jae Kyung Yang, ., Kang Hoon Seok, ., Mi Jin Joeng, ., Min, J.Y., Myung Suk Choi, .   +7 more
core   +1 more source

Genomic variation drives plant flavor diversification

Journal of Integrative Plant Biology, EarlyView.
This review explains how genomic variation shapes plant flavor by altering the biosynthetic and regulatory pathways of key attributes like sweetness, acidity, bitterness, piquancy, astringency, and aroma. It also discusses how multi‐omics, AI‐assisted breeding, and gene editing can translate this knowledge into plants with improved flavor, nutrition ...
Huimin Hu, Yanwei Hao, Yiwei Zhou, Xia Zhang, Rui Xia, Pan Liao   +5 more
wiley   +1 more source