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Computational Insights into the Molecular Mechanisms of <i>Coptis chinensis</i> Franch. in Treating Chronic Atrophic Gastritis: An Integrated Network Pharmacology, Machine Learning, and Molecular Dynamics Study. [PDF]

Int J Mol Sci
Hu C, Liu Y, Ding Y, Jin Y, Han W.
europepmc   +1 more source

The Effects of Several Natural Protoberberine Alkaloids and Cinnamic Acid Derivatives Used for Traditional Medicine on the Membrane Boundary Potential and Lipid Packing Stress. [PDF]

Int J Mol Sci
Efimova SS, Zlodeeva PD, Pham QM, Trinh HTT, Le HM, Nguyen VTH, Pham LQ, Ostroumova OS.   +7 more
europepmc   +1 more source

Cheminformatics-driven discovery of natural isoquinoline alkaloid inhibitors of Beta-secretase I for Alzheimer's management. [PDF]

PLoS One
Ahmad I, Waheed S, Alotaibi BS, Abbasi SW, Khan MU, Rahman FU, Dib H, Fawy KF, Nishan U, Ali A, Zaman A, Shah M.   +11 more
europepmc   +1 more source

TCM-Derived Natural Compounds Targeting the Gut Microbiota in Metabolic Dysfunction-Associated Steatotic Liver Disease: Gut-Liver Axis Mechanisms, Safety Considerations, and Translational Challenges. [PDF]

Metabolites
Deng H, Zhang R.
europepmc   +1 more source

Editorial: Multi-target drug discovery: an opportunity for novel and repurposed bioactive compounds. [PDF]

Front Pharmacol
Mendonça-Junior FJB.
europepmc   +1 more source

Natural products modulate renal metabolic reprogramming in diabetic kidney disease. [PDF]

J Transl Int Med
Wang W, Zhu H, Zhao K, Wang X, Liang Y, Xu J, Ma X, Yu R, Liu P.   +8 more
europepmc   +1 more source

Structural modification of berberine alkaloids in relation to cytotoxic activity in vitro

Journal of Ethnopharmacology, 2000
The cytotoxicity of two protoberberine alkaloids: berberine and lincangenine, their 8-hydroxy-7,8-dihydro-derivatives and tetrahydroprotoberberine:thaicanine, was evaluated. The cellular responses through the [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide] (MTT) method were measured in Hela (uterus carcinoma), SVKO3 (ovary carcinoma),
Francisco Arvelo
exaly   +4 more sources

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Plant isoquinoline alkaloids: Advances in the chemistry and biology of berberine

European Journal of Medicinal Chemistry, 2021
Alkaloids are one of the most important classes of plant bioactives. Among these isoquinoline alkaloids possess varied structures and exhibit numerous biological activities. Basically these are biosynthetically produced via phenylpropanoid pathway. However, occasionally some mixed pathways may also occur to provide structural divergence.
Arvind Negi
exaly   +3 more sources