Inhibition of BET Proteins and Histone Deacetylase (HDACs): Crossing Roads in Cancer Therapy. [PDF]
Cancers (Basel), 2019 Manzotti G, Ciarrocchi A, Sancisi V.
europepmc +1 more source
BET Proteins Exhibit Transcriptional and Functional Opposition in the Epithelial-to-Mesenchymal Transition. [PDF]
Mol Cancer Res, 2018 Andrieu GP, Denis GV.
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An epigenetic screening determines BET proteins as targets to suppress self-renewal and tumorigenicity in canine mammary cancer cells. [PDF]
Sci Rep, 2019 Xavier PLP +7 more
europepmc +1 more source
Intron 1-Mediated Regulation of EGFR Expression in EGFR-Dependent Malignancies Is Mediated by AP-1 and BET Proteins. [PDF]
Mol Cancer Res, 2019 Jameson NM +7 more
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Histone acetylation, BET proteins, and periodontal inflammation
Molecular Oral Microbiology, 2023AbstractPeriodontitis is one of the most common inflammatory diseases in humans. The susceptibility to periodontitis is largely determined by the host response, and the severity of inflammation predicts disease progression. Upon microbial insults, host cells undergo massive changes in their transcription program to trigger an appropriate response ...
Nicholas, Clayton +2 more
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BET proteins: Biological functions and therapeutic interventions
Pharmacology & Therapeutics, 2023Bromodomain and extra-terminal (BET) family member proteins (BRD2, BRD3, BRD4 and BRDT) play a pivotal role in interpreting the epigenetic information of histone Kac modification, thus controlling gene expression, remodeling chromatin structures and avoid replicative stress-induced DNA damages.
Jiawei, Guo, Qingquan, Zheng, Yong, Peng
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BET Proteins as Targets for Anticancer Treatment
Cancer Discovery, 2018AbstractBromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate gene expression and are involved in cancer pathogenesis. Over the last years, several BET inhibitors have been developed and clinically tested. Results from the first clinical trials show limited single-agent activity in a small subset of patients with ...
Anastasios, Stathis, Francesco, Bertoni
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Therapeutic targeting of BET protein BRD4 delays murine lupus
International Immunopharmacology, 2015BRD4 is a member of the BET (bromodomain and extraterminal domain) family proteins that can bind acetylated histones and influence transcription, which are considered as potential therapeutic targets in many distinct diseases. And the BET inhibitor JQ1 has been proven to be effective in suppressing multiple inflammatory and autoimmune diseases.
Shitong, Wei, Yonghua, Sun, Hongyu, Sha
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Role of BET proteins in castration-resistant prostate cancer
Drug Discovery Today: Technologies, 2016Castration resistant prostate cancer (CRPC) is a deadly disease with few therapeutic options once patients become resistant to second generation drugs targeting the AR-transcriptional program. The BET-BRD readers of chromatin are key regulators of AR-, ERG-, and c-Myc-mediated transcription in CRPC.
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