Results 11 to 20 of about 104,722 (190)

Editorial: BET proteins in chromatin architecture, transcription and disease [PDF]

Frontiers in Molecular Biosciences, 2022
Amit Kumar Singh, Sheetal Uppal, Sheetal Uppal, Keiko Ozato, Dinah S. Singer, Ballachanda N. Devaiah   +5 more
doaj   +4 more sources

The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands [PDF]

BMC Evolutionary Biology, 2008
Background The major birch pollen allergen, Bet v 1, is a member of the ubiquitous PR-10 family of plant pathogenesis-related proteins. In recent years, a number of diverse plant proteins with low sequence similarity to Bet v 1 was identified.
Breiteneder Heimo, Lackner Peter, Radauer Christian   +2 more
doaj   +4 more sources

BET proteins are essential for the specification and maintenance of the epiblast lineage in mouse preimplantation embryos [PDF]

BMC Biology, 2022
Background During mammalian preimplantation development, as the fertilized egg develops and differentiates, three cell lineages become specified: trophectoderm (TE), epiblast, and primitive endoderm (PrE).
Mami Tsume-Kajioka, Chiharu Kimura-Yoshida, Kyoko Mochida, Yoko Ueda, Isao Matsuo   +4 more
doaj   +2 more sources

PCNA Unloading Is Negatively Regulated by BET Proteins

Cell Reports, 2019
Summary: Proliferating cell nuclear antigen (PCNA) is a DNA clamp essential for DNA replication. During DNA synthesis, PCNA is continuously loaded onto and unloaded from DNA.
Mi-Sun Kang, Jinwoo Kim, Eunjin Ryu, Na Young Ha, Sunyoung Hwang, Byung-Gyu Kim, Jae Sun Ra, Yeong Jae Kim, Jung Me Hwang, Kyungjae Myung, Sukhyun Kang   +10 more
doaj   +4 more sources

Altered regulation and expression of genes by BET family of proteins in COPD patients. [PDF]

PLoS ONE, 2017
BackgroundBET proteins (BRD2, BRD3, BRDT and BRD4) belong to the family of bromodomain containing proteins, which form a class of transcriptional co-regulators.
Rajneesh Malhotra, Nisha Kurian, Xiao-Hong Zhou, Fanyi Jiang, Susan Monkley, Amy DeMicco, Ib G Clausen, Göran Dellgren, Goran Edenro, Miika J Ahdesmäki, Maryam Clausen, Lisa Öberg, Elisabeth Israelsson, Graham Belfield, Outi Vaarala   +14 more
doaj   +3 more sources

BET Proteins as Attractive Targets for Cancer Therapeutics. [PDF]

Int J Mol Sci, 2021
Transcriptional dysregulation is a hallmark of cancer and can be an essential driver of cancer initiation and progression. Loss of transcriptional control can cause cancer cells to become dependent on certain regulators of gene expression. Bromodomain and extraterminal domain (BET) proteins are epigenetic readers that regulate the expression of ...
Sarnik J, Popławski T, Tokarz P.
europepmc   +4 more sources

Therapeutic Targeting of BET Proteins in Sarcoma. [PDF]

Mol Cancer Ther
Abstract Bromodomain and extraterminal (BET) domain protein family are epigenetic readers that regulate gene transcription, cell-cycle progression, and DNA damage response (DDR), making them attractive therapeutic targets for sarcomas, which are epigenetically dysregulated and genomically unstable.
Riyahi N, Malko R, Shannon HE, Jackson KW, Justice RE, Kreklau K, Saadatzadeh MR, Pollok KE, Pandya PH.   +8 more
europepmc   +3 more sources

BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis

Scientific Reports, 2017
Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure.
Thomas C. Roberts, Usue Etxaniz, Alessandra Dall’Agnese, Shwu-Yuan Wu, Cheng-Ming Chiang, Paul E. Brennan, Matthew J. A. Wood, Pier Lorenzo Puri   +7 more
doaj   +4 more sources

A Comprehensive Review of BET Protein Biochemistry, Physiology, and Pathological Roles

Frontiers in Pharmacology, 2022
Epigenetic modifications, specifically acetylation of histone plays a decisive role in gene regulation and transcription of normal cellular mechanisms and pathological conditions.
Hafiz Akbar Ali, Hafiz Akbar Ali, Yalan Li, Akram Hafiz Muhammad Bilal, Tingting Qin, Ziqiao Yuan, Wen Zhao, Wen Zhao   +7 more
doaj   +1 more source

Targeting bromodomain and extra-terminal proteins to inhibit neuroblastoma tumorigenesis through regulating MYCN

Frontiers in Cell and Developmental Biology, 2022
Bromodomain and extra-terminal domain (BET) family proteins play important roles in regulating the expression of multiple proto-oncogenes by recognizing acetylation of histones and non-histone proteins including transcription factors, which subsequently ...
Xiyao Shi, Xiyao Shi, Ying Wang, Longhui Zhang, Longhui Zhang, Wenjie Zhao, Wenjie Zhao, Xiangpeng Dai, Xiangpeng Dai, Yong-Guang Yang, Yong-Guang Yang, Yong-Guang Yang, Xiaoling Zhang, Xiaoling Zhang   +13 more
doaj   +1 more source