Results 21 to 30 of about 104,722 (190)
BET Protein-Mediated Transcriptional Regulation in Heart Failure [PDF]
International Journal of Molecular Sciences, 2021 Heart failure is a complex disease process with underlying aberrations in neurohormonal systems that promote dysregulated cellular signaling and gene transcription. Over the past 10 years, the advent of small-molecule inhibitors that target transcriptional machinery has demonstrated the importance of the bromodomain and extraterminal (BET) family of ...
Talha Ijaz, Michael A. Burke
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Bromodomain protein BRD4 is an epigenetic activator of B7-H6 expression in acute myeloid leukemia
OncoImmunology, 2021 B7-H6, a ligand for the NK activating receptor NKp30, has been identified as a biomarker of poor prognosis in several solid cancers. However, little is known about the role of B7-H6 and the mechanisms that control its expression in acute myeloid leukemia
Aroa Baragaño Raneros +7 more
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BET Epigenetic Reader Proteins in Cardiovascular Transcriptional Programs [PDF]
Circulation Research, 2020 Epigenetic mechanisms involve the placing (writing) or removal (erasing) of histone modifications that allow heterochromatin to transition to the open, activated euchromatin state necessary for transcription. A third, less studied epigenetic pathway involves the reading of these specific histone marks once placed.
Patricia Cristine Borck +2 more
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BET Bromodomain Inhibitors: Novel Design Strategies and Therapeutic Applications
Molecules, 2023 The mammalian bromodomain and extra-terminal domain (BET) family of proteins consists of four conserved members (Brd2, Brd3, Brd4, and Brdt) that regulate numerous cancer-related and immunity-associated genes.
Kenneth K. W. To +3 more
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Roles of Bromodomain Extra Terminal Proteins in Metabolic Signaling and Diseases
Pharmaceuticals, 2022 BET proteins, which recognize and bind to acetylated histones, play a key role in transcriptional regulation. The development of chemical BET inhibitors in 2010 greatly facilitated the study of these proteins.
Dayu Wu, Qiong Duan
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BET Bromodomain Proteins as Cancer Therapeutic Targets [PDF]
Cold Spring Harbor Symposia on Quantitative Biology, 2016 Epigenetic regulators are emerging therapeutic targets in a wide variety of human cancers. BET bromodomain proteins have been identified as key regulators of oncogenic transcription factors including MYC; therefore, their inhibition might provide a way to block these "undruggable" targets.
Shaokun, Shu, Kornelia, Polyak
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BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice [PDF]
Nature Neuroscience, 2015 Precise regulation of transcription is crucial for the cellular mechanisms underlying memory formation. However, the link between neuronal stimulation and the proteins that directly interact with histone modifications to activate transcription in neurons remains unclear. Brd4 is a member of the bromodomain and extra-terminal domain (BET) protein family,
Erica Korb +4 more
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Frontiers in Molecular Biosciences, 2020 Bromodomain and extra-terminal domain (BET) family proteins have become a hot research area because of their close relationship with a variety of human diseases.
Ping Bai +9 more
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Relevance of BET Family Proteins in SARS-CoV-2 Infection
Biomolecules, 2021 The recent pandemic we are experiencing caused by the coronavirus disease 2019 (COVID-19) has put the world’s population on the rack, with more than 191 million cases and more than 4.1 million deaths confirmed to date.
Nieves Lara-Ureña +1 more
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Inhibition of bromodomain and extra-terminal (BET) proteins increases NKG2D ligand MICA expression and sensitivity to NK cell-mediated cytotoxicity in multiple myeloma cells. role of cMYC-IRF4-miR-125b interplay [PDF]
, 2016 Background: Anticancer immune responses may contribute to the control of tumors after conventional chemotherapy and different observations have indicated that chemotherapeutic agents can induce immune responses resulting in cancer cell death and immune ...
Abruzzese, MARIA PIA +13 more
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