Results 31 to 40 of about 174,626 (254)

Antibiotic-Induced Disruption of Gut Microbiota Alters Local Metabolomes and Immune Responses

Frontiers in Cellular and Infection Microbiology, 2019
Gut microbiome plays an essential role in modulating host immune responses. However, little is known about the interaction of microbiota, their metabolites and relevant inflammatory responses in the gut.
Lin Sun, Lin Sun, Xiaoyan Zhang, Yuxiao Zhang, Kai Zheng, Qiaoyan Xiang, Ning Chen, Zhiyun Chen, Nan Zhang, Junping Zhu, Qiushui He, Qiushui He   +11 more
doaj   +1 more source

Sevoflurane alleviates liver ischemia reperfusion injury through inactivation of the TRAF6/NF-κB signaling pathway

Tropical Journal of Pharmaceutical Research, 2021
Purpose: To evaluate the role and mechanism of action of sevoflurane in liver ischemia reperfusion injury.Methods: Rats were pretreated with sevoflurane and then underwent liver ischemia followed by reperfusion to establish an animal model of liver ...
Hongqiang Liu, Ying-Ying Yuan, D. Rao
semanticscholar   +1 more source

Copper-Induced Ionoregulatory Disturbance, Histopathology, and Transcriptome Responses in Freshwater Mussel (Anodonta woodiana) Gills

Fishes, 2023
Copper (Cu) contamination has become a severe problem in freshwater environments worldwide. The freshwater mussel Anodonta woodiana is used as a unique bioindicator to monitor Cu contamination in freshwater environments. However, Cu toxicity and response
Xiubao Chen, Hongbo Liu, Karsten Liber, Tao Jiang, Jian Yang   +4 more
doaj   +1 more source

Lycopene-Loaded Bilosomes Ameliorate High-Fat Diet-Induced Chronic Nephritis in Mice through the TLR4/MyD88 Inflammatory Pathway

Foods, 2022
Chronic kidney disease caused by a high-fat diet (HFD)-induced metabolic syndrome has received widespread attention. Lycopene has a wide range of biological activities and can improve a variety of chronic diseases through anti-inflammatory effects.
Chang Liu, Yu Liu, Ciwan Wang, Yahui Guo, Yuliang Cheng, He Qian, Yong Zhao   +6 more
doaj   +1 more source

Metabolomic profiling in kidney cells treated with a sodium glucose-cotransporter 2 inhibitor

Scientific Reports, 2023
We aimed to determine the metabolomic profile of kidney cells under high glucose conditions and following sodium-glucose cotransporter 2 (SGLT2) inhibitor treatment.
Hyung Ah Jo, Jong-Hyun Seo, Sunhwa Lee, Mi-yeon Yu, Eunjin Bae, Dong Ki Kim, Yon Su Kim, Da Jung Kim, Seung Hee Yang   +8 more
doaj   +1 more source

Metabolic Engineering of Yeast for the Production of 3-Hydroxypropionic Acid

Frontiers in Microbiology, 2018
The beta-hydroxy acid 3-hydroxypropionic acid (3-HP) is an attractive platform compound that can be used as a precursor for many commercially interesting compounds.
Rong-Yu Ji, Ying Ding, Tian-Qiong Shi, Lu Lin, He Huang, He Huang, He Huang, Zhen Gao, Xiao-Jun Ji, Xiao-Jun Ji   +9 more
doaj   +1 more source

Identification of Metabolic Signature Associated with Idiopathic Inflammatory Myopathy Reveals Polyamine Pathway Alteration in Muscle Tissue

Metabolites, 2022
Idiopathic inflammatory myopathy (IIM) is hard to diagnose without a muscle biopsy. We aimed to identify a metabolite panel for IIM detection by metabolomics approach in serum samples and to explore the metabolomic signature in tissue samples from a ...
Jihyun Kang, Jeong Yeon Kim, Youjin Jung, Seon Uk Kim, Eun Young Lee, Joo-Youn Cho   +5 more
doaj   +1 more source

Integrin beta 4 (ITGB4) and its tyrosine-1510 phosphorylation promote pancreatic tumorigenesis and regulate the MEK1-ERK1/2 signaling pathway

Bosnian Journal of Basic Medical Sciences, 2019
Pancreatic cancer is the fourth leading cause of cancer death, with a 5-year survival rate of only 1–4%. Integrin-mediated cell adhesion is critical for the initiation, progression, and metastasis of cancer.
Xiangli Meng, Peng Liu, Yunhao Wu, Xinlu Liu, Yinpeng Huang, Boqiang Yu, Jiahong Han, Haoyi Jin, Xiaodong Tan   +8 more
semanticscholar   +1 more source

The Role of Wnt/beta-Catenin Signal Pathway in the Pathogenesis of Nonalcoholic Fatty Liver Disease and the Effect of Atorvastatin Intervention

, 2020
The purpose of this study was to analyze the pathogenesis of nonalcoholic fatty liver disease in rats and study the efficacy of atorvastatin intervention. One hundred Sprague Dawley rats were selected as test system. These rats were randomly divided into
X. Sui, H. Deng, T. Li, T. Liu
semanticscholar   +1 more source

Downregulation of hepatic METTL3 contributes to APAP-induced liver injury in mice

JHEP Reports, 2023
Background & Aims: Acetaminophen (APAP) overdose is a major cause of acute liver failure in the Western world, but its molecular mechanisms are not fully understood.
Chunhong Liu, Xinzhi Li, Ming Gao, Yanbin Dong, Zheng Chen   +4 more
doaj   +1 more source