Results 11 to 20 of about 174,626 (254)

Integration of Proteomics and Metabolomics Into the Design, Build, Test, Learn Cycle to Improve 3-Hydroxypropionic Acid Production in Aspergillus pseudoterreus

Frontiers in Bioengineering and Biotechnology, 2021
Biological engineering of microorganisms to produce value-added chemicals is a promising route to sustainable manufacturing. However, overproduction of metabolic intermediates at high titer, rate, and yield from inexpensive substrates is challenging in ...
Kyle R. Pomraning, Ziyu Dai, Nathalie Munoz, Young-Mo Kim, Yuqian Gao, Shuang Deng, Joonhoon Kim, Joonhoon Kim, Beth A. Hofstad, Marie S. Swita, Teresa Lemmon, James R. Collett, Ellen A. Panisko, Bobbie-Jo M. Webb-Robertson, Jeremy D. Zucker, Carrie D. Nicora, Henrique De Paoli, Scott E. Baker, Kristin E. Burnum-Johnson, Nathan J. Hillson, Jon K. Magnuson, Jon K. Magnuson   +21 more
doaj   +1 more source

Short Report: Using Targeted Urine Metabolomics to Distinguish Between Manganese Exposed and Unexposed Workers in a Small Occupational Cohort

Frontiers in Public Health, 2021
Objectives: Despite the widespread use of manganese (Mn) in industrial settings and its association with adverse neurological outcomes, a validated and reliable biomarker for Mn exposure is still elusive.
Kayla A. Carter, Christopher D. Simpson, Daniel Raftery, Marissa G. Baker   +3 more
doaj   +1 more source

Saccharomyces cerevisiae Is Capable of de Novo Pantothenic Acid Biosynthesis Involving a Novel Pathway of β-Alanine Production from Spermine [PDF]

Journal of Biological Chemistry, 2001
Pantothenic acid and beta-alanine are metabolic intermediates in coenzyme A biosynthesis. Using a functional screen in the yeast Saccharomyces cerevisiae, a putative amine oxidase, encoded by FMS1, was found to be rate-limiting for beta-alanine and pantothenic acid biosynthesis.
W H, White, P L, Gunyuzlu, J H, Toyn
openaire   +2 more sources

Differential Expression and Correlation Analysis of Global Transcriptome for Hemorrhagic Transformation After Acute Ischemic Stroke

Frontiers in Neuroscience, 2022
In order to explore the epigenetic characteristics of hemorrhagic transformation (HT) after acute ischemic stroke, we used transcriptome sequencing technology to analyze the global transcriptome expression profile of patients with and without HT after ...
Rongrong Han, Peng Zhang, Hongfang Li, Yun Chen, Yongnan Hao, Qiang Guo, Aimei Zhang, Daojing Li   +7 more
doaj   +1 more source

Serum kynurenine and beta-alanine levels are associated with Wnt pathway gene expression in leukocytes of patients with Parkinson's disease

, 2023
Abstract Background: Parkinson's disease (PD) is the second most common neurodegenerative disease in the world. Despite its worldwide prevalence, there is currently no clear explanation of the mechanism of this disease. Moreover, the lack of reliable and accurate biomarkers makes the early detection of PD difficult.
Afsaneh Hajihassani, Alireza Nourazarian, Masoud Nikanfar, Delara Laghousi, Fatemeh Khaki-Khatibi   +4 more
openaire   +1 more source

The biotoxin BMAA promotes dysfunction via distinct mechanisms in neuroblastoma and glioblastoma cells

PLoS ONE, 2023
Chronic exposure to the Cyanobacteria biotoxin Beta-methylamino-L-alanine (BMAA) has been associated with development of a sporadic form of ALS called Amyotrophic Lateral Sclerosis/Parkinsonism-Dementia Complex (ALS/PDC), as observed within certain ...
Bryan Burton, Kate Collins, Jordan Brooks, Karly Marx, Abigail Renner, Kaylei Wilcox, Ellie Moore, Keith Osowski, Jordan Riley, Jarron Rowe, Matthew Pawlus   +10 more
doaj   +2 more sources

Transcriptome and metabolome analyses reveal the regulatory effects of compound probiotics on cecal metabolism in heat-stressed broilers

Poultry Science, 2023
: The effect of compound probiotics on the caecum of broilers under heat stress was assessed in this study. A total of 400 twenty-eight-day-old AA male broilers were randomly divided into 4 treatment groups, where each group had 5 replicates of 20 ...
Lihuan Zhang, Yanfei Wang, Hao Jia, Xuan Liu, Ruonan Zhang, Jiawei Guan   +5 more
doaj   +1 more source

Establishing a synthetic pathway for high-level production of 3-hydroxypropionic acid in Saccharomyces cerevisiae via β-alanine [PDF]

Metabolic Engineering, 2015
Microbial fermentation of renewable feedstocks into plastic monomers can decrease our fossil dependence and reduce global CO2 emissions. 3-Hydroxypropionic acid (3HP) is a potential chemical building block for sustainable production of superabsorbent polymers and acrylic plastics.
Borodina, Irina, Kildegaard, Kanchana R, Jensen, Niels B, Blicher, Thomas H, Maury, Jérôme, Sherstyk, Svetlana, Schneider, Konstantin, Lamosa, Pedro, Herrgård, Markus J, Rosenstand, Inger, Oberg, Fredrik, Forster, Jochen, Nielsen, Jens   +12 more
openaire   +4 more sources

Multi-timescale analysis of a metabolic network in synthetic biology: a kinetic model for 3-hydroxypropionic acid production via beta-alanine

Journal of Mathematical Biology, 2017
A biosustainable production route for 3-hydroxypropionic acid (3HP), an important platform chemical, would allow 3HP to be produced without using fossil fuels. We are interested in investigating a potential biochemical route to 3HP from pyruvate through $
M. Dalwadi, J. King, N. Minton
semanticscholar   +2 more sources

Metabolic engineering to improve production of 3-hydroxypropionic acid from corn-stover hydrolysate in Aspergillus species

Biotechnology for Biofuels and Bioproducts, 2023
Background Fuels and chemicals derived from non-fossil sources are needed to lessen human impacts on the environment while providing a healthy and growing economy.
Ziyu Dai, Kyle R. Pomraning, Shuang Deng, Joonhoon Kim, Kristen B. Campbell, Ana L. Robles, Beth A. Hofstad, Nathalie Munoz, Yuqian Gao, Teresa Lemmon, Marie S. Swita, Jeremy D. Zucker, Young-Mo Kim, Kristin E. Burnum-Johnson, Jon K. Magnuson   +14 more
doaj   +1 more source