Results 21 to 30 of about 174,626 (254)

Does Acute Beta-alanine Supplementation Improve Performance, Rating Of Perceived Exertion And Heart Rate During Hiking?

, 2020
TP scores for that subtest. TP scores were multiplied by their relative weights, and the values summed to provide a value for COG. Assessments occurred at baseline (0H), 12-hours (12H), 18hours (18H) and 24-hours (24H).
Bryson Carrier
semanticscholar   +1 more source

ABAT gene expression associated with the sensitivity of hypomethylating agents in myelodysplastic syndrome through CXCR4/mTOR signaling

Cell Death Discovery, 2022
The factors that affect hypomethylating agents (HMAs) sensitivity in myelodysplastic syndrome (MDS) are complex and multifaceted. They include DNA methylation, gene expression, mutation, etc.
Guangjie Zhao, Shuang Li, Qian Wang, Wanlin Wu, Xuewei Fu, Chen Zhu, Wei Wang, Xiaoqin Wang   +7 more
doaj   +1 more source

Alteration of metabolite profiling by cold atmospheric plasma treatment in human myeloma cells

Cancer Cell International, 2018
Background Despite new progress of chemotherapy in multiple myeloma (MM) clinical treatment, MM is still a refractory disease and new technology is needed to improve the outcomes and prolong the survival.
Dehui Xu, Yujing Xu, Ning Ning, Qingjie Cui, Zhijie Liu, Xiaohua Wang, Dingxin Liu, Hailan Chen, Michael G. Kong   +8 more
doaj   +1 more source

ApoSOD1 lacking dismutase activity neuroprotects motor neurons exposed to beta-methylamino-L-alanine through the Ca2+/Akt/ERK1/2 prosurvival pathway

Cell Death and Differentiation, 2017
Amyotrophic lateral sclerosis (ALS) is a severe human adult-onset neurodegenerative disease affecting lower and upper motor neurons. In >20% of cases, the familial form of ALS is caused by mutations in the gene encoding Cu,Zn-superoxide dismutase (SOD1).
Tiziana Petrozziello, A. Secondo, Valentina Tedeschi, A. Esposito, M. Sisalli, A. Scorziello, G. di Renzo, L. Annunziato   +7 more
semanticscholar   +1 more source

A polysaccharide from Codonopsis pilosula roots attenuates carbon tetrachloride-induced liver fibrosis via modulation of TLR4/NF-κB and TGF-β1/Smad3 signaling pathway.

International Immunopharmacology, 2023
The present work reported the extraction, purification, characterization of a polysaccharide from roots of Codonopsis pilosula (CPP-A-1) and its effect on liver fibrosis.
Xianqun Meng, Haixue Kuang, Qiuhong Wang, Hui Zhang, Dan Wang, Tingguo Kang   +5 more
semanticscholar   +1 more source

Integrated proteomics and metabolomics analysis of lumbar in a rat model of osteoporosis treated with Gushukang capsules

BMC Complementary Medicine and Therapies, 2022
Background Gushukang (GSK) capsules are a Chinese patented medicine that is widely used in clinics for the treatment of osteoporosis (OP). Animal experiments have revealed that the bone mineral density of osteoporotic rats increase after treatment with ...
Ruohui Lin, Bingying Xie, Lihua Xie, Jirong Ge, Shengqiang Li   +4 more
doaj   +1 more source

Shikonin Attenuates Acetaminophen-Induced Hepatotoxicity by Upregulation of Nrf2 through Akt/GSK3β Signaling

Molecules, 2018
Acetaminophen (APAP) overdose-induced acute liver damage is mostly due to overwhelmingly increased oxidative stress. Nuclear factor-erythroid 2-related factor2 (Nrf2) plays an important role in alleviating APAP hepatic toxicity.
Huachao Li, Yueming Chen, Jiahao Zhang, Xiangcui Chen, Zheng Li, Bing Liu, Luyong Zhang   +6 more
doaj   +1 more source

The Protective Effect of Aspirin Eugenol Ester on Paraquat-Induced Acute Liver Injury Rats

Frontiers in Medicine, 2020
Aspirin eugenol ester (AEE) possesses anti-inflammatory and anti-oxidative effects. The study was conducted to evaluate the protective effect of AEE on paraquat-induced acute liver injury (ALI) in rats.
Zhen-Dong Zhang, Ya-Jun Yang, Xi-Wang Liu, Zhe Qin, Shi-Hong Li, Jian-Yong Li   +5 more
doaj   +1 more source

Subtractive genomics and molecular docking approach to identify drug targets against Stenotrophomonas maltophilia.

PLoS ONE, 2021
Stenotrophomonas maltophilia is a multidrug resistant pathogen associated with high mortality and morbidity in patients having compromised immunity. The efflux systems of S.
Hira Saleem, Usman Ali Ashfaq, Habibullah Nadeem, Muhammad Zubair, Muhammad Hussnain Siddique, Ijaz Rasul   +5 more
doaj   +1 more source

MiR-29a Family as a Key Regulator of Skeletal Muscle Dysplasia in a Porcine Model of Intrauterine Growth Retardation

Biomolecules, 2022
MicroRNAs (miRNAs) play an essential role in many biological processes. In this study, miRNAs in the skeletal muscle of normal and intrauterine growth retardation (IUGR) neonatal piglets were identified by sequencing, and canonical miRNAs were ...
Yan Zhu, Jianfeng Ma, Hongmei Pan, Mailin Gan, Linyuan Shen   +4 more
doaj   +1 more source