Results 31 to 40 of about 1,106,914 (319)
Expression of dickkopf-1 and beta-catenin related to the prognosis of breast cancer patients with triple negative phenotype. [PDF]
PLoS ONE, 2012 BACKGROUND AND AIM: We investigated the prognostic importance of dickkopf-1(DKK1) and beta-catenin expression in triple negative breast cancers. METHODS: The expression of DKK1 and beta-catenin was evaluated in breast cell lines using RT-PCR and western ...
Wen-Huan Xu +4 more
doaj +1 more source
Wnt/beta-catenin pathway: modulating anticancer immune response
Journal of Hematology & Oncology, 2017 Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal.
S. Pai +8 more
semanticscholar +1 more source
MicroRNA roles in beta-catenin pathway [PDF]
Molecular Cancer, 2010 Abstractβ-catenin, a key factor in the Wnt signaling pathway, has essential functions in the regulation of cell growth and differentiation. Aberrant β-catenin signaling has been linked to various disease pathologies, including an important role in tumorigenesis.
Han Lei +6 more
openaire +3 more sources
HGF/c-Met related activation of β-catenin in hepatoblastoma
Journal of Experimental & Clinical Cancer Research, 2011 Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton +6 more
doaj +1 more source
A lentivirus-mediated genetic screen identifies dihydrofolate reductase (DHFR) as a modulator of beta-catenin/GSK3 signaling. [PDF]
PLoS ONE, 2009 The multi-protein beta-catenin destruction complex tightly regulates beta-catenin protein levels by shuttling beta-catenin to the proteasome. Glycogen synthase kinase 3beta (GSK3beta), a key serine/threonine kinase in the destruction complex, is ...
Richard A Klinghoffer +10 more
doaj +1 more source
PPAR Research, 2017 In both colon cancer and type 2 diabetes, metabolic changes induced by upregulation of the Wnt/beta-catenin signaling and downregulation of peroxisome proliferator-activated receptor gamma (PPAR gamma) may help account for the frequent association of ...
Y. Lecarpentier +3 more
semanticscholar +1 more source
OncoTarget, 2017 The underlying mechanism of Fusobacterium nucleatum (Fn) in the carcinogenesis of colorectal cancer (CRC) is poorly understood. Here, we examined Fn abundance in CRC tissues, as well as β-catenin, TLR4 and PAK1 protein abundance in Fn positive and Fn ...
Yongyu Chen +8 more
semanticscholar +1 more source
Beta-Catenin in Pseudoexfoliation Syndrome [PDF]
Applied Sciences, 2020 To find whether it is possible that beta-catenin, associated with the development of serious systemic diseases, as well as the neoplastic process, plays a role in the development of pseudoexfoliation syndrome (PEX). If so, identifying PEX, an age-related, vision-threatening disorder of elastic fibers, which is manifested in eyes by the accumulation of ...
Joanna Stafiej +5 more
openaire +2 more sources
Regulation of slow and fast muscle myofibrillogenesis by Wnt/beta-catenin and myostatin signaling. [PDF]
PLoS ONE, 2009 Deviation from proper muscle development or homeostasis results in various myopathic conditions. Employing genetic as well as chemical intervention, we provide evidence that a tight regulation of Wnt/beta-catenin signaling is essential for muscle fiber ...
Jin-Ming Tee +3 more
doaj +1 more source
Functional Wnt signaling is increased in idiopathic pulmonary fibrosis. [PDF]
PLoS ONE, 2008 BackgroundIdiopathic pulmonary fibrosis (IPF) is a fatal lung disease, characterized by distorted lung architecture and loss of respiratory function.
Melanie Königshoff +6 more
doaj +1 more source