Results 21 to 30 of about 154,226 (253)

Beta-lactam-specific resistant mutants of Staphylococcus aureus [PDF]

Antimicrobial Agents and Chemotherapy, 1986
In an approach to understanding the origin of methicillin resistance in clinical isolates of staphylococci, a series of Staphylococcus aureus mutants resistant to various beta-lactam antibiotics were isolated in the laboratory by antibiotic selection. Mutants with low- and intermediate-level resistance showed considerable specificity for the particular
TONIN, ENRICO ANGELO, TOMASZ A.
openaire   +3 more sources

Evaluation of the ESBL-coding plasmids transmissibility in E. coli isolated from ambulatory patient's urina [PDF]

, 2018
Representatives of the Enterobacteriaceae family are the main causative agents of urinary tract infections. Escherichia coli can exhibit resistance to [beta] -lactam antibiotics by synthesizing ESBL (extended spectrum [beta]-lactamases).
Катаева, Е. И.
core   +2 more sources

The reaction mechanism of metallo-beta-lactamases is tuned by the conformation of an active site mobile loop [PDF]

, 2018
Carbapenems are "last resort" β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria.
Alzari, Pedro M., Bethel, Christopher R., Bonomo, Robert A., Giannini, Estefanía, Klinke, Sebastian, Llarrull, Leticia Irene, Mojica, María F., Otero, Lisandro Horacio, Palacios, Antonela Rocio, Taracila, Magdalena A., Vila, Alejandro Jose   +10 more
core   +1 more source

Comprehensive Identification of Single Nucleotide Polymorphisms Associated with Beta-lactam Resistance within Pneumococcal Mosaic Genes

PLoS Genetics, 2014
Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks, confounding the identification of causative variants.
C. Chewapreecha, Pekka Marttinen, N. Croucher, S. Salter, S. Harris, A. Mather, W. Hanage, D. Goldblatt, F. Nosten, C. Turner, P. Turner, S. Bentley, J. Parkhill   +12 more
semanticscholar   +1 more source

Multilocus sequence typing and ftsI sequencing: a powerful tool for surveillance of penicillin-binding protein 3-mediated beta-lactam resistance in nontypeable Haemophilus influenzae

BMC Microbiology, 2014
BackgroundBeta-lactam resistance in Haemophilus influenzae due to ftsI mutations causing altered penicillin-binding protein 3 (PBP3) is increasing worldwide.
D. Skaare, I. Anthonisen, D. Caugant, A. Jenkins, M. Steinbakk, L. Strand, A. Sundsfjord, Y. Tveten, B. Kristiansen   +8 more
semanticscholar   +1 more source

Penicillin-binding proteins and beta-lactam resistance.

FEMS Microbiology Reviews, 2008
A number of ways and means have evolved to provide resistance to eubacteria challenged by beta-lactams. This review is focused on pathogens that resist by expressing low-affinity targets for these antibiotics, the penicillin-binding proteins (PBPs). Even
A. Zapun, C. Contreras-Martel, T. Vernet
semanticscholar   +1 more source

Penicillin Allergy Assessment and Skin Testing in the Outpatient Setting [PDF]

, 2019
Penicillin allergies are among of the most commonly reported allergies, yet only 10% of these patients are truly allergic. This leads to potential inadvertent negative consequences for patients and makes treatment decisions challenging for clinicians ...
Avery, Lisa M., Bookstaver, P. Brandon, Justo, Julie Ann, Kufel, Wesley D.   +3 more
core   +3 more sources

The Mechanism of Heterogeneous Beta-Lactam Resistance in MRSA: Key Role of the Stringent Stress Response

PLoS ONE, 2013
All methicillin resistant S. aureus (MRSA) strains carry an acquired genetic determinant – mecA or mecC - which encode for a low affinity penicillin binding protein –PBP2A or PBP2A′ – that can continue the catalysis of peptidoglycan transpeptidation in ...
Choonkeun Kim, Michael M. Mwangi, M. Chung, Catarina Milheirço, H. de Lencastre, A. Tomasz   +5 more
semanticscholar   +1 more source

The Distribution of ESBL-Producing Enterobacteriaceae: Leicestershire UK Compared to Worldwide [PDF]

, 2019
open access ...
Reid, R., Samarasinghe, S., Varnakulasingam, Atheena   +2 more
core   +1 more source

Differential DNA accessibility to polymerase enables 30-minute phenotypic β-lactam antibiotic susceptibility testing of carbapenem-resistant Enterobacteriaceae [PDF]

, 2020
The rise in carbapenem-resistant Enterobacteriaceae (CRE) infections has created a global health emergency, underlining the critical need to develop faster diagnostics to treat swiftly and correctly.
Garner, Omai B., Ismagilov, Rustem F., Liaw, Eric J., Savela, Emily S., Schoepp, Nathan G., Winnett, Alexander   +5 more
core   +1 more source