Results 21 to 30 of about 2,940,166 (197)

Mechanism of resistance to beta-lactam antibiotics

BULLETIN of the L.N. Gumilyov Eurasian National University. BIOSCIENCE Series, 2023
Acinetobacter baumannii is the most commonly associated human pathogen with infections in the genus. This opportunistic pathogen causes quite serious infections, especially in fond patients, and has the ability to quickly develop resistance to new antibiotics. In the recent past, carbapenems, a.
R. Khalilov, M. Mammadova, Sh. Abdullayeva   +2 more
openaire   +1 more source

Uncovering Beta-Lactam Susceptibility Patterns in Clinical Isolates of Mycobacterium tuberculosis through Whole-Genome Sequencing [PDF]

, 2022
The increasing threat of drug resistance and a stagnated pipeline of novel therapeutics endanger the eradication of tuberculosis. Beta-lactams constitute promising additions to the current therapeutic arsenal and two carbapenems are included in group C ...
Olivença, Francisco, Silveiro, Cátia, Catalão, Maria João, Miragaia, Maria, Gomes, João Paulo, Nunes, Alexandra, Macedo, Rita, Pires, David, Anes, Elsa   +8 more
core   +1 more source

Historical Review of the Penicillin and Related Compounds (β – Lactams)

Al-Mustansiriyah Journal of Pharmaceutical Sciences, 2018
In spite of  the old age of beta lactam, they continue to provide good health and preventing human diseases by virtue of  industrial production and discoveries of small new beta-lactam group of secondary metabolite.
Luma Salman Abd
doaj   +1 more source

Molecular characterization of ESBL-producing Shigella sonnei isolates from patients with bacilliary dysentery in Lebanon

Journal of Infection in Developing Countries, 2009
Background: Emergence of extended-spectrum -lactamases (ESBLs) in Shigella species imparting resistance to third-generation cephalosporins is a growing concern worldwide. The aim of this study is to molecularly characterize the newly emerging beta-lactam
Ahmad H. Sabra, George F. Araj, Mireille M. Kattar, Roland Y. Abi-Rached, Marie-Therese Khairallah, John D. Glena, Ghassan M. Matar   +6 more
doaj   +1 more source

Novel determinants of antibiotic resistance : identification of mutated loci in highly methicillin-resistant subpopulations of methicillin-resistant Staphylococcus aureus [PDF]

, 2014
This work was supported by a grant from the U.S. Public Health Service 2 RO1 AI457838-14 and by grant UL1 TR000043-07S1 from the National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH) Clinical and Translational ...
Kim, Choonkeun, Hermínia de Lencastre, Matthew T. J. Holden, Holden, Matthew T J, María Pardos de la Gándara, Tomasz, Alexander, Parkhill, Julian, de Lencastre, Hermínia, Alexander Tomasz, Stephen D. Bentley, Janina Dordel, Dordel, Janina, Pardos de la Gándara, María, Chung, Marilyn, Bentley, Stephen D, Marilyn Chung, Choonkeun Kim, Julian Parkhill   +17 more
core   +1 more source

Comprehensive identification of single nucleotide polymorphisms associated with beta-lactam resistance within pneumococcal mosaic genes. [PDF]

PLoS Genetics, 2014
Traditional genetic association studies are very difficult in bacteria, as the generally limited recombination leads to large linked haplotype blocks, confounding the identification of causative variants.
Claire Chewapreecha, Pekka Marttinen, Nicholas J Croucher, Susannah J Salter, Simon R Harris, Alison E Mather, William P Hanage, David Goldblatt, Francois H Nosten, Claudia Turner, Paul Turner, Stephen D Bentley, Julian Parkhill   +12 more
doaj   +1 more source

Beta-Lactam Antibiotic Resistance Genes in the Microbiome of the Public Transport System of Quito, Ecuador

, 2023
Multidrug-resistant bacteria present resistance mechanisms against β-lactam antibiotics, such as Extended-Spectrum Beta-lactamases (ESBL) and Metallo-β-lactamases enzymes (MBLs) which are operon encoded in Gram-negative species.
Gabriela N. Tenea, Castillejo, Pablo, Hernández Alomía, Fernanda, Jarrín-V., Pablo, Molina, Alfonso, Carlos Bastidas-Caldes, Pablo Jarrín-V., Tenea, Gabriela, Fernanda Hernández-Alomía, Pablo Castillejo, C. Alfonso Molina, Bastidas Caldes, Carlos, Ballesteros Redondo, María Isabel, Isabel Ballesteros   +13 more
core   +1 more source

Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus

, 2022
Methicillin-resistant Staphylococcus aureus (MRSA) is one of the most successful human pathogens with the potential to cause significant morbidity and mortality.
Harshad Lade, Hwang-Soo Joo, Lade, Harshad, Jae-Seok Kim, Kim, Jae-Seok, Joo, Hwang-Soo   +5 more
core   +1 more source

Prevalence of Antibiotic Resistance Genes in Multidrug-Resistant Enterobacteriaceae on Portuguese Livestock Manure

Antibiotics, 2019
The exposure of both crop fields and humans to antibiotic-resistant bacteria in animal excreta is an emergent concern of the One Health initiative.
Paula Amador, Ruben Fernandes, Cristina Prudêncio, Isabel Duarte   +3 more
doaj   +1 more source

The KPC type beta-lactamases: new enzymes that confer resistance to carbapenems in Gram-negative bacilli.

Folia Histochemica et Cytobiologica, 2010
Antimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for last decades. KPC beta-lactamases hydrolyzed beta-lactams of all classes. Especially,
Piotr Wieczorek, Jadwiga Jaworowska, Alina Ostas, Paweł Sacha, Dominika Ojdana, Jerzy Ratajczak, Elzbieta Tryniszewska   +6 more
doaj   +1 more source