Efflux pump, the masked side of beta-lactam resistance in Klebsiella pneumoniae clinical isolates. [PDF]
PLoS ONE, 2009 BACKGROUND: Beta-lactamase production and porin decrease are the well-recognized mechanisms of acquired beta-lactam resistance in Klebsiella pneumoniae isolates. However, such mechanisms proved to be absent in K.
Jean-Marie Pages +6 more
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The reaction mechanism of metallo-beta-lactamases is tuned by the conformation of an active site mobile loop [PDF]
, 2018 Carbapenems are "last resort" β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria.
Alzari, Pedro M. +10 more
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Folia Histochemica et Cytobiologica, 2010 Antimicrobial resistance due to the continuous selective pressure from widespread use of antimicrobials in humans, animals and agriculture has been a growing problem for last decades. KPC beta-lactamases hydrolyzed beta-lactams of all classes. Especially,
Piotr Wieczorek +6 more
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Data in Brief, 2018 Methicillin-resistant Staphylococcus aureus (MRSA) is a rapidly emerging bacteria causing infection, which has developed resistance to most of the beta-lactam antibiotics because of newly acquired low-affinity penicillin binding protein (PBP2a), which ...
Shrikant Pawar, Xiangyu Yao, ChungDar Lu
doaj +1 more source
Antibiotics, 2023 Background: The objective was to identify associations between beta-lactam pharmacokinetic/pharmacodynamic (PK/PD) targets and Gram-negative bacteria resistance emergence in patients. Methods: Retrospective data were collected between 2016 to 2019 at the
Nicole F. Maranchick +4 more
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The Distribution of ESBL-Producing Enterobacteriaceae: Leicestershire UK Compared to Worldwide [PDF]
, 2019 open access ...
Reid, R. +2 more
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Penicillin Allergy Assessment and Skin Testing in the Outpatient Setting [PDF]
, 2019 Penicillin allergies are among of the most commonly reported allergies, yet only 10% of these patients are truly allergic. This leads to potential inadvertent negative consequences for patients and makes treatment decisions challenging for clinicians ...
Avery, Lisa M. +3 more
core +3 more sources
The effect of imipenem and diffusible signaling factors on the secretion of outer membrane vesicles and associated Ax21 proteins in Stenotrophomonas maltophilia [PDF]
, 2015 Outer membrane vesicles (OMVs) are small nanoscale structures that are secreted by bacteria and that can carry nucleic acids, proteins, and small metabolites. They can mediate intracellular communication and play a role in virulence.
Bart eDevreese +9 more
core +5 more sources
Differential DNA accessibility to polymerase enables 30-minute phenotypic β-lactam antibiotic susceptibility testing of carbapenem-resistant Enterobacteriaceae [PDF]
, 2020 The rise in carbapenem-resistant Enterobacteriaceae (CRE) infections has created a global health emergency, underlining the critical need to develop faster diagnostics to treat swiftly and correctly.
Garner, Omai B. +5 more
core +1 more source
Beta–Lactam Drug Resistance Pattern In Staphylococcus Aureus Isolates: A Review
Eurasian Journal of Science and Engineering, 2023 Methicillin Resistance Staphylococcus aureus (MRSA) is a serious human disease also considered as a chronological developing zoonotic pathogen of common health and in term of veterinary concern.
Kovan Dilawer Issa +1 more
doaj +1 more source