Results 1 to 10 of about 52,329 (268)
Breakthrough Advances in Beta-Lactamase Inhibitors: New Synthesized Compounds and Mechanisms of Action Against Drug-Resistant Bacteria. [PDF]
Pharmaceuticals (Basel)Beta-lactam drugs hold a central place in the antibacterial arsenal, and the production of beta-lactamases by drug-resistant bacteria has severely compromised the effectiveness of nearly all available beta-lactams.
Huang YS, Zhou H.
europepmc +2 more sources
Beta-lactamase of R factors [PDF]
Journal of Bacteriology, 1968 Jr . Doyle J. Evans +3 more
openalex +4 more sources
Innovative approaches in phenotypic beta-lactamase detection for personalised infection management. [PDF]
Nat CommunBeta-lactamase-producing Enterobacteriaceae present a significant therapeutic challenge. Current developments in phenotypic diagnostics focus primarily on rapid minimum inhibitory concentration (MIC) determination.
Lawrence J +5 more
europepmc +2 more sources
Design, synthesis, and evaluation the anti-β-lactamase activity of new sulphathiazole-derived monobactam compounds [PDF]
المجلة العراقية للصيدلة, 2020 Objectives: β-Lactams are the most successful antibiotics for the management of infectious diseases. Unfortunately, the bacterial production of β-lactamase that hydrolyzes the β-lactam ring can inactivate these drugs.
Ahmed Mahmood +2 more
doaj +1 more source
Jornal Brasileiro de Patologia e Medicina Laboratorial, 2006 Nos ultimos anos tem sido observada maior incidencia de bacilos Gram-negativos resistentes a cefalosporinas de espectro ampliado no ambiente hospitalar, ocasionando, assim, maior uso de betalactâmicos mais potentes, como os carbapenens. A utilizacao de carbapenens exerce maior pressao seletiva sobre a microbiota hospitalar, o que pode ocasionar aumento
Mendes, Rodrigo Elisandro +3 more
openaire +3 more sources
Journal of Nepal Medical Association, 2022 Introduction: Ampicillinase C beta-lactamase-producing organisms are often resistant to multiple antimicrobial agents, and therapeutic options against these pathogens are limited. Limited information is available regarding Ampicillinase C beta-lactamase
Shusila Khadka +4 more
doaj +1 more source
Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases [PDF]
Antimicrobial Agents and Chemotherapy, 1995 The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5.
Toshinobu Horii +4 more
openaire +2 more sources
Journal of Nepal Medical Association, 2015 Introduction: The increasing reports on extended-spectrum-beta-lactamase and metallo-betalactamase producing Escherichia coli have addressed a potential threat to global health since it is found to be highly resistance to most of the currently available ...
Basudha Shrestha +9 more
doaj +3 more sources
An Overview of Extended Spectrum Beta Lactamases and Metallo Beta Lactamases
Advances in Microbiology, 2021 Antibiotic resistant β-lactamases are diverse and complex enzymes produced by most of the Gram-negative bacteria that are mediated by number of plasmids. The impact of these enzymes has posed a major threat to the health sectors and has challenged the available treatment options for both community and hospital acquired infections.
N. G. Manjula +4 more
openaire +3 more sources