Results 21 to 30 of about 1,103,793 (328)

The reaction mechanism of metallo-beta-lactamases is tuned by the conformation of an active site mobile loop [PDF]

, 2018
Carbapenems are "last resort" β-lactam antibiotics used to treat serious and life-threatening health care-associated infections caused by multidrug-resistant Gram-negative bacteria.
Alzari, Pedro M., Bethel, Christopher R., Bonomo, Robert A., Giannini, Estefanía, Klinke, Sebastian, Llarrull, Leticia Irene, Mojica, María F., Otero, Lisandro Horacio, Palacios, Antonela Rocio, Taracila, Magdalena A., Vila, Alejandro Jose   +10 more
core   +1 more source

Beta-lactamase antimicrobial resistance in Klebsiella and Enterobacter species isolated from healthy and diarrheic dogs in Andhra Pradesh, India [PDF]

Veterinary World, 2017
Aim: The aim of this study was to characterize beta-lactamase antimicrobial resistance in Klebsiella and Enterobacter species isolated from healthy and diarrheic dogs in Andhra Pradesh. Materials and Methods: A total of 136 rectal swabs were collected
N. Mohammad Sharif, B. Sreedevi, R. K. Chaitanya, D. Sreenivasulu   +3 more
doaj   +1 more source

Amoxicillin concentrations in relation to beta-lactamase activity in sputum during exacerbations of chronic obstructive pulmonary disease [PDF]

, 2015
Background: Acute exacerbations of chronic obstructive pulmonary disease (COPD) are often treated with antibiotics. Theoretically, to be maximally effective, the antibiotic concentration at sites of infection should exceed the minimum inhibitory ...
Brusse-Keizer, Marjolein, Hendrix, Ron, Movig, Kris, Nijdam, Lars, Palen, Job van der, Valk, Paul van der, Zanden, Rogier W. van der   +6 more
core   +3 more sources

Beta-lactamase database (BLDB) – structure and function

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Beta-Lactamase Database (BLDB) is a comprehensive, manually curated public resource providing up-to-date structural and functional information focused on this superfamily of enzymes with a great impact on antibiotic resistance.
T. Naas, S. Oueslati, R. Bonnin, Marie Dabos, A. Zavala, L. Dortet, P. Retailleau, B. Iorga   +7 more
semanticscholar   +1 more source

Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1 [PDF]

bioRxiv, 2015
The quantitative characterization of mutational landscapes is a task of outstanding importance in evolutionary and medical biology: It is, e.g., of central importance for our understanding of the phenotypic effect of mutations related to disease and ...
M. Figliuzzi, H. Jacquier, A. Schug, O. Tenaillon, M. Weigt   +4 more
semanticscholar   +1 more source

Allergic Reactions and Cross-Reactivity Potential with Beta-Lactamase Inhibitors

Pharmacy, 2019
Although beta-lactam allergies are an emerging focus of stewardship programs and interventions, less is publicly released regarding allergies to beta-lactamase inhibitors. This review presents and evaluates the data regarding allergic reactions with beta-
Kayla R. Stover, Katie E. Barber, Jamie L. Wagner   +2 more
doaj   +1 more source

Assessing the occurrence and transfer dynamics of ESBL/pAmpC-producing Escherichia coli across the broiler production pyramid [PDF]

, 2019
Extended-spectrum \u3b2-lactamase (ESBL)- and plasmid mediated AmpC-type cephalosporinase (pAmpC)-producing Escherichia coli (ESBL/pAmpC E. coli) in food-producing animals is a major public health concern.
APOSTOLAKOS, ILIAS, Fasolato, L., MUGHINI GRAS, LAPO, Piccirillo, A.   +3 more
core   +1 more source

In Silico Assigned Resistance Genes Confer Bifidobacterium with Partial Resistance to Aminoglycosides but Not to Β-Lactams [PDF]

, 2013
peer-reviewedBifidobacteria have received significant attention due to their contribution to human gut health and the use of specific strains as probiotics.
Cotter, Paul D., Fitzgerald, Gerald F, Fouhy, Fiona, O'Connell-Motherway, Mary, Ross, R Paul, STANTON, CATHERINE, van Sinderen, Douwe   +6 more
core   +7 more sources

Massive Increase, Spread, and Exchange of Extended Spectrum {beta}-Lactamase-Encoding Genes Among Intestinal Enterobacteriaceae in Hospitalized Children With Severe Acute Malnutrition in Niger. [PDF]

, 2011
Background. From the time of CTX-M emergence, extended-spectrum β-lactamase-producing enterobacteria (ESBL-E) have spread worldwide in community settings as well as in hospitals, particularly in developing countries.
Andremont, A, Angebault, C, Armand-Lefèvre, L, Barbier, F, de Rekeneire, N, El Mniai, A, Hugede, H-C, Jacquier, H, Janssens, A-C, Page, A-L, Raskine, L, Ruppé, E, Sayadi, S, Woerther, P-L   +13 more
core   +2 more sources

Effect of pH on activities of novel beta-lactamases and beta-lactamase inhibitors against these beta-lactamases [PDF]

Antimicrobial Agents and Chemotherapy, 1995
The effects of acidic conditions on activities of seven beta-lactamases--TEM-1 (class A), KOXY (class A), IMP-1 (class B), AmpC (class C), MOX-1 (class C), OXA-5 (class D), and PSE-2 (class D)--and their inhibitors were measured. The enzymatic activities of KOXY, IMP-1, and MOX-1 at pH 5.8 were slightly lower than those at pH 7.5.
S, Ohsuka, Y, Arakawa, T, Horii, H, Ito, M, Ohta   +4 more
openaire   +2 more sources