Results 111 to 120 of about 153,260 (300)

Smart Biomaterials and Dressings for the Treatment of Chronic Inflammatory Skin Diseases

Rare Metals, EarlyView.
ABSTRACT Chronic inflammatory skin diseases, encompassing immune‐inflammatory conditions and infection‐associated dermatoses, pose significant clinical challenges due to high prevalence, recurrence, and therapeutic resistance, affect over 30% of the global population.
Zehao Lan, Shengjie Xue, Junyi Yin, Shaolei Wang, Yunlei Zhou, Jieyue Liao   +5 more
wiley   +1 more source

Transforming Fragile Hydrogel Chips Into Standardized Cartridges via Contact Line Pinning for Robust Microfluidics

Small, EarlyView.
Hydrogel‐based microfluidic chips revolutionize drug delivery, tissue engineering, and biosensing, yet face challenges due to fragility and connection difficulty. This study introduces a novel cartridge design that enhances usability through a hydrogel–plastic hybrid design and a contactless connection method.
Sin‐Yung Siu, Chiu‐Wing Chan, Yisu Wang, Langcheng Feng, Yichen Su, Yin Chen, Christopher K C LAI, Pingan Zhu, Kangning Ren   +8 more
wiley   +1 more source

Imipenem resistance in clinical Escherichia coli from Qom, Iran [PDF]

, 2018
OBJECTIVE: The emergence of metallo-\u3b2-lactamase-producing Enterobacteriaceae is a worldwide health concern. In this study, the first evaluation of MBL genes, bla IMP and bla VIM , in Escherichia coli resistant to imipenem isolated from urine and ...
Esmkhani, M., Hashemi, A., Kermani, S., Piccirillo, A., Shams, E., Shams, S.   +5 more
core   +1 more source

Nanomedicine Meets Immunotherapy: Transforming Chimeric Antigen Receptor T Cell Treatment for Solid Tumors

Small Science, EarlyView.
This review highlights recent advances in nanomedicine that enhance chimeric antigen receptor (CAR) T cell therapy against solid tumors. It discusses key barriers to CAR T cell efficacy and outlines nanotechnology‐based strategies to improve tumor targeting, remodel the immunosuppressive microenvironment, and integrate nanomaterials into CAR T cell ...
Stephen O’Rourke, Nuo Xu, Hongjun Wang, Hexin Chen   +3 more
wiley   +1 more source

The role of bacterial secretion systems in the virulence of Gram-negative airway pathogens associated with cystic fibrosis [PDF]

, 2016
Cystic fibrosis (CF) is the most common lethal inherited disorder in Caucasians. It is caused by mutation of the CF transmembrane conductance regulator (CFTR) gene.
Depluverez, Sofie, Devos, Simon, Devreese, Bart   +2 more
core   +2 more sources

A structured, behavioural science approach to the preparation of antimicrobial stewardship interventions for companion animal veterinarians

Veterinary Record, EarlyView.
Abstract Background A structured, behavioural science approach was adopted to develop antimicrobial stewardship interventions in UK first‐opinion companion animal veterinary practice. The objectives were to identify behavioural targets for intervention and to understand how practice contexts influence these behaviours.
Ben Walker, Dan O'Neill, Huw Stacey, Dave Brodbelt   +3 more
wiley   +1 more source

Intestinal colonization due to Escherichia coli ST131: Risk factors and prevalence [PDF]

, 2018
Background Escherichia coli sequence type 131 (ST131) is a successful clonal group that has dramatically spread during the last decades and is considered an important driver for the rapid increase of quinolone resistance in E. coli.
A Talaminos, E Torres, JH Han, JR Johnson, L López-Cerero, L López-Cerero, M-H Nicolas-Chanoine, MJ Burgess, P Huizinga, R Banerjee, V Leflon-Guibout   +10 more
core   +1 more source

The depletion of serine beta‐lactamase‐like protein (LACTB) ameliorates metabolic dysfunction–associated steatotic liver disease by reducing ubiquitin‐mediated degradation of carnitine palmitoyltransferase 2

Diabetes, Obesity and Metabolism, EarlyView.
Abstract Aims Metabolic dysfunction–associated steatotic liver disease (MASLD) represents one of the most common chronic liver disorders worldwide, and its incidence continues to rise each year. Serine β‐lactamase‐like protein (LACTB) is a serine protease that plays a crucial role in lipid metabolism and hepatocellular carcinoma, but its function in ...
Wujiang Shi, Xin Liu, Nan Wang, Qianwen Zhang, Jianjun Gao, Canghai Guan, Yapeng Li, Chengru Yang, Shaowu Bi, Xinlei Zou, Xiangyu Zhong   +10 more
wiley   +1 more source

Sulbactam-containing β-lactamase inhibitor combinations [PDF]

Clinical Microbiology and Infection, 2008
Sulbactam irreversibly inhibits the hydrolytic activity of beta-lactamases. This compound is commercially available in combination with either ampicillin or cefoperazone. In each instance, the activity of the partner antibiotic against beta-lactamase-producing bacteria is restored.
openaire   +3 more sources

European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) 2025 guidelines for surgical antimicrobial prophylaxis in dogs and cats

Journal of Small Animal Practice, EarlyView.
Surgical antimicrobial prophylaxis involves the administration of antimicrobials to reduce the risk of a surgical site infection and represents a significant proportion of all antimicrobial use in cats and dogs. This evidence‐based, European Network for Optimization of Veterinary Antimicrobial Therapy guideline provides recommendations for both peri ...
F. Allerton, T. M. Sørensen, K. Scahill, J. E. Ruperez, F. Swinbourne, D. R. Verwilghen, M. C. Nolff, F. Foroutan, S. J. Baines, A. Vilen, L. Pelligand, E. M. Broens, P. L. Toutain, M. L. Brennan, T. Mooney, S. Clarke, J. E. Miles, J. L. Granick, Y. Winsborg, L. R. Jessen, J. S. Weese, on behalf of the European Network for Optimization of Veterinary Antimicrobial Therapy (ENOVAT) guidelines and the ESCMID Study Group for Veterinary Microbiology (ESGVM)   +21 more
wiley   +1 more source