Results 21 to 30 of about 153,260 (300)

Pharmacokinetic/pharmacodynamic target attainment in critically ill renal patients on antimicrobial usage: focus on novel beta-lactams and beta lactams/beta-lactamase inhibitors

Expert Review of Clinical Pharmacology, 2021
Introduction Several novel beta-lactams (BLs) and/or beta lactams/beta-lactamase inhibitors (BL/BLIs) have been recently developed for the management of multidrug-resistant bacterial infections.
Milo Gatti, F. Pea
semanticscholar   +1 more source

Naturally-occurring .BETA.-lactamase inhibitors with antibacterial activity.

Journal of antibiotics (Tokyo. 1968), 1976
A. G. BROWN, Douglas Butterworth, Martin Cole, G. Hanscomb, John Hood, Christopher Reading, G. N. Rolinson   +6 more
openalex   +3 more sources

Antibiotic use in Australian and Swedish primary care: a cross-country comparison

Scandinavian Journal of Primary Health Care, 2022
Objective Antimicrobial resistance is a growing worldwide problem and is considered to be one of the biggest threats to global health by the World Health Organization.
Konny Andersson, Mieke van Driel, Katarina Hedin, Samantha Hollingworth, Gregory Merlo   +4 more
doaj   +1 more source

Clinical Outcomes of Non-carbapenem Treatment for Urinary Tract Infections Caused by Extended-spectrum β-lactamase-producing [PDF]

Childhood Kidney Diseases, 2021
Purpose The purpose of this study was to investigate the clinical outcomes of non-carbapenem treatment for urinary tract infections (UTIs) caused by extended-spectrum β-lactamase (ESBL)-producing Escherichia coli (E. coli) in young children.
Eunae Kim, Yo Han Ahn, Jung Won Lee, Eujin Park   +3 more
doaj   +1 more source

Treatment in Infections by Enterobacterales Producing Extended Spectrum Betalactamase. Systematic Review

Kasmera, 2021
Extended spectrum beta-lactamases producing Enterobacterales have become pandemic worldwide representing a major public health threat due to poor outcomes and high mortality associated with infections by these bacteria, consequently it is essential to ...
Carli Samira Aziz Delgado, José Andrés Mendoza Gaviria   +1 more
doaj   +1 more source

Discovery of beta-lactamase CMY-10 inhibitors for combination therapy against multi-drug resistant Enterobacteriaceae

PLoS ONE, 2021
β-lactam antibiotics are the most widely used antimicrobial agents since the discovery of benzylpenicillin in the 1920s. Unfortunately, these life-saving antibiotics are vulnerable to inactivation by continuously evolving β-lactamase enzymes that are ...
Nousheen Parvaiz, Faisal Ahmad, Wenbo Yu, Alexander D. MacKerell, S. S. Azam   +4 more
semanticscholar   +1 more source

Functional Dynamics of Substrate Recognition in TEM Beta-Lactamase

Entropy, 2022
The beta-lactamase enzyme provides effective resistance to beta-lactam antibiotics due to substrate recognition controlled by point mutations. Recently, extended-spectrum and inhibitor-resistant mutants have become a global health problem.
Chris Avery, Lonnie Baker, Donald J. Jacobs   +2 more
doaj   +1 more source

Neutralizing Carbapenem Resistance by Co-Administering Meropenem with Novel β-Lactam-Metallo-β-Lactamase Inhibitors

Antibiotics, 2023
Virulent Enterobacterale strains expressing serine and metallo-β-lactamases (MBL) genes have emerged responsible for conferring resistance to hard-to-treat infectious diseases. One strategy that exists is to develop β-lactamase inhibitors to counter this
Nakita Reddy, Letisha Girdhari, Mbongeni Shungube, Arnoldus C. Gouws, Byron K. Peters, Kamal K. Rajbongshi, Sooraj Baijnath, Sipho Mdanda, Thandokuhle Ntombela, Thilona Arumugam, Linda A. Bester, Sanil D. Singh, Anil Chuturgoon, Per I. Arvidsson, Glenn E. M Maguire, Hendrik G. Kruger, Thavendran Govender, Tricia Naicker   +17 more
doaj   +1 more source

Variations in the SDN Loop of Class A Beta-Lactamases: A Study of the Molecular Mechanism of BlaC (Mycobacterium tuberculosis) to Alter the Stability and Catalytic Activity Towards Antibiotic Resistance of MBIs

Frontiers in Microbiology, 2021
The emergence of multidrug-resistant (MDR) and extensively drug-resistant (XDR) tuberculosis calls for an immediate search for novel treatment strategies.
Sourya Bhattacharya, Vivek Junghare, Niteesh Kumar Pandey, Subhecchha Baidya, Harsha Agarwal, Neeladrisingha Das, Ayan Banerjee, Ayan Banerjee, Debashish Ghosh, Debashish Ghosh, Partha Roy, Hirak K. Patra, Saugata Hazra, Saugata Hazra   +13 more
doaj   +1 more source

Efficacy of β‐lactam/β‐lactamase inhibitors to treat extended‐spectrum beta‐lactamase‐producing Enterobacterales bacteremia secondary to urinary tract infection in kidney transplant recipients (INCREMENT‐SOT Project)

Transplant Infectious Disease, 2020
Whether active therapy with β‐lactam/β‐lactamase inhibitors (BLBLI) is as affective as carbapenems for extended‐spectrum β‐lactamase‐producing Enterobacterales (ESBL‐E) bloodstream infection (BSI) secondary to urinary tract infection (UTI) in kidney ...
L. Pierrotti, E. Pérez-Nadales, M. Fernández-Ruiz, B. Gutiérrez-Gutiérrez, Ban Hock Tan, J. Carratalá, I. Oriol, M. Paul, Noa Cohen-Sinai, F. López‐Medrano, R. San-Juan, M. Montejo, M. Freire, E. Cordero, M. David, E. Merino, Seema Mehta Steinke, P. Grossi, Á. Cano, E. Seminari, M. Valerio, F. Gunseren, M. Rana, A. Mularoni, P. Martín-Dávila, C. van Delden, Melie Hamiyet Demirkaya, Zeliha Koçak Tufan, Belén Loeches, R. Iyer, F. Soldani, B. Eriksson, B. Pilmis, M. Rizzi, J. Coussement, W. Clemente, E. Roilides, Á. Pascual, L. Martínez-Martínez, J. Rodríguez-Baño, J. Torre-Cisneros, J. Aguado   +41 more
semanticscholar   +1 more source