Results 51 to 60 of about 153,260 (300)

Successful Treatment of Acute Prostatitis Caused by Multidrug-Resistant Escherichia coli With Tigecycline Monotherapy [PDF]

, 2020
We present a successful treatment, with tigecycline monotherapy, of acute prostatitis caused by multidrug-resistant Escherichia coli harboring an NDM-1 carbapemenase along with a CMY-2 cephalosporinase and a TEM ...
Babouee Flury, Baharak, Buetti, Niccolo, Casanova, Carlo, Furrer, Hansjakob, Jent, Philipp, Livermore, David M, Lo Priore, Elia, Pelzer, Niklas   +7 more
core   +2 more sources

Inhibitor resistant class A beta-lactamases [PDF]

Frontiers in Bioscience, 1999
Beta-lactamase inhibitors (clavulanic acid, tazobactam, and sulbactam) greatly enhance the therapeutic efficacy of their partner antibiotics (amoxacillin, ampicillin, piperacillin, and ticarcillin) against common enteric and non-enteric organisms possessing class A beta-lactamases.
R A, Bonomo, L B, Rice
openaire   +2 more sources

Multiparametric determination of genes and their point mutations for identification of beta-lactamases [PDF]

, 2010
More than half of all currently used antibiotics belong to the beta-lactam group, but their clinical effectiveness is severely limited by antibiotic resistance of microorganisms that are the causative agents of infectious diseases. Several mechanisms for
A. A. Medeiros, A. Bauernfield, A. J. Brookes, A. M. Egorov, A. Nikulin, A. Philippon, A. Tamilselvi, A. Yu. Rubina, B. E. E. Cleven, B. Strommenger, C. C. Randegger, C. D. Steward, C. Heritier, C. Heritier, C. I. Birkett, C. Mabilat, C. Mugnaioli, D. E. Mudrak, D. Gryadunov, D. L. Paterson, D. L. Paterson, D. L. Paterson, D. M. Leinberger, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. M. Livermore, D. Szabo, D. V. Ivanov, E. B. Chaibi, E. M. Southern, F. Hayes, F. J. L. Robberts, F. Perez, F.-H. M’Zali, G. F. Weldhagen, H. C. Maltezou, H. F. Chambers, H. J. Monstein, H. Knothe, H. Wang, I. Massova, I. Rodriguez, I. Weigand, I. Wiegand, J. D. D. Pitout, J. D. D. Pitout, J. D. Pitout, J. D. Pitout, J. Empel, J. F. Petrosino, J. L. Jones, J. M. Ghuysen, J. Rodriguez-Bano, J. Schlesinger, J. Schmitt, J. W. Schumm, K. Bush, K. Bush, K. Bush, L. Bodrossy, L. Drieux, L. N. Ikryannikova, L. Pagani, L. Poirel, L. Poirel, L. S. Tzouvelekis, L. X. Zhu, L. Xu, L. Xu, M. Babic, M. Batchelor, M. Cassone, M. Chee, M. Edelstein, M. F. Lartigue, M. Guckenberger, M. H. Richmond, M. I. Page, M. J. Heller, M. J. Schwaber, M. J. Schwaber, M. M. Ulyashova, M. M. Ulyashova, M. Nukaga, M. Ozsoz, M. Quinteros, M. R. Mulvey, M. Schena, M. Shogo, M. Yu. Rubtsova, N. C. Strynadka, N. Datta, N. Shibata, N. Woodford, N. Woodford, P. A. James, P. Bradford, P. C. Fleming, P. M. Hawkey, R. Alonso, R. B. Sykes, R. Bonnet, R. Bonnet, R. Canton, R. D. Schmid, R. P. Ambler, S. Chen, S. Egorova, S. Harada, S. K. Du Bois, S. Kalai Blagui, S. V. Sidorenko, S. V. Sidorenko, T. L. Wu, T. Naas, T. R. Hughes, T. T. Bachmann, V. A. Doss, V. Chizhikov, V. Grimm, V. M. Ensor, V. Perreten, X. Cao, X. Yu, Y. Lee, Y. Michikawa   +127 more
core   +1 more source

In vitro activity of ceftazidime/avibactam against carbapenem-nonsusceptible Klebsiella penumoniae isolates collected during the first wave of the SARS-CoV-2 pandemic: a Southern Italy, multicenter, surveillance study

Journal of Global Antimicrobial Resistance, 2022
Objectives: Carbapenemase-producing Enterobacterales (CPE) represent a serious threat for human health being frequently resistant to most of available antibiotics classes.
Gianfranco La Bella, Teresa Lopizzo, Laura Lupo, Rosa Angarano, Anna Curci, Barbara Manti, Giovanna La Salandra, Adriana Mosca, Rosella De Nittis, Fabio Arena   +9 more
doaj   +1 more source

Inhibiting the β-Lactamase of Mycobacterium tuberculosis (Mtb) with Novel Boronic Acid Transition-State Inhibitors (BATSIs) [PDF]

, 2015
BlaC, the single chromosomally-encoded β-lactamase of Mycobacterium tuberculosis, has been identified as a promising target for novel therapies that rely upon β-lactamase inhibition.
Bethel, Christopher R., Blanchard, John S., Bonomo, Robert A., CASELLI, Emilia, Hazra, Saugata, Kurz, Sebastian G., PRATI, Fabio, ROMAGNOLI, Chiara   +7 more
core   +1 more source

Piperacillin–tazobactam as alternative to carbapenems for ICU patients

Annals of Intensive Care, 2017
Several studies suggest that alternatives to carbapenems, and particulary beta-lactam/beta-lactamase inhibitor combinations, can be used for therapy of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-PE)-related infections in non-ICU ...
Benoit Pilmis, Vincent Jullien, Alexis Tabah, Jean-Ralph Zahar, Christian Brun-Buisson   +4 more
doaj   +1 more source

Exploiting the aggregation propensity of beta-lactamases to design inhibitors that induce enzyme misfolding

Nature Communications, 2023
There is an arms race between beta-lactam antibiotics development and co-evolving beta-lactamases, which provide resistance by breaking down beta-lactam rings.
Ladan Khodaparast, Laleh Khodaparast, Guiqin Wu, Emiel Michiels, Rodrigo Gallardo, Bert Houben, Teresa Garcia, Matthias De Vleeschouwer, Meine Ramakers, Hannah Wilkinson, Ramon Duran-Romaña, Johan Van Eldere, Frederic Rousseau, Joost Schymkowitz   +13 more
doaj   +1 more source

Klebsiella pneumoniae Susceptibility to Carbapenem/Relebactam Combinations: Influence of Inoculum Density and Carbapenem-to-Inhibitor Concentration Ratio

Biomedicines, 2022
The inoculum effect (IE) is a well-known phenomenon with beta-lactams. At the same time, the IE has not been extensively studied with carbapenem/carbapenemase inhibitor combinations.
Maria V. Golikova, Kamilla N. Alieva, Alla V. Filimonova, Vladimir A. Ageevets, Ofeliia S. Sulian, Alisa A. Avdeeva, Sergey V. Sidorenko, Stephen H. Zinner   +7 more
doaj   +1 more source

Evolution of Drug Resistance: Insight on TEM β-Lactamases Structure and Activity and β-Lactam Antibiotics [PDF]

, 2014
Since the discovery of the first penicillin bacterial resistance to β-lactam antibiotics has spread and evolved promoting new resistances to pathogens.
Fernandes, Rúben, Moreira, I. S., Pimenta, A. C.   +2 more
core   +1 more source

Beta-Lactamase Repressor BlaI Modulates Staphylococcus aureus Cathelicidin Antimicrobial Peptide Resistance and Virulence. [PDF]

, 2015
BlaI is a repressor of BlaZ, the beta-lactamase responsible for penicillin resistance in Staphylococcus aureus. Through screening a transposon library in S.
Gallo, Richard L, Haste, Nina M, Kristian, Sascha A, Meharena, Hiruy S, Nizet, Victor, Olson, Joshua, Pence, Morgan A   +6 more
core   +3 more sources