Results 81 to 90 of about 153,260 (300)

Bottom‐up Strategies for Generating Polymer Protocells That Mimic Cellular Communication

Chemistry – A European Journal, EarlyView.
This review focuses on polymeric protocells produced using a bottom‐up approach. Polymer‐based assemblies guarantee stability and designability by adjusting the properties of the amphiphilic copolymers used. The review covers protocell architectures, production, and their intra‐ and intercellular communication mechanisms.
Gloria Saorin, Xinan Huang, Voichita Mihali, Cornelia G. Palivan   +3 more
wiley   +1 more source

Targeting Class A and C Serine \u3b2-Lactamases with a Broad-Spectrum Boronic Acid Derivative [PDF]

, 2014
Production of \u3b2-lactamases (BLs) is the most widespread resistance mechanism adopted by bacteria to fight \u3b2-lactam antibiotics. The substrate spectrum of BLs has become increasingly broad, posing a serious health problem. Thus, there is an urgent
Alberto Venturelli, Bebrone C., Bennett P. M., Blizzard T. A., Bonnefoy A., Bonnet R., Bradshaw J. M., Brian K. Shoichet, Brunger A. T., Bush K., Bush K., Carter P. J., Cecilia Pozzi, Chaibi E. B., Chen Y., Chen Y., Coleman K., Delmas J., Donatella Tondi, Drawz S. M., Ehmann D. E., Emsley P., Farina D., Hirsch E. B., Hunter C. A., Ibuka A., Jacoby G. A., Kettner C. A., Laskowski R. A., Lovell S. C., Majumdar S., Marciano D. C., Maria Paola Costi, Morandi F., Murshudov G. N., Ness S., Nichols D. A., Otwinowski Z. M., Pages J. M., Potterton E., Powers R. A., Powers R. A., Richard Bonnet, Robin F., Roth T. A., Strynadka N. C., Strynadka N. C. J., Strynadka N. C. J., Thornton J. M., Tondi D., Tondi D., Usher K., Venturelli A., Waley S. G., Wang X., Wang X., Wang X., Willcockson I. U., Winn M. D.   +58 more
core   +3 more sources

614. Pharmacodynamics (PD) of the Beta-Lactamase Inhibitor Xeruborbactam When Administered as the Oral Prodrug in Combination with Ceftibuten [PDF]

, 2022
Ziad Tarazi, Niki Roos, Ted Page, David Griffith   +3 more
openalex   +1 more source

Biomarkers of Drug‐Induced Kidney Injury: Use in Clinical Trials and Recent Examples of Impact on Drug Development

Clinical Pharmacology &Therapeutics, EarlyView.
This manuscript describes the scope of implementation and impact of a regulatory agency‐qualified panel of six urine biomarkers on drug development, the process for which was conducted and funded by the Critical Path Institute, the Foundation for the National Institutes of Health, and the United States Food and Drug Administration.
Tanja S. Zabka, Michael Lawton, Tom Chu, Gary S. Friedman, Katrina Peron, Stefan R. Sultana, Warren E. Glaab, Nicholas M. P. King   +7 more
wiley   +1 more source

Rare Plasmid-Mediated AmpC Beta-Lactamase DHA-1 Located on Easy Mobilized IS26-Related Genetic Element Detected in Escherichia coli from Livestock and Food in Germany

Microorganisms
AmpC beta-lactamases cause resistance to third-generation cephalosporins, including beta-lactamase inhibitors. In Escherichia coli from the German food production chain, the majority of AmpC beta-lactamase activity can be attributed to plasmid-mediated ...
Chiara Manfreda, Annemarie Kaesbohrer, Silvia Schmoger, Tanja Skladnikiewicz-Ziemer, Mirjam Grobbel, Alexandra Irrgang   +5 more
doaj   +1 more source

Treatment Modalities and Antimicrobial Stewardship Initiatives in the Management of Intra-Abdominal Infections

Antibiotics, 2016
Antimicrobial stewardship programs (ASPs) focus on improving the utilization of broad spectrum antibiotics to decrease the incidence of multidrug-resistant Gram positive and Gram negative pathogens.
Charles Hoffmann, Matthew Zak, Lisa Avery, Jack Brown   +3 more
doaj   +1 more source

Biofilm is a major virulence determinant in bacterial colonization of chronic skin ulcers independently from the multidrug resistant phenotype [PDF]

, 2017
Bacterial biofilm is a major factor in delayed wound healing and high levels of biofilm production have been repeatedly described in multidrug resistant organisms (MDROs).
Bordignon, Valentina, Cavallo, Ilaria, Cilli, Laura, De Santis, Alessandra, Di Domenico, Enea Gino, Di Salvo, Fabiola, Ensoli, Fabrizio, Farulla, Ilaria, Gallo, Maria Teresa, La Parola, Ilaria Lesnoni, Pimpinelli, Fulvia, Pontone, Martina, Prignano, Grazia, Sperduti, Isabella, Toma, Luigi, Vespaziani, Matteo   +15 more
core   +2 more sources

Efficacy and safety of broad spectrum penicillins with or without beta-lactamase inhibitors versus 1st and 2nd generation cephalosporins as prophylactic antibiotics at cesarean section: a systematic review and meta-analysis [PDF]

, 2022
Qianqian Song, Jingjing Yan, Na Bu, Weidong Fei   +3 more
openalex   +1 more source

Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 IWGT quantitative analysis expert working group meeting

Environmental and Molecular Mutagenesis, EarlyView.
Abstract Quantitative risk assessments of chemicals are routinely performed using in vivo data from rodents; however, there is growing recognition that non‐animal approaches can be human‐relevant alternatives. There is an urgent need to build confidence in non‐animal alternatives given the international support to reduce the use of animals in toxicity ...
Marc A. Beal, Guangchao Chen, Kerry L. Dearfield, Min Gi, Bhaskar Gollapudi, Robert H. Heflich, Katsuyoshi Horibata, Alexandra S. Long, David P. Lovell, Barbara L. Parsons, Stefan Pfuhler, John Wills, Andreas Zeller, George Johnson, Paul A. White   +14 more
wiley   +1 more source

Previous antibiotic exposure increases risk of infection with extended-spectrum-β-lactamase- and AmpC-producing Escherichia coli and Klebsiella pneumoniae in pediatric patients [PDF]

, 2016
The objective of this study was to determine whether antibiotic exposure is associated with extended-spectrum-beta-lactamase- or AmpC-producing Escherichia coli or Klebsiella pneumoniae infections in children.
Adler, Amanda L, Elward, Alexis, Haaland, Wren, Kronman, Matthew P, Miles-Jay, Arianna, Newland, Jason G, Qin, Xuan, Wessman, Scott J, Zaoutis, Theoklis, Zerr, Danielle M, Zhou, Chuan   +10 more
core   +2 more sources