Results 101 to 110 of about 27,905 (224)

Una revisión de los avances en la terapéutica de la enfermedad de Alzheimer: estrategia frente a la proteína β-amiloide

Neurología, 2018
Resumen: Introducción: La enfermedad de Alzheimer (EA) es el principal trastorno neurodegenerativo que provoca una discapacidad intelectual total en los pacientes que la presentan.
J. Folch, M. Ettcheto, D. Petrov, S. Abad, I. Pedrós, M. Marin, J. Olloquequi, A. Camins   +7 more
doaj   +1 more source

A novel long non-coding natural antisense RNA is a negative regulator of Nos1 gene expression [PDF]

, 2015
Long non-coding natural antisense transcripts (NATs) are widespread in eukaryotic species. Although recent studies indicate that long NATs are engaged in the regulation of gene expression, the precise functional roles of the vast majority of them are ...
AC Thénié, B Holmqvist, B Kuzin, B Moreno-Lopez, BL Sopher, C-H Cheng, D Dahary, DS Bredt, E Ciani, E Pavesi, GB Robb, J Chen, J Garthwaite, J-T Li, JB Kelley, JE Fish, JH Brann, K Matsui, KY Kwan, L Zhou, MA Faghihi, MA Packer, ME Evangelopoulos, ME Evangelopoulos, MHT Ling, N Peunova, P Ogilvie, RG Tremblay, S Hindley, S Korneev, SA Korneev, SA Korneev, SA Korneev, SA Korneev, SM Gibbs, SR Vincent, U Forstermann, V Calabrese, Y Zhang   +38 more
core   +1 more source

Targeted Therapy and Immunotherapies in Hepatocellular Carcinoma: Mechanisms and Clinical Studies

MedComm, Volume 7, Issue 5, May 2026.
The mechanism of multiple signaling pathways and their related targeted inhibitors in HCC. (A) The mechanism of Ras/Raf/MEK/ERK signaling pathway and its related targeted inhibitors; (B) the mechanism of PI3K/AKT/mTOR signaling pathway and its crosstalk with other pathways and its related targeted inhibitors; (C) the mechanism of JAK/STAT signaling ...
Penghui He, Sinan Xie, Kunlin Xie, Fengwei Gao, Yunshi Cai, Yan Huang, Chang Liu, Hong Wu, Yinghao Lyu, Tian Lan   +9 more
wiley   +1 more source

Review of the advances in treatment for Alzheimer disease: strategies for combating β-amyloid protein

Neurología (English Edition), 2018
Introduction: Alzheimer disease (AD) is a major neurodegenerative disorder which eventually results in total intellectual disability. The high global prevalence and the socioeconomic burden associated with the disease pose major challenges for public ...
J. Folch, M. Ettcheto, D. Petrov, S. Abad, I. Pedrós, M. Marin, J. Olloquequi, A. Camins   +7 more
doaj   +1 more source

Destruxin E Decreases Beta-Amyloid Generation by Reducing Colocalization of Beta-Amyloid-Cleaving Enzyme 1 and Beta-Amyloid Protein Precursor [PDF]

, 2009
Alzheimer-disease-associated beta-amyloid (A beta) is produced by sequential endoproteolysis of beta-amyloid protein precursor (beta APP): the extracellular portion is shed by cleavage in the juxtamembrane region by beta-amyloid-cleaving enzyme (BACE ...
Dohi, Keiji, Fukumori, Akio, Haass, Christian, Hasegawa, Hiroshi, Hosono, Motoko, Itoh, Naohiro, Jiang, Jingwei, Kato, Akira, Katoh, Takaaki, Kikuchi, Jyunko, Kudo, Takashi, Minagawa, Kazuyuki, Mori, Kohji, Morihara, Takashi, Nakano, Yuko, Nakayama, Taisuke, Nishigaki, Atsuko, Nishimura, Masaki, Nishitomi, Kouhei, Okochi, Masayasu, Sakaguchi, Gaku, Tagami, Shinji, Takeda, Masatoshi, Takemoto, Hiroshi, Takinami, Yoshihiko, Tanaka, Toshihisa, Willem, Michael, Yanagida, Kanta   +27 more
core   +1 more source

Phosphate‐ and pH‐dependent self‐assembly of recombinant spider silk proteins

Protein Science, Volume 35, Issue 5, May 2026.
Abstract The process of molecular self‐assembly is an omnipresent mechanism in nature to generate a variety of efficient and functional hierarchical architectures, and inspires tailored material design and development. Thereby, self‐assembly is based on a controlled interplay and association of monomers into highly ordered structures triggered by ...
Vanessa T. Trossmann, Veronika Hovanová, Tim Schiller, Martin Humenik, Erik Sedlák, Thomas R. Scheibel   +5 more
wiley   +1 more source

The Large Ectodomain of APP Prevents APP from being Directly Cleaved by γ-Secretase

Frontiers in Bioscience-Landmark
Background: Alzheimer’s disease (AD) is characterized by the deposition of amyloid-β peptide (Aβ) in the brain. Aβ is produced by sequential β- and γ-secretase cleavages of amyloid precursor protein (APP).
Yuan Li, Hejie Li, Wenping Liang, Yu Li, Zhe Wang   +4 more
doaj   +1 more source

Role of Synucleins in Alzheimer’s Disease [PDF]

, 2009
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common causes of dementia and movement disorders in the elderly. While progressive accumulation of oligomeric amyloid-β protein (Aβ) has been identified as one of the central toxic events
Leslie Crews, Igor Tsigelny, Makoto Hashimoto, Eliezer Masliah, K Andra, N Arispe, N Arispe, JW Ashford, BA Bahr, P Bar-On, P Bar-On, D Borchelt, D Borchelt, KD Bornemann, C Bouillot, H Braak, DE Cabin, H Cai, S Chandra, IH Cheng, MA Chishti, M Citron, DF Clayton, KA Conway, DG Cook, JG Culvenor, KM Danzer, V Deramecourt, TT Ding, JE Duda, BM Dufty, D Eliezer, PO Fernagut, SM Fleming, DL Fortin, D Games, D Games, BI Giasson, BI Giasson, CC Glabe, L Goldstein, RL Hamilton, L Hansen, J Hardy, T Hartmann, M Hashimoto, M Hashimoto, M Hashimoto, M Hashimoto, M Hashimoto, M Hashimoto, M Hashimoto, LE Hebert, PR Hof, P Hof, L Holcomb, K Hsiao, BT Hyman, M Ihara, A Iwai, A Iwai, A Iwai, A Iwai, CC Jao, KA Jellinger, PJ Kahle, F Kamenetz, SI Kim, D Kirik, WL Klein, RL Klein, EH Koo, S Kubo, T Kurata, PT Lansbury Jr, HA Lashuel, HA Lashuel, M Lee, MK Lee, HJ Lee, JB Leverenz, W Li, H Lin, CF Lippa, CF Lippa, SM Lippa, CF Lippa, C Lo Bianco, Y Luo, PK Mandal, E Masliah, E Masliah, E Masliah, E Masliah, E Masliah, E Masliah, MP Mattson, IG McKeith, IG McKeith, AJ Mishizen-Eberz, D Moechars, DL Moolman, L Mucke, DD Murphy, L Narhi, RA Nixon, E Perry, EK Perry, J Pettegrew, O Pletnikova, DL Price, A Quist, EK Richfield, JC Rochet, E Rockenstein, E Rockenstein, E Rockenstein, RN Rosenberg, SW Scheff, D Selkoe, DJ Selkoe, DJ Selkoe, DJ Selkoe, S Sinha, S Sinha, SS Sisodia, BJ Snider, C Soto, MG Spillantini, TL Spires, C Sturchler-Pierrat, RD Terry, JQ Trojanowski, JQ Trojanowski, JQ Trojanowski, IF Tsigelny, IF Tsigelny, K Ueda, VN Uversky, VN Uversky, H Putten van der, R Vassar, MJ Volles, R Coelln von, K Wakabayashi, K Wakabayashi, DM Walsh, R Williamson, CA Wilson, PE Wright, Y Xia, W Xia, H Xu, F Yang, M Yoshimoto, M Zhu   +155 more
core   +2 more sources

EN2 Regulates Pancreatic Cancer Initiation, Progression, and Epithelial‐Mesenchymal Transition Through the Notch Signalling Pathway

Journal of Cellular and Molecular Medicine, Volume 30, Issue 9, May 2026.
ABSTRACT The incidence and mortality of pancreatic cancer are steadily increasing worldwide, and the disease is projected to become the second leading cause of cancer‐related deaths by 2030. Pancreatic tumorigenesis is driven by multiple genetic alterations, underscoring the need to elucidate the molecular mechanisms underlying pancreatic ...
Wei Yu, Raj K. Varma, Yiming Ma, Varun Chandra Boinpelly, Areej Khatri, Emma Gombos, Rakesh K. Srivastava, Sharmila Shankar   +7 more
wiley   +1 more source

A novel BACE inhibitor isolated from Eisenia bicyclis exhibits neuroprotective activity against β-amyloid toxicity

Fisheries and Aquatic Sciences, 2018
Alzheimer’s disease (AD) is a disturbing and advanced neurodegenerative disease and is characterized pathologically by the accumulation of amyloid beta (Aβ) and the hyperphosphorylation of tau proteins in the brain.
Jung Kwon Lee, Hee-Guk Byun
doaj   +1 more source