Results 121 to 130 of about 27,905 (224)

Development of Potential Multi-Target Inhibitors for Human Cholinesterases and Beta-Secretase 1: A Computational Approach. [PDF]

Pharmaceuticals (Basel), 2023
Barbosa DB, do Bomfim MR, de Oliveira TA, da Silva AM, Taranto AG, Cruz JN, de Carvalho PB, Campos JM, Santos CBR, Leite FHA.   +9 more
europepmc   +1 more source

Review of Various Approaches to Alzheimer's Disease Treatment Have Focused Solely on ß-Secretase (BACE) As A Ligand’s Target in the Last Two Decades [PDF]

SINAI International Scientific Journal
AD is the most common type of dementia, characterized by advancing memory deterioration that ultimately leads to the complete loss of intellectual and mental abilities leading to loss of the ability to carry on a conversation and respond to the ...
Mo’men A. Salem, Mennah M. Abd El Wahab   +1 more
doaj   +1 more source

Beta-Secretase 1 Recruits Amyloid-Beta Precursor Protein to ROCK2 Kinase, Resulting in Erroneous Phosphorylation and Beta-Amyloid Plaque Formation. [PDF]

Int J Mol Sci, 2023
Hajdú I, Végh BM, Szilágyi A, Závodszky P.   +3 more
europepmc   +1 more source

Beta-Secretase-1 Antisense RNA Is Associated with Vascular Ageing and Atherosclerotic Cardiovascular Disease. [PDF]

Thromb Haemost, 2022
Bampatsias D, Mavroeidis I, Tual-Chalot S, Vlachogiannis NI, Bonini F, Sachse M, Mavraganis G, Mareti A, Kritsioti C, Laina A, Delialis D, Ciliberti G, Sopova K, Gatsiou A, Martelli F, Georgiopoulos G, Stellos K, Stamatelopoulos K.   +17 more
europepmc   +1 more source

Exploring the Benzazoles Derivatives as Pharmacophores for AChE, BACE1, and as Anti-Aβ Aggregation to Find Multitarget Compounds against Alzheimer’s Disease

Molecules
Despite the great effort that has gone into developing new molecules as multitarget compounds to treat Alzheimer’s disease (AD), none of these have been approved to treat this disease.
Martha Cecilia Rosales Hernández, Marycruz Olvera-Valdez, Jazziel Velazquez Toledano, Jessica Elena Mendieta Wejebe, Leticia Guadalupe Fragoso Morales, Alejandro Cruz   +5 more
doaj   +1 more source

SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells. [PDF]

Biochem Biophys Res Commun, 2022
Choi JY, Park JH, Jo C, Kim KC, Koh YH.
europepmc   +1 more source

Neuronal Aquaporin 1 Inhibits Amyloidogenesis by Suppressing the Interaction Between Beta-Secretase and Amyloid Precursor Protein. [PDF]

J Gerontol A Biol Sci Med Sci, 2021
Park J, Madan M, Chigurupati S, Baek SH, Cho Y, Mughal MR, Yu A, Chan SL, Pattisapu JV, Mattson MP, Jo DG.   +10 more
europepmc   +1 more source

Neuroactive venom compounds obtained from Phlogiellus bundokalbo as potential leads for neurodegenerative diseases: insights on their acetylcholinesterase and beta-secretase inhibitory activities in vitro. [PDF]

J Venom Anim Toxins Incl Trop Dis, 2021
Lopez SMM, Aguilar JS, Fernandez JBB, Lao AGJ, Estrella MRR, Devanadera MKP, Ramones CMV, Villaraza AJL, Guevarra LA, Santiago-Bautista MR, Santiago LA, Santiago LA.   +11 more
europepmc   +1 more source

Beta-Secretase 2 [PDF]

, 2020
openaire   +1 more source

Biological evaluation and molecular Docking studies of the prepared chalcone derivatives as potential anti-Alzheimer agents

Scientific Reports
Alzheimer’s disease (AD) is a neurological disorder characterized by memory loss, language difficulties, and the loss of planning and coordination skills.
E. N. Agbo, B. K. Maluleke, S. Gildenhuys, T. C. Leboho, W. Nxumalo   +4 more
doaj   +1 more source