Results 111 to 120 of about 27,905 (224)
Amyloid proteotoxicity initiates an inflammatory response blocked by cannabinoids. [PDF]
, 2016 The beta amyloid (Aβ) and other aggregating proteins in the brain increase with age and are frequently found within neurons. The mechanistic relationship between intracellular amyloid, aging and neurodegeneration is not, however, well understood.
Currais, Antonio +5 more
core +2 more sources
alpha- and beta-secretase: profound changes in Alzheimer's disease.
Biochemical and biophysical research communications, 2003 The amyloid plaque, a neuropathological hallmark of Alzheimer's disease, is produced by the deposition of beta-amyloid (Abeta) peptide, which is cleaved from Amyloid Precursor Protein (APP) by the enzyme beta-secretase. Only small amounts of Abeta form in normal brain; more typically this is precluded by the processing of APP by alpha-secretase.
Tyler, SJ +3 more
openaire +3 more sources
Differential regulation of BACE1 expression by oxidative and nitrosative signals [PDF]
, 2011 NIH [R01 NS054880, AG031893, R01 AG021173, R01 NS046673, R01 AG030197]; Alzheimer's Association; American Health Assistance Foundation; Alzheimer's association San Diego/Imperial ChapterBackground: It is well established that both cerebral hypoperfusion ...
Kwak, Y. D. +6 more
core +3 more sources
, 2005 Considerable insight into the functional activity of proteins and enzymes can be obtained by studying the low-energy conformational distortions that the biopolymer can sustain. We carry out the characterization of these large scale structural changes for
Amadei A +16 more
core +1 more source
Clinical Features of Rapidly Progressive Alzheimer's Disease [PDF]
, 2010 Objective: To characterize clinical features, CSF biomarkers and genetic polymorphisms of patients suffering from a rapidly progressing subtype of Alzheimer's dementia (rpAD).
Ahsen, Nico von +7 more
core +1 more source
SIRT3 activator Honokiol attenuates β-Amyloid by modulating amyloidogenic pathway.
PLoS ONE, 2018 Honokiol (poly-phenolic lignan from Magnolia grandiflora) is a Sirtuin-3 (SIRT3) activator which exhibit antioxidant activity and augment mitochondrial functions in several experimental models.
Sindhu Ramesh +11 more
doaj +1 more source
Neuronal human BACE1 knock-in induces systemic diabetes in mice [PDF]
, 2016 Acknowledgements The authors thank S. Tammireddy (Diabetes and Cardiovascular Science, University of the Highlands and Islands, Inverness, UK) for technical support with the lipidomics component. Funding We would like to thank R.
Dekeryte, Ruta +12 more
core +4 more sources
Journal of Medicinal Chemistry, 2016 A growing subset of β-secretase (BACE1) inhibitors for the treatment of Alzheimer's disease (AD) utilizes an anilide chemotype that engages a key residue (Gly230) in the BACE1 binding site. Although the anilide moiety affords excellent potency, it simultaneously introduces a third hydrogen bond donor that limits brain availability and provides a ...
Christopher R. Butler +22 more
openaire +2 more sources
BMC Neuroscience, 2011 Background Berberine (BER), the major alkaloidal component of Rhizoma coptidis, has multiple pharmacological effects including inhibition of acetylcholinesterase, reduction of cholesterol and glucose levels, anti-inflammatory, neuroprotective and ...
Zhu Feiqi +6 more
doaj +1 more source
Molecules, 2019 BACE1 inhibitory conjugates derived from two natural products, luteolin (1) and p-hydroxy-cinnamic acid (2), were subjected to systematic structure modifications, including various positions in luteolin segment for conjugation, different linkers (length,
De-Yang Sun +4 more
doaj +1 more source