Results 11 to 20 of about 323,586 (342)

Specific domain V reduction of beta-2-glycoprotein I induces protein flexibility and alters pathogenic antibody binding [PDF]

Scientific Reports, 2021
Beta-2-glycoprotein I (β2GPI) is a blood protein and the major antigen in the autoimmune disorder antiphospholipid syndrome (APS). β2GPI exists mainly in closed or open conformations and comprises of 11 disulfides distributed across five domains.
Ina Buchholz, Thomas McDonnell, Peter Nestler, Sudarat Tharad, Martin Kulke, Anna Radziszewska, Vera M. Ripoll, Frank Schmidt, Elke Hammer, Jose L. Toca-Herrera, Anisur Rahman, Mihaela Delcea   +11 more
doaj   +3 more sources

The Significance of Anti-Beta-2-Glycoprotein I Antibodies in Antiphospholipid Syndrome [PDF]

Antibodies, 2016
Antiphospholipid syndrome (APS) is a thrombophilic disorder that classically presents with vascular thrombosis and/or obstetric complications. APS is associated with antiphospholipid antibodies: a heterogeneous group of autoantibodies that are directed ...
Anna Brusch
doaj   +3 more sources

PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome [PDF]

Frontiers in Immunology, 2018
APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I (DI).
Thomas C. R. McDonnell, Rohan Willis, Charis Pericleous, Vera M. Ripoll, Ian P. Giles, David. A. Isenberg, David. A. Isenberg, Allan R. Brasier, Emilio B. Gonzalez, Elizabeth Papalardo, Zurina Romay-Penabad, Mohammad Jamaluddin, Yiannis Ioannou, Yiannis Ioannou, Anisur Rahman   +14 more
doaj   +3 more sources

Anticardiolipin Antibodies Recognize β(2)-Glycoprotein I Structure Altered by Interacting with an Oxygen Modified Solid Phase Surface [PDF]

Journal of Experimental Medicine, 1994
Anticardiolipin antibodies (aCL) derived from the sera of individuals exhibiting the antiphospholipid syndrome (APS) directly bind to beta(2)-glycoprotein I (beta(2)-GPI), which is adsorbed to an oxidized polystyrene surface. Oxygen atoms were introduced
Igarashi, Yoshiko, Koike, Takao, Matsuura, Eiji, Triplett, Douglas A., Yasuda, Tatsuji   +4 more
core   +4 more sources

The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS.

Blood Rev, 2020
McDonnell T, Wincup C, Buchholz I, Pericleous C, Giles I, Ripoll V, Cohen H, Delcea M, Rahman A.   +8 more
europepmc   +3 more sources

Lysine residues control the conformational dynamics of beta 2-glycoprotein I [PDF]

Physical Chemistry Chemical Physics, 2018
We report on a strategy to permanently open up the closed conformation of soluble blood protein beta 2-glycoprotein I by chemical acetylation of lysine residues.
Ina Buchholz, Peter Nestler, Susan Köppen, Mihaela Delcea   +3 more
semanticscholar   +6 more sources

Pretransplant IgA-Anti-Beta 2 Glycoprotein I Antibodies As a Predictor of Early Graft Thrombosis after Renal Transplantation in the Clinical Practice: A Multicenter and Prospective Study. [PDF]

Front Immunol, 2018
Background Graft thrombosis is a devastating complication after renal transplantation. We recently described the association of anti-beta-2-glycoprotein-I (IgA-ab2GP1) antibodies with early graft loss mainly caused by thrombosis in a monocenter study ...
Morales JM, Serrano M, Martinez-Flores JA, Gainza FJ, Marcen R, Arias M, Escuin F, Pérez D, Andres A, Martínez MA, Maruri N, Alvarez E, Castañer JL, López-Hoyos M, Serrano A.   +14 more
europepmc   +4 more sources

Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit: a prospective cohort study [PDF]

Critical Care, 2020
No abstract available Keywords: Apolipoprotein H; B2GPI; Biomarkers; Critical care; ICU; SIRS; Sepsis.
Irene T. Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu, Dylan W. de Lange   +4 more
doaj   +3 more sources

Pathogenesis of the obstetric antiphospholipid syndrome: the key role of beta 2 glycoprotein I [PDF]

Exploration of Immunology, 2022
Antiphospholipid syndrome (APS) is defined by recurrent pregnancy morbidity and/or vascular thrombosis associated with the persistent presence of antibodies against anionic phospholipid-binding proteins. Beta 2 glycoprotein I (β2GPI) and prothrombin (PT)
Pier Luigi Meroni, Claudia Grossi, Francesco Tedesco   +2 more
doaj   +2 more sources

Beyond antibodies: Beta-2 glycoprotein I as the unsung guardian of pregnancy. [PDF]

PLoS ONE
The physiological function of beta 2 glycoprotein I (β2GPI) itself is not well understood, other than that it is a primary antigen to anti-phospholipid antibodies in the autoimmune disease antiphospholipid syndrome.
Kazunobu Yagi, Reina Komatsu, Hitomi Nakamura, Kazuya Mimura, Masayuki Endo, Takuji Tomimatsu, Tadashi Kimura   +6 more
doaj   +2 more sources