Anti-beta 2 glycoprotein I IgA in the SLICC classification criteria dataset. [PDF]
Lupus, 2021 Objective Anti-beta 2 glycoprotein I IgA is a common isotype of anti-beta 2 glycoprotein I in SLE. Anti-beta 2 glycoprotein I was not included in the American College of Rheumatology (ACR) SLE classification criteria, but was included in the Systemic Lupus International Collaborating Clinics (SLICC) criteria. We aimed to evaluate the prevalence of anti-
Elkhalifa M +40 more
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PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome [PDF]
Frontiers in Immunology, 2018 APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I (DI).
Thomas C. R. McDonnell +14 more
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Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome. [PDF]
Thromb J, 2016 The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages. Two major discoveries have advanced our understanding of the underlying complex pathogenesis of the APS. The first was the discovery that beta-2 glycoprotein-1 (β2GPI) is the major auto antigen in
El-Assaad F +2 more
europepmc +6 more sources
Pretransplant IgA-Anti-Beta 2 Glycoprotein I Antibodies As a Predictor of Early Graft Thrombosis after Renal Transplantation in the Clinical Practice: A Multicenter and Prospective Study [PDF]
Frontiers in Immunology, 2018 BackgroundGraft thrombosis is a devastating complication after renal transplantation. We recently described the association of anti-beta-2-glycoprotein-I (IgA-ab2GP1) antibodies with early graft loss mainly caused by thrombosis in a monocenter study ...
Jose M. Morales +25 more
doaj +3 more sources
Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit: a prospective cohort study [PDF]
Critical Care, 2020 No abstract available Keywords: Apolipoprotein H; B2GPI; Biomarkers; Critical care; ICU; SIRS; Sepsis.
Irene T. Schrijver +4 more
doaj +3 more sources
beta 2-Glycoprotein I and anti-beta 2-glycoprotein I antibodies: where are we now? [PDF]
Rheumatology, 1997 beta 2-Glycoprotein I (beta 2-GPI), a plasma protein with in vitro anticoagulant properties, has been recognized to have an important role in the antiphospholipid syndrome (APS) as a cofactor and an (co)antigen in ELISA assays. Although beta 2-GPI levels were found to be increased in some patients with APS, the clinical value of measuring beta 2-GPI ...
M Inanc
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Anti-beta 2 glycoprotein I antibodies in centenarians [PDF]
Experimental Gerontology, 2004 Non-organ-specific autoantibodies are present in centenarians without evidence of autoimmune diseases but conflicting or no data on anti-phospholipid and anti-phospholipid binding proteins were reported.To investigate the presence and antigen specificity of anti-phospholipid and anti-phospholipid binding proteins in centenarians.Seventy-seven ...
Pier Luigi Meroni +8 more
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The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury. [PDF]
PLoS ONE, 2016 Reperfusion after a period of ischemia results in reperfusion injury (IRI) which involves activation of the inflammatory cascade. In cardiac IRI, IgM natural antibodies (NAb) play a prominent role through binding to altered neoepitopes expressed on ...
Peng Zhang +10 more
doaj +2 more sources
Pathogenesis of the obstetric antiphospholipid syndrome: the key role of beta 2 glycoprotein I
Exploration of Immunology, 2022 Antiphospholipid syndrome (APS) is defined by recurrent pregnancy morbidity and/or vascular thrombosis associated with the persistent presence of antibodies against anionic phospholipid-binding proteins. Beta 2 glycoprotein I (β2GPI) and prothrombin (PT)
Pier Luigi Meroni +2 more
doaj +3 more sources
Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids [PDF]
Biochemical Journal, 1999 Considerable interest is currently focused on the interactions of beta-2 glycoprotein I (β2GPI) and anti-phospholipid antibodies with anionic phospholipids in an attempt to understand the association between these antibodies and clinical diseases such as thrombosis.
Timothy Brighton +3 more
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