Results 11 to 20 of about 206,426 (300)

Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome. [PDF]

Thromb J, 2016
The antiphospholipid syndrome (APS) is an autoimmune disease characterised by a procoagulant state that predisposes to recurrent thrombosis and miscarriages.
El-Assaad F, Krilis SA, Giannakopoulos B.   +2 more
europepmc   +7 more sources

Beta-2-glycoprotein I as a biomarker for sepsis in critically ill patients in the intensive care unit: a prospective cohort study [PDF]

Critical Care, 2020
No abstract available Keywords: Apolipoprotein H; B2GPI; Biomarkers; Critical care; ICU; SIRS; Sepsis.
Irene T. Schrijver, Hans Kemperman, Mark Roest, Jozef Kesecioglu, Dylan W. de Lange   +4 more
doaj   +3 more sources

Methodology of generation and purification of anti-beta 2 glycoprotein I antibodies [PDF]

MethodsX, 2019
In this Method Article we are showing the methodology for generation and purification of Anti-Beta 2 Glycoprotein I (β2GPI) antibodies. First β2GPI was purified from human plasma, and recognized by Western Blot and anti-β2GPI antibodies of serum from ...
Marcelo Alarcon, Eduardo Fuentes, Ximena Maldonado, Claudia Mardones, Iván Palomo   +4 more
doaj   +4 more sources

PEGylated Domain I of Beta-2-Glycoprotein I Inhibits the Binding, Coagulopathic, and Thrombogenic Properties of IgG From Patients With the Antiphospholipid Syndrome [PDF]

Frontiers in Immunology, 2018
APS is an autoimmune disease in which antiphospholipid antibodies (aPL) cause vascular thrombosis and pregnancy morbidity. In patients with APS, aPL exert pathogenic actions by binding serum beta-2-glycoprotein I (β2GPI) via its N-terminal domain I (DI).
Thomas C. R. McDonnell, Rohan Willis, Charis Pericleous, Vera M. Ripoll, Ian P. Giles, David. A. Isenberg, David. A. Isenberg, Allan R. Brasier, Emilio B. Gonzalez, Elizabeth Papalardo, Zurina Romay-Penabad, Mohammad Jamaluddin, Yiannis Ioannou, Yiannis Ioannou, Anisur Rahman   +14 more
doaj   +3 more sources

The role of beta-2-glycoprotein I in health and disease associating structure with function: More than just APS.

Blood Rev, 2020
McDonnell T, Wincup C, Buchholz I, Pericleous C, Giles I, Ripoll V, Cohen H, Delcea M, Rahman A.   +8 more
europepmc   +3 more sources

Renal Transplantation Dramatically Reduces IgA Anti-beta-2-glycoprotein I Antibodies in Patients with Endstage Renal Disease [PDF]

Journal of Immunology Research, 2014
IgA anti-beta-2-glycoprotein I (aB2GPI) antibodies have been related to vascular pathology in the general population and mainly in hemodialyzed patients (prevalence 33%) in whom an elevated incidence of thrombosis and mortality is found. In this paper we
Manuel Serrano, Jose Angel Martínez-Flores, Maria José Castro, Florencio García, David Lora, Dolores Pérez, Esther Gonzalez, Estela Paz-Artal, Jose M. Morales, Antonio Serrano   +9 more
doaj   +4 more sources

Pathogenesis of the obstetric antiphospholipid syndrome: the key role of beta 2 glycoprotein I [PDF]

Exploration of Immunology, 2022
Antiphospholipid syndrome (APS) is defined by recurrent pregnancy morbidity and/or vascular thrombosis associated with the persistent presence of antibodies against anionic phospholipid-binding proteins. Beta 2 glycoprotein I (β2GPI) and prothrombin (PT)
Pier Luigi Meroni, Claudia Grossi, Francesco Tedesco   +2 more
doaj   +2 more sources

Anti-beta 2 glycoprotein I IgA in the SLICC classification criteria dataset. [PDF]

Lupus, 2021
Objective Anti-beta 2 glycoprotein I IgA is a common isotype of anti-beta 2 glycoprotein I in SLE. Anti-beta 2 glycoprotein I was not included in the American College of Rheumatology (ACR) SLE classification criteria, but was included in the Systemic ...
Elkhalifa M, Orbai AM, Magder LS, Petri M, Alarcón GS, Gordon C, Merrill J, Fortin PR, Bruce IN, Isenberg D, Wallace D, Nived O, Ramsey-Goldman R, Bae SC, Hanly JG, Sanchez-Guerrero J, Clarke AE, Aranow C, Manzi S, Urowitz M, Gladman DD, Kalunian K, Werth VP, Zoma A, Bernatsky S, Khamashta M, Jacobsen S, Buyon JP, Dooley MA, Vollenhoven RV, Ginzler E, Stoll T, Peschken C, Jorizzo JL, Callen JP, Lim S, Inanc M, Kamen DL, Rahman A, Steinsson K, Franks AG.   +40 more
europepmc   +2 more sources

Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps. [PDF]

Clin Immunol, 2023
Kmeťová K, Lonina E, Yalavarthi S, Levine JS, Hoy CK, Sarosh C, Gockman K, Morris AE, Tambralli A, Madison JA, Zuo Y, Subang R, Rauch J, Knight JS.   +13 more
europepmc   +2 more sources

The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury. [PDF]

PLoS ONE, 2016
Reperfusion after a period of ischemia results in reperfusion injury (IRI) which involves activation of the inflammatory cascade. In cardiac IRI, IgM natural antibodies (NAb) play a prominent role through binding to altered neoepitopes expressed on ...
Peng Zhang, James C Weaver, Gang Chen, Julia Beretov, Tatsuya Atsumi, Miao Qi, Ravinay Bhindi, Jian C Qi, Michele C Madigan, Bill Giannakopoulos, Steven A Krilis   +10 more
doaj   +2 more sources