The Fifth Domain of Beta 2 Glycoprotein I Protects from Natural IgM Mediated Cardiac Ischaemia Reperfusion Injury. [PDF]
PLoS ONE, 2016 Reperfusion after a period of ischemia results in reperfusion injury (IRI) which involves activation of the inflammatory cascade. In cardiac IRI, IgM natural antibodies (NAb) play a prominent role through binding to altered neoepitopes expressed on ...
Peng Zhang +10 more
doaj +2 more sources
Gram Negative Bacterial Inflammation Ameliorated by the Plasma Protein Beta 2-Glycoprotein I. [PDF]
Sci Rep, 2016 Lipopolysaccharide (LPS) is a major component of the outer wall of gram negative bacteria. In high doses LPS contributes to the inflammation in gram negative sepsis and in low doses contributes to the low grade inflammation characteristic of the ...
Zhou S +11 more
europepmc +4 more sources
Interference of lupus anticoagulant causing antiprothrombin and anti–beta-2-glycoprotein I antibodies on international normalized ratio measurements: comparative analysis of international normalized ratio methods [PDF]
Research and Practice in Thrombosis and HaemostasisBackground: Life-long vitamin K antagonist (VKA) therapy is recommended as a standard of care in antiphospholipid syndrome (APS) patients with thrombosis.
Rachel Gehlen +7 more
doaj +2 more sources
In vivo modulation of angiogenesis by beta 2 glycoprotein I [PDF]
Journal of Autoimmunity, 2010 Beta 2 glycoprotein I (β2GPI) is the major auto antigen in the antiphospholipid syndrome but also interacts with fibrinolytic and angiogenic proteins. The aim of this study was to examine the angiogenic potential of β2GPI in vivo in β2GPI deficient mice utilizing angiogenic assays. β2GPI deficient mice show increased microvessel formation in comparison
Passam, F.H +4 more
openaire +5 more sources
Interaction of the antiphospholipid syndrome autoantigen beta-2 glycoprotein I with DNA and neutrophil extracellular traps. [PDF]
Clin Immunol, 2023 Kmeťová K +13 more
europepmc +2 more sources
Prevalence of beta 2-glycoprotein I antibody in systemic lupus erythematosus patients with beta 2-glycoprotein I dependent antiphospholipid antibodies. [PDF]
Annals of the Rheumatic Diseases, 1995 To investigate whether beta 2-glycoprotein I antibody (aGPI) exists in sera that are positive for antiphospholipid antibodies (aPL).Thirty six patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers were recruited. GPI independent and dependent aPL (anticardiolipin (aCL), antiphosphatidylserine, antiphosphatidylinositol ...
J, Matsuda +4 more
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Cardiolipin interacts with beta-2-glycoprotein I and forms an open conformation-Mechanisms analyzed using hydrogen/deuterium exchange. [PDF]
Protein Sci, 2021 Beta‐2‐glycoprotein I (β2GPI) is the major antigen for the antiphospholipid antibodies in the antiphospholipid syndrome. The exposed epitope in domain I of β2GPI can be recognized by the anti‐β2GPI antibody.
Tang KT, Wu TY, Chen HH, Lin CC, Hsu YH.
europepmc +2 more sources
Anticardiolipin and anti-beta-2 glycoprotein I antibodies in patients with moderate or severe COVID-19. [PDF]
Am J Med Sci, 2023 Garcia-Arellano G +7 more
europepmc +2 more sources
Anticardiolipin and anti-beta 2-glycoprotein I antibodies in patients with unexplained articular manifestations. [PDF]
J Clin Lab Anal, 2023 Melayah S +3 more
europepmc +3 more sources
Posttranslational forms of beta 2-glycoprotein I in the pathogenesis of the antiphospholipid syndrome. [PDF]
Thromb J, 2016 El-Assaad F +2 more
europepmc +3 more sources