Microheterogeneity of beta-2 glycoprotein I: implications for binding to anionic phospholipids [PDF]
Considerable interest is currently focused on the interactions of beta-2 glycoprotein I (β2GPI) and anti-phospholipid antibodies with anionic phospholipids in an attempt to understand the association between these antibodies and clinical diseases such as thrombosis.
Timothy Brighton +3 more
openalex +4 more sources
Prevalence of beta 2-glycoprotein I antibody in systemic lupus erythematosus patients with beta 2-glycoprotein I dependent antiphospholipid antibodies. [PDF]
To investigate whether beta 2-glycoprotein I antibody (aGPI) exists in sera that are positive for antiphospholipid antibodies (aPL).Thirty six patients with systemic lupus erythematosus (SLE) and 20 healthy volunteers were recruited. GPI independent and dependent aPL (anticardiolipin (aCL), antiphosphatidylserine, antiphosphatidylinositol ...
J Matsuda +4 more
openalex +4 more sources
The use of ionic metals such as zinc (Zn2+) is providing promising results in regenerative medicine. In this study, human keratinocytes (HaCaT cells) were treated with different concentrations of zinc chloride (ZnCl2), ranging from 1 to 800 µg/mL, for 3,
Beatriz Salesa +2 more
doaj +1 more source
Anti-beta 2 glycoprotein I antibodies in centenarians [PDF]
Non-organ-specific autoantibodies are present in centenarians without evidence of autoimmune diseases but conflicting or no data on anti-phospholipid and anti-phospholipid binding proteins were reported.To investigate the presence and antigen specificity of anti-phospholipid and anti-phospholipid binding proteins in centenarians.Seventy-seven ...
Meroni P. L. +8 more
openaire +5 more sources
In vivo modulation of angiogenesis by beta 2 glycoprotein I [PDF]
Beta 2 glycoprotein I (β2GPI) is the major auto antigen in the antiphospholipid syndrome but also interacts with fibrinolytic and angiogenic proteins. The aim of this study was to examine the angiogenic potential of β2GPI in vivo in β2GPI deficient mice utilizing angiogenic assays. β2GPI deficient mice show increased microvessel formation in comparison
Passam, F.H +4 more
openaire +3 more sources
Dimers of β2-Glycoprotein I Mimic thein Vitro Effects of β2-Glycoprotein I-Anti-β2-glycoprotein I Antibody Complexes [PDF]
Anti-beta(2)-glycoprotein I antibodies are thought to cause lupus anticoagulant activity by forming bivalent complexes with beta(2)-glycoprotein I (beta(2)GPI). To test this hypothesis, chimeric fusion proteins were constructed of the dimerization domain (apple 4) of factor XI and beta(2)GPI.
Lutters, B. C. +4 more
openaire +3 more sources
Budd-Chiari Syndrome as an Initial Presentation of Antiphospholipid Syndrome in a Male [PDF]
In Budd-Chiari Syndrome (BCS) there is narrowing and obstruction of the veins of the hepatic veins. Patients have upper quadrant abdominal pain, hepatomegaly and/or ascites.
Pusala Varun Narayana +3 more
doaj +1 more source
Thrombosis and antiphospholipid antibodies in Japanese COVID-19: based on propensity score matching
BackgroundThrombosis is a unique complication of coronavirus disease 2019 (COVID-19). Although antiphospholipid antibodies (aPL) are detected in COVID-19 patients, their clinical significance remains elusive.
Seiya Oba +18 more
doaj +1 more source
Complete amino acid sequence of human plasma beta 2-glycoprotein I.
Jay N. Lozier +2 more
openalex +3 more sources
Morphology, biophysical properties and protein-mediated fusion of archaeosomes. [PDF]
As variance from standard phospholipids of eubacteria and eukaryotes, archaebacterial diether phospholipids contain branched alcohol chains (phytanol) linked to glycerol exclusively with ether bonds.
Vid Šuštar +7 more
doaj +1 more source

