Results 101 to 110 of about 1,179,204 (384)

Nuclear matrix elements of double beta decay from beta decay [PDF]

Phys.Lett. B607 (2005) 87-95, 2004
The evaluation of the nuclear matrix elements (NME) of the two-neutrino double beta ($2\nu\beta\beta$) decay and neutrinoless double beta ($0\nu\beta\beta$) decay using the proton-neutron quasiparticle random-phase approximation (pnQRPA) is addressed.
arxiv   +1 more source

miR-92b controls glioma proliferation and invasion through regulating Wnt/beta-catenin signaling via Nemo-like kinase.

Neuro-Oncology, 2013
BACKGROUND Nemo-like kinase (NLK) is an evolutionarily conserved protein kinase involved in Wnt/beta-catenin signaling, which has been reported to be associated with gliomagenesis.
Kun Wang, Xuan Wang, Jian Zou, An-ling Zhang, Yingfeng Wan, P. Pu, Zhengfei Song, Cong Qian, Yili Chen, Shuxu Yang, Yi-rong Wang   +10 more
semanticscholar   +1 more source

Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC

Science, 1997
Inactivation of the adenomatous polyposis coli ( APC ) tumor suppressor gene initiates colorectal neoplasia. One of the biochemical activities associated with the APC protein is down-regulation of transcriptional activation mediated by β-catenin and T cell transcription factor 4 (Tcf-4).
Bert Vogelstein, Andrew B. Sparks, Nick Barker, Vladimir Korinek, Kenneth W. Kinzler, Patrice J. Morin, Hans Clevers   +6 more
openaire   +5 more sources

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

Beta-catenin/HuR post-transcriptional machinery governs cancer stem cell features in response to hypoxia. [PDF]

PLoS ONE, 2013
Hypoxia has been long-time acknowledged as major cancer-promoting microenvironment. In such an energy-restrictive condition, post-transcriptional mechanisms gain importance over the energy-expensive gene transcription machinery.
Gabriele D'Uva, Sara Bertoni, Mattia Lauriola, Sabrina De Carolis, Annalisa Pacilli, Laura D'Anello, Donatella Santini, Mario Taffurelli, Claudio Ceccarelli, Yosef Yarden, Lorenzo Montanaro, Massimiliano Bonafé, Gianluca Storci   +12 more
doaj   +1 more source

Acute WNT signalling activation perturbs differentiation within the adult stomach and rapidly leads to tumour formation [PDF]

, 2013
A role for WNT signalling in gastric carcinogenesis has been suggested due to two major observations. First, patients with germline mutations in adenomatous polyposis coli (APC) are susceptible to stomach polyps and second, in gastric cancer, WNT ...
A Gregorieff, A Horii, A Jung, A Novak, AC de Vries, AN Milne, AT Franco, B Kim, B Tycko, C Cavard, D Athineos, D M Pritchard, DM Parkin, E Half, E Tahara, EF Chan, G Gatta, H Guillen-Ahlers, H Ireland, H Luche, H Nagase, H Oshima, H Shibata, H Watanabe, H Zhang, HC Zheng, HJ Freeman, J Cordero, J Neumann, J Parsonnet, J Woodgett, JG Forte, K Miyazawa, K Oien, KF Becker, KW Kinzler, LK Bianchi, M Crabtree, M Iida, M Nakayama, M Shitashige, M Suzuki, M Suzuki, M Torbenson, MG Smith, MP Ebert, N Barker, N Barker, N Barker, N Barker, N Barker, N Harada, N Murata-Kamiya, N Uemura, O J Sansom, O Sokolova, O Tetsu, OJ Sansom, P Blache, P Correa, P Correa, P Lauren, P Salgueiro, P Soriano, PJ Guilford, R A Ridgway, R Kemp, R Poulsom, S Garrean, S Nakatsuru, S Patel, S Patel, S Radulescu, S Segditsas, S Sekine, SC Abraham, SC Abraham, SM Przemeck, SS Ng, T Gnad, T Oda, TC He, WM Clements, WS Park, XC He, Y Miyoshi, Y Park do, Z Spicer, Z Zhao   +88 more
core   +1 more source

Pharmacological modulation of beta-catenin and its applications in cancer therapy

Journal of Cellular and Molecular Medicine, 2013
Beta‐catenin (β‐catenin) is a multifunction protein with a central role in physiological homeostasis. Its abnormal expression leads to various diseases including cancer.
R. Thakur, D. Mishra
semanticscholar   +1 more source

The dynamic role of beta-catenin in synaptic plasticity [PDF]

Neuropharmacology, 2012
In addition to its role in development and cell proliferation, β-catenin has been implicated in neuronal synapse regulation and remodeling. Here we review basic molecular and structural mechanisms of synaptic plasticity, followed by a description of the structure and function of β-catenin. We then describe a role for β-catenin in the cellular processes
Kimberly A. Maguschak, Kerry J. Ressler, Kerry J. Ressler   +2 more
openaire   +3 more sources

Long non‐coding RNAs as therapeutic targets in head and neck squamous cell carcinoma and clinical application

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) occupy an abundant fraction of the eukaryotic transcriptome and an emerging area in cancer research. Regulation by lncRNAs is based on their subcellular localization in HNSCC. This cartoon shows the various functions of lncRNAs in HNSCC discussed in this review.
Ellen T. Tran, Ruchi A. Patel, Amogh Chariyamane, Ratna B. Ray   +3 more
wiley   +1 more source

Expression of E-cadherin, beta-catenin and Ki-67 antigen and their reciprocal relationships in mammary adenocarcinomas in bitches.

Folia Histochemica et Cytobiologica, 2007
In progression of tumours, resulting from, i.e., release of cells from the parental tumour and development of metastases, expression of cell adhesion molecules (CAM) plays a significant role.
Marcin Nowak, Janusz A Madej, Piotr Dziegiel   +2 more
doaj   +1 more source