Results 191 to 200 of about 163,717 (335)

Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion

open access: yesAdvanced Science, EarlyView.
FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao   +8 more
wiley   +1 more source

E-Cadherin and Beta-Catenin Immunoexpression In Endometrioid Endometrial Carcinoma

open access: yesGlobal Journal of Medicine and Public Health
Background Endometrial carcinoma is the most common invasive cancer of female genital tract. It is classified into type 1 and type 2, of which endometrioid carcinoma belongs to type 1 endometrial carcinoma and accounts for 85% of cases ...
Anu T R   +4 more
doaj  

Spatially Resolved Multiomics Reveals Metabolic Remodeling and Autophagy Activation in Adamantinomatous Craniopharyngiomas

open access: yesAdvanced Science, EarlyView.
Multiomics integration analysis reveals the “cystic fluid–tumor cell” metabolic coupling that mediates active choline/ethanolamine uptake of tumor cells from cystic fluid and PC/PE synthesis pathways reprogramming that mediating autophagy pathway activation within ACP. ABSTRACT Adamantinomatous craniopharyngioma (ACP), a benign yet highly recurrent and
Dongting Chen   +9 more
wiley   +1 more source

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

open access: yesAdvanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li   +14 more
wiley   +1 more source

Melatonin and andrographolide synergize to inhibit the colospheroid phenotype by targeting Wnt/beta-catenin signaling. [PDF]

open access: yesJ Pineal Res, 2022
Sokolov D   +12 more
europepmc   +1 more source

Evidence for the Nucleo-Apical Shuttling of a Beta-Catenin Like Plasmodium falciparum Armadillo Repeat Containing Protein

open access: gold, 2016
Pallabi Mitra   +7 more
openalex   +2 more sources

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