Relativistic configuration-interaction density functional theory: Nonaxial effects on nuclear $ββ$ decay [PDF]
Science Bulletin 69, 2017-2020 (2024), 2023 The relativistic configuration-interaction density functional theory is developed for even-even and odd-odd nuclei and is used to predict the nuclear matrix element of the neutrinoless $\beta\beta$ ($0\nu\beta\beta$) decay in nucleus $^{76}$Ge, amongst the most promising $\beta\beta$-decay candidates.
arxiv +1 more source
The cyclin D1 gene is a target of the beta-catenin/LEF-1 pathway.
Proceedings of the National Academy of Sciences of the United States of America, 1999 beta-Catenin plays a dual role in the cell: one in linking the cytoplasmic side of cadherin-mediated cell-cell contacts to the actin cytoskeleton and an additional role in signaling that involves transactivation in complex with transcription factors of ...
M. Shtutman +6 more
semanticscholar +1 more source
Kinetics of Wnt-driven beta-catenin stabilization revealed by quantitative and temporal imaging. [PDF]
PLoS ONE, 2008 The Wnt/beta-catenin signal transduction pathway regulates a broad range of developmental processes. Aberrant activation of the Wnt pathway leads to cancer and degenerative diseases.
Rami N Hannoush
doaj +1 more source
Dickkopfs and Wnt/β-catenin signalling in liver cancer [PDF]
, 2011 Liver cancer is the fifth and seventh most common cause of cancer in men and women, respectively. Wnt/beta-catenin signalling has emerged as a critical player in both the development of normal liver as well as an oncogenic driver in hepatocellular ...
Fatima, S, Lee, NPY, Luk, JMC
core +2 more sources
Wnt/beta-catenin pathway: modulating anticancer immune response
Journal of Hematology & Oncology, 2017 Wnt/β-catenin signaling, a highly conserved pathway through evolution, regulates key cellular functions including proliferation, differentiation, migration, genetic stability, apoptosis, and stem cell renewal.
S. Pai +8 more
semanticscholar +1 more source
Predominance of beta-catenin mutations and beta-catenin dysregulation in sporadic aggressive fibromatosis (desmoid tumor) [PDF]
Oncogene, 1999 Aggressive fibromatosis (also called desmoid tumor) occurs as a sporadic lesion or as part of Familial Adenomatous Polyposis, which is caused by germ line mutations in the Adenomatous polyposis Coli (APC) gene. APC is involved in the regulation of the cellular level of beta-catenin, which is a mediator in Wnt signaling.
Catherine Li +10 more
openaire +3 more sources
Beta-catenin phosphorylated at serine 45 is spatially uncoupled from beta-catenin phosphorylated in the GSK3 domain: implications for signaling. [PDF]
PLoS ONE, 2010 C. elegans and Drosophila generate distinct signaling and adhesive forms of beta-catenin at the level of gene expression. Whether vertebrates, which rely on a single beta-catenin gene, generate unique adhesive and signaling forms at the level of protein ...
Meghan T Maher +4 more
doaj +1 more source
Alteration of Subcellular Beta Catenin Expression in Normal Mucosa Adenoma and Carcinoma in Relation to Colorectal Carcinogenesis [PDF]
, 2010 Background: Adenomatous polyposis coli (APC) gene mutation was found in up to 80% of cases of sporadic colorectal cancers and adenomas. Loss of APC protein function has been known as one of the early process in colorectal carcinogenesis. This event leads
Abineno, P. D. (Pamela) +2 more
core +1 more source
HGF/c-Met related activation of β-catenin in hepatoblastoma
Journal of Experimental & Clinical Cancer Research, 2011 Background Activation of beta-catenin is a hallmark of hepatoblastoma (HB) and appears to play a crucial role in its pathogenesis. While aberrant accumulation of the beta-catenin is a common event in HB, mutations or deletions in CTNNB1 (beta-catenin ...
Turner Clinton +6 more
doaj +1 more source
Physiological beta-catenin signaling controls self-renewal networks and generation of stem-like cells from nasopharyngeal carcinoma [PDF]
, 2013 BACKGROUND: A few reports suggested that low levels of Wnt signaling might drive cell reprogramming, but these studies could not establish a clear relationship between Wnt signaling and self-renewal networks.
Cheng, Y +7 more
core +2 more sources