Results 261 to 270 of about 2,087,290 (305)
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Current Diabetes Reviews, 2006
Beta cell replacement and regeneration therapies seem promising approaches to the treatment of insulin-dependent diabetes. The short supply in beta cells from cadaveric organ donors and the very low replication capacity of human beta cells have spurred efforts to find robust ways of (re-)generating beta cells in vitro and in vivo. In the pancreas, both
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Beta cell replacement and regeneration therapies seem promising approaches to the treatment of insulin-dependent diabetes. The short supply in beta cells from cadaveric organ donors and the very low replication capacity of human beta cells have spurred efforts to find robust ways of (re-)generating beta cells in vitro and in vivo. In the pancreas, both
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Beta cell dynamics: beta cell replenishment, beta cell compensation and diabetes
Endocrine, 2013Type 2 diabetes, characterized by persistent hyperglycemia, arises mostly from beta cell dysfunction and insulin resistance and remains a highly complex metabolic disease due to various stages in its pathogenesis. Glucose homeostasis is primarily regulated by insulin secretion from the beta cells in response to prevailing glycemia.
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2014
Type 1 diabetes results from the autoimmune-mediated destruction of insulin-secreting beta cells, leading to beta cell loss and insulin deficiency. Presentation of peptides derived from beta cell proteins to autoreactive lymphocytes is critical for the development of disease, and the list of antigens recognized is increasing. A number of these proteins
Nadine L, Dudek, Anthony W, Purcell
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Type 1 diabetes results from the autoimmune-mediated destruction of insulin-secreting beta cells, leading to beta cell loss and insulin deficiency. Presentation of peptides derived from beta cell proteins to autoreactive lymphocytes is critical for the development of disease, and the list of antigens recognized is increasing. A number of these proteins
Nadine L, Dudek, Anthony W, Purcell
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2008
Patients suffering from type 1 and type 2 diabetes exhibit a decrease in the mass of insulin-producing beta cells. Both the ability to generate and expand large amounts of transplantable beta cells and the capacity to encourage beta-cell proliferation in the patient represent potential cures for the disease. Understanding the basic cell cycle machinery
Seth J. Salpeter, Yuval Dor
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Patients suffering from type 1 and type 2 diabetes exhibit a decrease in the mass of insulin-producing beta cells. Both the ability to generate and expand large amounts of transplantable beta cells and the capacity to encourage beta-cell proliferation in the patient represent potential cures for the disease. Understanding the basic cell cycle machinery
Seth J. Salpeter, Yuval Dor
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Annals of the New York Academy of Sciences, 2009
Steady-state cell apoptosis plays an important role in maintenance of self-tolerance. Based on this notion, the use of apoptotic cells to restore self-tolerance to beta cell antigens is a rational approach to type 1 diabetes (T1D) prevention. Our previous study demonstrated that transfusion of apoptotic beta cells induced immune tolerance to beta cell ...
Chang-Qing, Xia +4 more
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Steady-state cell apoptosis plays an important role in maintenance of self-tolerance. Based on this notion, the use of apoptotic cells to restore self-tolerance to beta cell antigens is a rational approach to type 1 diabetes (T1D) prevention. Our previous study demonstrated that transfusion of apoptotic beta cells induced immune tolerance to beta cell ...
Chang-Qing, Xia +4 more
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Generation of Beta Cells from Acinar Cells
2009It is becoming increasingly clear that differentiated adult somatic cells retain the capacity to be reprogrammed into other cell types. In the case of the pancreas, a switch from an acinar to a β-cell phenotype in vitro can be induced by soluble agents, such as growth factors and cytokines.
Baeyens, Luc, Rooman, Ilse, Bouwens, Luc
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Determination of Beta-Cell Function: Ion Channel Function in Beta Cells
2012For the regulation of beta-cell function ion channels are of outstanding importance. Beta cells are specialized to convert changes in blood glucose concentration to an adequate secretory response. To achieve this, nutrient-induced alterations of electrical activity are directly coupled to changes in insulin release.
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Beta cell apoptosis in diabetes
Apoptosis, 2009Apoptosis of beta cells is a feature of both type 1 and type 2 diabetes as well as loss of islets after transplantation. In type 1 diabetes, beta cells are destroyed by immunological mechanisms. In type 2 diabetes abnormal levels of metabolic factors contribute to beta cell failure and subsequent apoptosis.
Helen E, Thomas +4 more
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1998
Insulin-dependent (type 1) diabetes mellitus (IDDM) is classified as an autoimmune disorder, since it is associated with specific autoimmunity towards the insulin-producing cells in the islets of Langerhans. The disease process that results in IDDM is not fully understood and whether it is initiated by endogenous or exogenous antigens, or a combination,
A. Plesner, Å. Lernmark
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Insulin-dependent (type 1) diabetes mellitus (IDDM) is classified as an autoimmune disorder, since it is associated with specific autoimmunity towards the insulin-producing cells in the islets of Langerhans. The disease process that results in IDDM is not fully understood and whether it is initiated by endogenous or exogenous antigens, or a combination,
A. Plesner, Å. Lernmark
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Pancreatic beta-cell somatostatin receptors
American Journal of Physiology-Endocrinology and Metabolism, 1990The characteristics of somatostatin (SRIF) receptors in rat pancreatic beta-cells were investigated using rat islets and the beta-cell line HIT-T15 (HIT). The biochemical properties of the SRIF receptors were examined with 125I-labeled des-Ala-1,Gly-2-desamino-Cys-3-[Tyr-11]- dicarba3,14-somatostatin (CGP 23996).
K, Thermos +4 more
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