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Conversion of adult pancreatic alpha-cells to beta-cells after extreme beta-cell loss.
Nature, 2010Pancreatic insulin-producing beta-cells have a long lifespan, such that in healthy conditions they replicate little during a lifetime. Nevertheless, they show increased self-duplication after increased metabolic demand or after injury (that is, beta-cell loss).
Thorel, Fabrizio +6 more
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Endothelial cells contain beta adrenoceptors
Naunyn-Schmiedeberg's Archives of Pharmacology, 1984The direct identification of beta adrenoceptors in endothelial cell cultures has not been possible until the advent of a new beta-adrenergic radioligand, [125I]iodocyanopindolol ([125I]ICYP). Using [125I]ICYP, we report the successful identification of a beta adrenoceptor in cultured bovine aortic endothelial cells. At 37 degrees C, specific binding is
S F, Steinberg +2 more
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Making new beta cells from stem cells
Seminars in Cell & Developmental Biology, 2004In 2000, Shapiro et al. provided compelling "proof of principle" data showing that the transplantation of human islets, purified from cadaveric material, could restore severely diabetic, Type 1 patients to insulin independence. This demonstration prompted renewed efforts to find an alternative and sustainable source of surrogate islet cells for cell ...
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Microtubules and Beta Cell Secretion
1973Publisher Summary This chapter presents the concept of the involvement of the microtubular-microfilamentous system in the intracellular transport of beta granules and the mechanism by which insulin is released from the beta cell. Glucose stimulates both the release and the synthesis of insulin in beta cells.
Lacy, Paul E., Malaisse, Willy
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Beta Cell Death and Protection
Annals of the New York Academy of Sciences, 2003Abstract: Type 1 diabetes is an immune‐mediated disease critically dependent upon the interaction between antigen‐presenting cells and T cells. Clearly, both CD4+ and CD8+ T cells are required, but activated CD4+ T cells are both necessary and sufficient in causing disease.
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Regeneration of pancreatic beta cells
Frontiers in Bioscience, 2008Diabetes mellitus results from inadequate mass of insulin-producing pancreatic beta cells. Type 1 diabetes is characterized by absolute loss of beta cells due to autoimmune-mediated destruction. Type 2 diabetes is characterized by relative deficiency of beta cells due to lack of compensation for insulin resistance.
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