Results 61 to 70 of about 546 (155)

Cloning, expression, and spectral analysis of mouse betatrophin

Medical Journal of the Islamic Republic of Iran, 2017
Background: Betatrophin, a novel secretory protein from liver and fatty tissues, is believed to be involved in lipid and glucose metabolism. However, its precise physiological role remains unclear. Here, we report the cloning, expression, and purification steps of mouse betatrophin in a prokaryotic system, followed by its structural analysis.
Gholami, Samaneh, Goodarzvand Chegini, Koroush, Gheibi, Nematollah, Mokhtarian, Kobra, Mohamadi, Mohsen, Falak, Reza   +5 more
openaire   +2 more sources

Circulating Betatrophin Is Strongly Increased in Pregnancy and Gestational Diabetes Mellitus. [PDF]

PLoS ONE, 2015
Betatrophin has recently been introduced as a novel hormone and promotor of beta cell proliferation and improved glucose tolerance in mouse models of insulin resistance.
Lana Kosi Trebotic, Peter Klimek, Anita Thomas, Anna Fenzl, Karoline Leitner, Stefanie Springer, Florian W Kiefer, Alexandra Kautzky-Willer   +7 more
doaj   +1 more source

Association of Serum Betatrophin with Fibroblast Growth Factor-21 in Women with Polycystic Ovary Syndrome

Endocrinology Research and Practice, 2018
Betatrophin and fibroblast growth factor-21 (FGF-21), as recently discovered members of hepatokine/adipokine family, have been proposed to be associated with some metabolic disorders in which insulin resistance plays a major role. We aimed to investigate
Seda Kahraman, Alev Eroğlu Altınova, Mehmet Muhittin Yalçın, Özlem Gülbahar, Burak Arslan, Müjde Aktürk, Nuri Çakır, Füsun Baloş Törüner   +7 more
doaj   +1 more source

Biomarkers to inform the management of polycystic ovary syndrome: A review of systematic reviews

Clinical Endocrinology, Volume 101, Issue 5, Page 535-548, November 2024.
Abstract Introduction Polycystic ovarian syndrome (PCOS) is the commonest endocrine condition affecting reproductive age women. Many biomarkers may aid assessment and management, however evidence is limited on their utility in clinical practice.
Hugo Walford, Bede Tyler, Ali Abbara, Sophie Clarke, Vikram Talaulikar, Bassel Al Wattar   +5 more
wiley   +1 more source

Advances in the Use of Biologics and Biomaterials toward the Improvement of Pancreatic Islet Graft Survival in Type 1 Diabetes

Advanced NanoBiomed Research, Volume 4, Issue 3, March 2024.
Although islet transplantation has the potential to serve as a curative treatment for type 1 diabetes, there are many hurdles to achieving long‐term islet graft survival. This review discusses the recent advances in strategies to improve islet survival function using exogenous compounds and conformal coatings as a promising tool for improving islet ...
Michael Yilma Yitayew, Marina Luginina, Maryam Tabrizian   +2 more
wiley   +1 more source

Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes.

PLoS ONE, 2016
AimExposing a fetus to hyperglycemia can increase the risk for later-life metabolic disorders. Betatrophin has been proposed as a key regulator of pancreatic beta cell proliferation and lipid regulation.
Xuemei Xie, Hongjie Gao, Shimin Wu, Yue Zhao, Caiqi Du, Guandou Yuan, Qin Ning, Kenneth McCormick, Xiaoping Luo   +8 more
doaj   +1 more source

Serum betatrophin level of newly diagnosed and chronic diabetic patients and its relationship with metabolic parameters: Betatrophin levels in diabetes

Chronic Diseases Journal, 2023
BACKGROUND: Angiopoietin-like protein 8 (ANGPTL8) that was originally called betatrophin is a novel growth factor which is mainly secreted by the liver and associated with diabetes. Hence, it can be considered as a clinical parameter for diagnosis or treatment of diabetes.
Vakili, Nadia, Hosseini, Foruzan, Ghaderi, Ebrahim, Saed, Lotfollah, Nikkhoo, Bahram, Shakiba, Nadia, Pirmoradi, Leila   +6 more
openaire   +1 more source

Relationship of valproic acid, hepatosteatosis and serum betatrophin

, 2023
Abstract Purpose:With weight gain and/or obesity, adipocytokine levels in the blood change and nonalcoholic fatty liver disease (NAFLD) develops. In this study, we aimed to evaluate how serum betatrophin and homeostasis model assessment insulin resistance (HOMA-IR) are affected in children receiving valproic acid (VPA) monotherapy and whether ...
Huriye Cetin, Turgay Cokyaman, Şenay Bengin Ertem, Hilal Şehitoğlu, Durmuş Doğan   +4 more
openaire   +1 more source

Predictive Value of Betatrophin for Determining the Cardiovascular Risks of Obese Individuals

Journal of the College of Physicians and Surgeons Pakistan, 2021
To determine cardiovascular risk factors, calculate cardiovascular risk, and the value of betatrophin, a novel biomarker in predicting the risk of cardiovascular disease (CVD) in obese individuals.Cross-sectional and descriptive study. University of Health Sciences, Kartal Dr. Lutfi Kırdar City Hospital, Turkey, from August to November 2019.
Nazli, Haciagaoglu, Huseyin, Cetin, Ozlem, Hurmeydan, Engin Ersin, Simsek   +3 more
openaire   +3 more sources

Circulating Betatrophin Levels and Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis.

PLoS ONE, 2017
ObjectiveThe association between circulating betatrophin levels and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking betatrophin to GDM for a comprehensive understanding ...
Fei-Juan Kong, Lei-Lei Ma, Ge Li, Yi-Xin Chen, Jia-Qiang Zhou   +4 more
doaj   +1 more source