Results 51 to 60 of about 814 (180)

Betatrophin [PDF]

Islets, 2014
Regenerative therapy in diabetes with the capacity to reconstitute a functional β-cell mass sufficient for glycemic control holds the promise to effectively prevent the development of devastating late complications due to the unique ability of the β-cell to sense and regulate blood-glucose levels.
Ahnfelt-Rønne, Jonas, Madsen, Ole D
openaire   +2 more sources

Betting on betatrophin [PDF]

Science-Business eXchange, 2013
Researchers at Harvard have discovered a hormone that promotes pancreatic islet β cell proliferation in mice. Partner companies Evotec and Johnson & Johnson have rights to the molecule and plan to turn it into a preclinical type 2 diabetes candidate this year.
openaire   +1 more source

Betatrophin Acts as a Diagnostic Biomarker in Type 2 Diabetes Mellitus and Is Negatively Associated with HDL-Cholesterol

International Journal of Endocrinology, 2015
Objective. By assessing its circulating concentrations in type 2 diabetes mellitus (T2DM) patients, we aimed to explore the associations of betatrophin with various metabolic parameters and evaluate its diagnostic value in T2DM. Methods.
Min Yi, Rong-ping Chen, Rui Yang, Xian-feng Guo, Jia-chun Zhang, Hong Chen   +5 more
doaj   +1 more source

Decrease in fasting insulin secretory function correlates with significant liver fibrosis in Japanese non‐alcoholic fatty liver disease patients

JGH Open, Volume 4, Issue 5, Page 929-936, October 2020., 2020
Japanese patients with NAFLD have significant fibrosis with reduced insulin secretion. These patients also tended to be significantly non‐obese. Abstract Background and Aim Non‐alcoholic fatty liver disease (NAFLD) is typically associated with metabolic syndrome and diabetes, and insulin resistance is involved in its pathogenesis.
Norimasa Araki, Hirokazu Takahashi, Ayako Takamori, Yoichiro Kitajima, Hideyuki Hyogo, Yoshio Sumida, Saiyu Tanaka, Keizo Anzai, Shinichi Aishima, Kazuaki Chayama, Kazuma Fujimoto, Yuichiro Eguchi   +11 more
wiley   +1 more source

Variation in Circulating Betatrophin/ ANGPTL8 Levels in Normal and Overweight/Obese Pregnant Women [PDF]

Journal of Clinical and Diagnostic Research, 2019
Introduction: Betatrophin as hepatokine and adipokine influences glucose homeostasis and implicates in the pathophysiological process of obesity and pregnancy.
Mohammad Ahmad Hamza, Yassar Yahya AL Tamer, Omar Abdul Majeed AL-Habib   +2 more
doaj   +1 more source

Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses--A Case-Control Study.

PLoS ONE, 2015
PurposePrevious researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in
Ting Gao, Kairui Jin, Peihong Chen, Hua Jin, Lili Yang, Xinmiao Xie, Meili Yang, Cheng Hu, Xuemei Yu   +8 more
doaj   +1 more source

Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders

BMC Endocrine Disorders, 2020
Background The relationship between betatrophin/ANGPTL8 and obesity has been investigated using body mass index (BMI); however, since BMI reflects overall adiposity rather than body fat distribution, it remains unclear whether fat deposition in different
Jing Zheng, Juan Liu, Beverly S. Hong, Weijian Ke, Minmin Huang, Yanbing Li   +5 more
doaj   +1 more source

The ANGPTL8 rs2278426 (C/T) Polymorphism Is Associated with Prediabetes and Type 2 Diabetes in a Han Chinese Population in Hebei Province

International Journal of Endocrinology, Volume 2020, Issue 1, 2020., 2020
Background. Our aim was to investigate the association between the genetics of the angiopoietin protein‐like 8 (ANGPTL8) rs2278426 (C/T) polymorphism with prediabetes (pre‐DM) and type 2 diabetes (T2DM) in a Han Chinese population in Hebei Province, China. Methods.
Guangsen Hou, Yong Tang, Luping Ren, Yunpeng Guan, Xiaoyu Hou, Guangyao Song, Pawel Grzmil   +6 more
wiley   +1 more source

Does Ramadan fasting affect glicemic control in patients with diabetes mellitus? effects of fasting on betatrophin and insulin resistance

Medicine Science, 2022
Insulin resistance, which is involved in the pathogenesis of Type 2 Diabetes (T2DM), is considered to be associated with betatrophin. Moreover, it is known that betatrophin levels may be affected by environmental factors.
Mustafa Timurkaan, Esra Suay Timurkaan, Yilmaz Aslan, Mehmet Kalayci, Hakan Ayyildiz   +4 more
doaj   +1 more source

The Impact of Psoriasis and Metabolic Syndrome on the Systemic Inflammation and Oxidative Damage to Nucleic Acids

Journal of Immunology Research, Volume 2020, Issue 1, 2020., 2020
Background. Psoriasis is a chronic systemic inflammatory disease associated with a wide range of comorbidities, including metabolic syndrome (MetS). Serum calprotectin, ANGPTL8, and oxidative damage to nucleic acids might be associated with both diseases.
Drahomira Holmannova, Lenka Borska, Ctirad Andrys, Pavel Borsky, Jan Kremlacek, Kvetoslava Hamakova, Vit Rehacek, Andrea Malkova, Tereza Svadlakova, Vladimir Palicka, Jan Krejsek, Zdenek Fiala, Lihua Duan   +12 more
wiley   +1 more source