Results 41 to 50 of about 546 (155)

Evaluation of the Circulating Betatrophin Concentration and its Possible Correlations Among Diabetic Patients with Dyslipidemia

Endocrinology Research and Practice, 2019
Objective: The circulating betatrophin levels in diabetic patients, treated with insulin or with oral hypoglycemic agents, were measured. The correlation between betatrophin levels and the glucose/lipid variables was also analyzed. Material and Methods:
Rasha M. HUSSEIN
doaj   +1 more source

Betatrophin Levels were Increased in Pregnant Women with or without Gestational Diabetes Mellitus and Associated with Beta Cell Function [PDF]

Revista Brasileira de Ginecologia e Obstetrícia, 2016
Purpose betatrophin has been reported to boost β cell expansion in insulin resistant states. Pregnancy is a well-recognized physiological state of insulin resistance.
Yun Huang, Chen Fang, Zhimin Ma, Heming Guo, Ruihua Wang, Ji Hu   +5 more
doaj   +1 more source

Insulin upregulates betatrophin expression via PI3K/Akt pathway

Scientific Reports, 2017
Betatrophin is regarded as a liver-produced hormone induced by insulin resistance (IR). However, it remains largely unknown how IR regulates betatrophin expression. To study whether IR could regulate betatrophin expression and the corresponding molecular
Puhan Lu, Xi Chen, Zeqing Zhang, Jianhua Zhang, Yan Yang, Zhelong Liu, Junhui Xie, Shiying Shao, Xinrong Zhou, Shuhong Hu, Wentao He, Jiajun Zhao, Xuefeng Yu   +12 more
doaj   +1 more source

Betatrophin [PDF]

Islets, 2014
Regenerative therapy in diabetes with the capacity to reconstitute a functional β-cell mass sufficient for glycemic control holds the promise to effectively prevent the development of devastating late complications due to the unique ability of the β-cell to sense and regulate blood-glucose levels.
Ahnfelt-Rønne, Jonas, Madsen, Ole D
openaire   +1 more source

Betatrophin Acts as a Diagnostic Biomarker in Type 2 Diabetes Mellitus and Is Negatively Associated with HDL-Cholesterol

International Journal of Endocrinology, 2015
Objective. By assessing its circulating concentrations in type 2 diabetes mellitus (T2DM) patients, we aimed to explore the associations of betatrophin with various metabolic parameters and evaluate its diagnostic value in T2DM. Methods.
Min Yi, Rong-ping Chen, Rui Yang, Xian-feng Guo, Jia-chun Zhang, Hong Chen   +5 more
doaj   +1 more source

Relationship Between Serum Betatrophin Levels and Non-alcoholic Fatty Liver Disease in Hypogonadal Males

Endocrinology Research and Practice
Objective: Betatrophin is a hepatokine that modulates hepatic glucose and lipid metabolism and contributes to non-alcoholic fatty liver disease (NAFLD) pathogenesis.
Feyza Sarışık, Ayten Oğuz, Murat Şahin, Murat İspiroğlu, Ergül B. Kurutaş, Özlem Nakış Bozkuş, Ümit Nur Özbay, Kamile Gül   +7 more
doaj   +3 more sources

Betatrophin association with serum triglyceride levels in obstructive sleep apnea patients

Annals of Thoracic Medicine, 2019
BACKGROUND: Obstructive sleep apnea (OSA) is a common sleep problem, in which patients are at increased risk for metabolic and cardiovascular problems, including metabolic syndrome, diabetes mellitus (DM), and dyslipidemia. Betatrophin is a novel protein
Bunyamin Sertogullarindan, Ahmet Ufuk Komuroglu, Rifki Ucler, Hulya Gunbatar, Aysel Sunnetcioglu, Erdem Cokluk   +5 more
doaj   +1 more source

Decrease in fasting insulin secretory function correlates with significant liver fibrosis in Japanese non‐alcoholic fatty liver disease patients

JGH Open, Volume 4, Issue 5, Page 929-936, October 2020., 2020
Japanese patients with NAFLD have significant fibrosis with reduced insulin secretion. These patients also tended to be significantly non‐obese. Abstract Background and Aim Non‐alcoholic fatty liver disease (NAFLD) is typically associated with metabolic syndrome and diabetes, and insulin resistance is involved in its pathogenesis.
Norimasa Araki, Hirokazu Takahashi, Ayako Takamori, Yoichiro Kitajima, Hideyuki Hyogo, Yoshio Sumida, Saiyu Tanaka, Keizo Anzai, Shinichi Aishima, Kazuaki Chayama, Kazuma Fujimoto, Yuichiro Eguchi   +11 more
wiley   +1 more source

Circulating Betatrophin Correlates with Triglycerides and Postprandial Glucose among Different Glucose Tolerance Statuses--A Case-Control Study.

PLoS ONE, 2015
PurposePrevious researches of betatrophin on glucose and lipids metabolism under insulin-resistant condition have reached controversial conclusions. To further identify the possible impact of betatrophin, we measured the circulating betatrophin levels in
Ting Gao, Kairui Jin, Peihong Chen, Hua Jin, Lili Yang, Xinmiao Xie, Meili Yang, Cheng Hu, Xuemei Yu   +8 more
doaj   +1 more source

Circulating betatrophin/ANGPTL8 levels correlate with body fat distribution in individuals with normal glucose tolerance but not those with glucose disorders

BMC Endocrine Disorders, 2020
Background The relationship between betatrophin/ANGPTL8 and obesity has been investigated using body mass index (BMI); however, since BMI reflects overall adiposity rather than body fat distribution, it remains unclear whether fat deposition in different
Jing Zheng, Juan Liu, Beverly S. Hong, Weijian Ke, Minmin Huang, Yanbing Li   +5 more
doaj   +1 more source