Anti proliferative and apoptotic effects on pancreatic cancer cell lines indicate new roles for ANGPTL8 (Betatrophin) [PDF]
Genetics and Molecular Biology, 2020 Despite considerable advances, the treatment of pancreatic cancer (PC) still requires much effort. Unusual regulation of the Wnt and apoptotic signaling pathways is widespread in cancer incidence.
Fatemeh Taherkhani +4 more
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Betatrophin: a hormone that controls pancreatic β cell proliferation.
Cell, 2013 Version of ...
Yi, Peng, Park, Ji Sun, Melton, Douglas
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Circulating Betatrophin Is Strongly Increased in Pregnancy and Gestational Diabetes Mellitus. [PDF]
PLoS ONE, 2015 Betatrophin has recently been introduced as a novel hormone and promotor of beta cell proliferation and improved glucose tolerance in mouse models of insulin resistance.
Lana Kosi Trebotic +7 more
doaj +4 more sources
PLoS ONE, 2017 ObjectiveThe association between circulating betatrophin levels and gestational diabetes mellitus (GDM) is controversial. The aim of our study was to systematically review available literature linking betatrophin to GDM for a comprehensive understanding ...
Fei-Juan Kong +4 more
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Circulating Betatrophin in Patients with Type 2 Diabetes: A Meta-Analysis
Journal of Diabetes Research, 2016 Objective. To investigate the association between circulating betatrophin level and type 2 diabetes mellitus (T2DM) in human. Methods. A comprehensive literature search was performed in PubMed and Embase databases to identify eligible studies assessing ...
Sheyu Li +7 more
doaj +2 more sources
Adiponectin Intervention to Regulate Betatrophin Expression, Attenuate Insulin Resistance and Enhance Glucose Metabolism in Mice and Its Response to Exercise. [PDF]
Int J Mol Sci, 2022 Aims: Adiponectin stimulates mitochondrial biogenesis through peroxisome proliferator-activated receptor-coactivator1α (PGC-1α), a major regulator of mitochondrial biogenesis, and its effect on the genesis of insulin resistance is organ ...
Guo Q, Cao S, Wang X.
europepmc +2 more sources
Study of Serum Betatrophin Level as a Biochemical Marker in Patients with Type-2 Diabetes Mellitus [PDF]
International Journal of Medical Arts, 2022 Background: Type 2diabetes mellitus [T2DM] is a global health problem with high morbidity and mortality. Betatrophin is a novel circulating protein produced by the adipose tissue and the liver.
Mona Elghaba +3 more
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Chronic Diseases Journal, 2022 BACKGROUND: Angiopoietin-like protein 8 (ANGPTL8) that was originally called betatrophin is a novel growth factor which is mainly secreted by the liver and associated with diabetes.
Leila Pirmoradi, Ebrahim Ghaderi
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Perspectives on the Activities of ANGPTL8/Betatrophin [PDF]
Cell, 2014 In this issue of Cell, Gusarova et al. (2014) show that deletion of ANGPTL8 in mice does not affect the compensatory proliferation of pancreatic beta cells in response to insulin resistance induced by a high-fat diet or treatment with the insulin antagonist S961. They also show that overexpression of human ANGPTL8 in mouse liver leads to elevated serum
Yi, Peng +2 more
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An Analysis of Circulating Betatrophin Levels in Relation with Type1 and Type2 Diabetes Mellitu Running Title: Betatrophin and Diabetes [PDF]
Annals of Endocrinology and Metabolism, 2021 Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Previous researches of betatrophin on glucose and lipid metabolism were mainly done under insulin resistant conditions. Only three studies from two centers investigated the association between betatrophin and type1 diabetes mellitus
Altunoglu Esma +4 more
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