Results 21 to 30 of about 546 (155)

Relationship of Serum Betatrophin with Nonalcoholic Fatty Liver in a Chinese Population.

PLoS ONE, 2017
ObjectiveThis study aimed to investigate the association of serum betatrophin with the status and progression of nonalcoholic fatty liver disease (NAFLD).MethodsA total of 249 subjects who received ultrasonic examination of liver fat content (LFC) were ...
Wen Hu, Xiaojuan Shao, Dianxuan Guo, Hairong Hao, Yong Zhang, Mingfeng Xia, Yingyun Gong, Hongwen Zhou, Yunqing Fan, Weinan Yu   +9 more
doaj   +3 more sources

Increased Circulating Betatrophin Concentrations in Patients with Type 2 Diabetes [PDF]

International Journal of Endocrinology, 2014
Betatrophin has recently been described as a key hormone to stimulate beta-cell mass expansion in response to insulin resistance and obesity in mice. The finding has generated an interest in the development of antidiabetic drugs with betatrophin as the ...
Daniel Espes, Mats Martinell, Per-Ola Carlsson   +2 more
doaj   +5 more sources

Anti proliferative and apoptotic effects on pancreatic cancer cell lines indicate new roles for ANGPTL8 (Betatrophin) [PDF]

Genetics and Molecular Biology, 2020
Despite considerable advances, the treatment of pancreatic cancer (PC) still requires much effort. Unusual regulation of the Wnt and apoptotic signaling pathways is widespread in cancer incidence.
Fatemeh Taherkhani, Kamran Mousavi Hosseini, Sanaz Zebardast, Koorosh Goodarzvand Chegini, Nematollah Gheibi   +4 more
doaj   +2 more sources

Study of Serum Betatrophin Level as a Biochemical Marker in Patients with Type-2 Diabetes Mellitus [PDF]

International Journal of Medical Arts, 2022
Background: Type 2diabetes mellitus [T2DM] is a global health problem with high morbidity and mortality. Betatrophin is a novel circulating protein produced by the adipose tissue and the liver.
Mona Elghaba, Megahed Abouelmagd, Hamdy Marzouk, Naglaa Abbas   +3 more
doaj   +1 more source

Maternal and cord blood betatrophin (angiopoietin‐like protein 8) in pregnant women with gestational diabetes and normoglycemic controls: A systematic review, meta‐analysis, and meta‐regression

Diabetes/Metabolism Research and Reviews, Volume 39, Issue 4, May 2023., 2023
Abstract Aims This systematic review and meta‐analysis examined maternal and cord blood betatrophin levels in pregnant women with gestational diabetes mellitus (GDM) and normoglycemic controls. Material and Methods PubMed, Cochrane Library, Embase, LILACS, WangFang, and China National Knowledge Infrastructure were searched for literature from inception
Faustino R. Pérez‐López, Junhua Yuan, Manuel Sánchez‐Prieto, María T. López‐Baena, Gonzalo R. Pérez‐Roncero, Seshadri Reddy Varikasuvu   +5 more
wiley   +1 more source

Perspectives on the Activities of ANGPTL8/Betatrophin [PDF]

Cell, 2014
In this issue of Cell, Gusarova et al. (2014) show that deletion of ANGPTL8 in mice does not affect the compensatory proliferation of pancreatic beta cells in response to insulin resistance induced by a high-fat diet or treatment with the insulin antagonist S961. They also show that overexpression of human ANGPTL8 in mouse liver leads to elevated serum
Yi, Peng, Park, Ji-Sun, Melton, Douglas A.   +2 more
openaire   +2 more sources

An Analysis of Circulating Betatrophin Levels in Relation with Type1 and Type2 Diabetes Mellitu Running Title: Betatrophin and Diabetes [PDF]

Annals of Endocrinology and Metabolism, 2021
Betatrophin is a newly identified liver-derived hormone that is associated with glucose homeostasis and lipid metabolism. Previous researches of betatrophin on glucose and lipid metabolism were mainly done under insulin resistant conditions. Only three studies from two centers investigated the association between betatrophin and type1 diabetes mellitus
Altunoglu Esma, Erdenen Fusun, Aydın Seda, Koro Atakan, Uzun Hafize   +4 more
openaire   +1 more source

Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors

FEBS Letters, Volume 596, Issue 24, Page 3107-3123, December 2022., 2022
In this review, we describe endocrine disruptor (ED)‐related alterations in tissues involved in metabolic homeostasis, that is, adipose tissue, liver, pancreas, intestine and brain. We also present epigenetic effects of EDs. Finally, we propose an integrative view of multi‐organ alterations that explain how EDs can contribute to the development of ...
Kévin Bernal, Charbel Touma, Chedi Erradhouani, Talía Boronat‐Belda, Lucas Gaillard, Sara Al Kassir, Hélène Le Mentec, Corinne Martin‐Chouly, Normand Podechard, Dominique Lagadic‐Gossmann, Sophie Langouet, François Brion, Anja Knoll‐Gellida, Patrick J. Babin, Iva Sovadinova, Pavel Babica, Karine Andreau, Robert Barouki, Jan Vondracek, Paloma Alonso‐Magdalena, Etienne Blanc, Min Ji Kim, Xavier Coumoul   +22 more
wiley   +1 more source

Betatrophin.

Islets, 2015
Regenerative therapy in diabetes with the capacity to reconstitute a functional β-cell mass sufficient for glycemic control holds the promise to effectively prevent the development of devastating late complications due to the unique ability of the β-cell to sense and regulate blood-glucose levels.
Jonas, Ahnfelt-Rønne, Ole D, Madsen
openaire   +4 more sources

Review of potential biomarkers of inflammation and kidney injury in diabetic kidney disease

Diabetes/Metabolism Research and Reviews, Volume 38, Issue 6, September 2022., 2022
Abstract Diabetic kidney disease is expected to increase rapidly over the coming decades with rising prevalence of diabetes worldwide. Current measures of kidney function based on albuminuria and estimated glomerular filtration rate do not accurately stratify and predict individuals at risk of declining kidney function in diabetes.
Vuthi Khanijou, Neda Zafari, Melinda T. Coughlan, Richard J. MacIsaac, Elif I. Ekinci   +4 more
wiley   +1 more source