Insulin upregulates betatrophin expression via PI3K/Akt pathway
Scientific Reports, 2017 Betatrophin is regarded as a liver-produced hormone induced by insulin resistance (IR). However, it remains largely unknown how IR regulates betatrophin expression. To study whether IR could regulate betatrophin expression and the corresponding molecular
Puhan Lu +12 more
doaj +2 more sources
Adiponectin Intervention to Regulate Betatrophin Expression, Attenuate Insulin Resistance and Enhance Glucose Metabolism in Mice and Its Response to Exercise. [PDF]
Int J Mol Sci, 2022 Aims: Adiponectin stimulates mitochondrial biogenesis through peroxisome proliferator-activated receptor-coactivator1α (PGC-1α), a major regulator of mitochondrial biogenesis, and its effect on the genesis of insulin resistance is organ ...
Guo Q, Cao S, Wang X.
europepmc +2 more sources
Adipose Insulin Resistance and Circulating Betatrophin Levels in Women with PCOS [PDF]
BioMed Research International, Volume 2020, Issue 1, 2020., 2020 The role of IR and metabolic disorders has become a crucial topic of study in the pathogenesis of PCOS. Adipose tissue is an important target organ of insulin, and adipose IR plays an important role in the occurrence and development of PCOS. This study seeks to investigate the role of adipose IR in the development of PCOS and to examine its ...
Yirui He +6 more
wiley +3 more sources
Gender-Dependent Associations between Serum Betatrophin Levels and Lipoprotein Subfractions in Diabetic and Nondiabetic Obese Patients [PDF]
Int J Mol Sci, 2023 Betatrophin, also known as angiopoietin-like protein 8 (ANGPTL8), mainly plays a role in lipid metabolism. To date, associations between betatrophin and lipoprotein subfractions are poorly investigated.
Lőrincz H +7 more
europepmc +2 more sources
Betatrophin association with serum triglyceride levels in obstructive sleep apnea patients
Annals of Thoracic Medicine, 2019 BACKGROUND: Obstructive sleep apnea (OSA) is a common sleep problem, in which patients are at increased risk for metabolic and cardiovascular problems, including metabolic syndrome, diabetes mellitus (DM), and dyslipidemia. Betatrophin is a novel protein
Bunyamin Sertogullarindan +5 more
doaj +2 more sources
Evaluation of Betatrophin, Chemerin, and Kisspeptin Levels in Acromegaly Patients. [PDF]
Endocr Metab Immune Disord Drug TargetsBackground: Acromegaly is a chronic disorder characterized by excessive growth hormone (GH) secretion from pituitary somatotroph cells, resulting in metabolic complications and increased morbidity. Elevated levels of GH and insulin-like growth factor 1 (IGF-1) contribute to various metabolic and morphological abnormalities.
Cayan DA, Topsakal S, Avci E.
europepmc +3 more sources
Plasma and aqueous levels of subfatin, preptin and betatrophin in patients with diabetic retinopathy [PDF]
BMC Ophthalmology, 2023 Aim To examine subfatin, preptin and betatrophin levels in plasma and aqueous in patients with diabetes mellitus (DM) (with and without retinopathy). Material and method Sixty patients, who were similar in terms of age and gender, and were scheduled for ...
Sabiha Güngör Kobat +6 more
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Can Betatrophin Predict the Risk of Preeclampsia? [PDF]
Journal of Clinical and Diagnostic Research, 2018 Introduction: Preeclampsia, a hypertensive disease of pregnancy, is globally one of the primary causes of maternal morbidity and mortality. Betatrophin is shown to be a novel adipokine in pathophysiology of metabolic disorders. It plays a role in glucose
Engin Ersin Simsek +3 more
doaj +2 more sources
Residual beta-cell function in children with type 1 diabetes after a partial remission phase – a possible relation between C-peptide and betatrophin [PDF]
Frontiers in EndocrinologyIntroductionMaintaining endogenous insulin secretion in type 1 diabetes (T1D) long after its onset, and thus the need for early diagnosis and searching for factors preserving the secretory function of β-cells, has become an important goal of current ...
Emilia Odyjewska +4 more
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Relationship of Serum Betatrophin with Nonalcoholic Fatty Liver in a Chinese Population.
PLoS ONE, 2017 ObjectiveThis study aimed to investigate the association of serum betatrophin with the status and progression of nonalcoholic fatty liver disease (NAFLD).MethodsA total of 249 subjects who received ultrasonic examination of liver fat content (LFC) were ...
Wen Hu +9 more
doaj +3 more sources