Results 71 to 80 of about 1,252 (192)

Serum Betatrophin Concentrations and the Risk of Incident Diabetes: A Nested Case-Control Study from Chungju Metabolic Disease Cohort [PDF]

Diabetes & Metabolism Journal, 2017
BackgroundBetatrophin is a newly identified hormone derived from the liver and adipose tissue, which has been suggested to regulate glucose and lipid metabolism.
Seung-Hwan Lee, Marie Rhee, Hyuk-Sang Kwon, Yong-Moon Park, Kun-Ho Yoon   +4 more
doaj   +1 more source

Fasting-Mimicking Diet Promotes Ngn3-Driven β-Cell Regeneration to Reverse Diabetes [PDF]

, 2017
Stem-cell-based therapies can potentially reverse organ dysfunction and diseases, but the removal of impaired tissue and activation of a program leading to organ regeneration pose major challenges.
Buono, Roberta, Cheng, Chia-Wei, Cohen, Pinchas, Kumar, Sanjeev, Longo, Valter D., Perin, Laura, Sneddon, Julie B., Villani, Valentina, Wei, Min, Yilmaz, Omer   +9 more
core   +1 more source

Circulating Betatrophin Is Strongly Increased in Pregnancy and Gestational Diabetes Mellitus. [PDF]

PLoS ONE, 2015
Betatrophin has recently been introduced as a novel hormone and promotor of beta cell proliferation and improved glucose tolerance in mouse models of insulin resistance.
Lana Kosi Trebotic, Peter Klimek, Anita Thomas, Anna Fenzl, Karoline Leitner, Stefanie Springer, Florian W Kiefer, Alexandra Kautzky-Willer   +7 more
doaj   +1 more source

Plasma betatrophin levels in patients with liver cirrhosis

World Journal of Gastroenterology, 2015
To investigate the plasma levels of betatrophin in patients with cirrhosis.Forty patients diagnosed at the clinic with liver cirrhosis according to biological, ultrasonographic, or histological criteria were included. The severity of cirrhosis was classified according to Pugh's modification of Child's classification and MELD score.
Maria Teresa, Arias-Loste, Maria Teresa, García-Unzueta, Susana, Llerena, Paula, Iruzubieta, Angela, Puente, Joaquín, Cabezas, Carmen, Alonso, Antonio, Cuadrado, José Antonio, Amado, Javier, Crespo, Emilio, Fábrega   +10 more
openaire   +2 more sources

Biomarkers to inform the management of polycystic ovary syndrome: A review of systematic reviews

Clinical Endocrinology, Volume 101, Issue 5, Page 535-548, November 2024.
Abstract Introduction Polycystic ovarian syndrome (PCOS) is the commonest endocrine condition affecting reproductive age women. Many biomarkers may aid assessment and management, however evidence is limited on their utility in clinical practice.
Hugo Walford, Bede Tyler, Ali Abbara, Sophie Clarke, Vikram Talaulikar, Bassel Al Wattar   +5 more
wiley   +1 more source

Moderate-intensity exercise decreases the circulating level of betatrophin and its correlation among markers of obesity in women [PDF]

, 2022
Objectives Positive energy homeostasis due to overnutrition and a sedentary lifestyle triggers obesity. Obesity has a close relationship with elevated levels of betatrophin and may increase the risk of developing metabolic syndrome.
Adi Pranoto, -, Hayuris Kinandita Setiawan, -, Lilik Herawati, -, Pradika Gita Baskara, -, Purwo Sri Rejeki, -, Ronny Lesmana, -, Shariff Halim, -   +6 more
core   +1 more source

Advances in the Use of Biologics and Biomaterials toward the Improvement of Pancreatic Islet Graft Survival in Type 1 Diabetes

Advanced NanoBiomed Research, Volume 4, Issue 3, March 2024.
Although islet transplantation has the potential to serve as a curative treatment for type 1 diabetes, there are many hurdles to achieving long‐term islet graft survival. This review discusses the recent advances in strategies to improve islet survival function using exogenous compounds and conformal coatings as a promising tool for improving islet ...
Michael Yilma Yitayew, Marina Luginina, Maryam Tabrizian   +2 more
wiley   +1 more source

Increased Cord Blood Betatrophin Levels in the Offspring of Mothers with Gestational Diabetes.

PLoS ONE, 2016
AimExposing a fetus to hyperglycemia can increase the risk for later-life metabolic disorders. Betatrophin has been proposed as a key regulator of pancreatic beta cell proliferation and lipid regulation.
Xuemei Xie, Hongjie Gao, Shimin Wu, Yue Zhao, Caiqi Du, Guandou Yuan, Qin Ning, Kenneth McCormick, Xiaoping Luo   +8 more
doaj   +1 more source

Cloning, expression, and spectral analysis of mouse betatrophin

Medical Journal of the Islamic Republic of Iran, 2017
Background: Betatrophin, a novel secretory protein from liver and fatty tissues, is believed to be involved in lipid and glucose metabolism. However, its precise physiological role remains unclear. Here, we report the cloning, expression, and purification steps of mouse betatrophin in a prokaryotic system, followed by its structural analysis.
Gholami, Samaneh, Goodarzvand Chegini, Koroush, Gheibi, Nematollah, Mokhtarian, Kobra, Mohamadi, Mohsen, Falak, Reza   +5 more
openaire   +2 more sources

Relationship of valproic acid, hepatosteatosis and serum betatrophin

, 2023
Abstract Purpose:With weight gain and/or obesity, adipocytokine levels in the blood change and nonalcoholic fatty liver disease (NAFLD) develops. In this study, we aimed to evaluate how serum betatrophin and homeostasis model assessment insulin resistance (HOMA-IR) are affected in children receiving valproic acid (VPA) monotherapy and whether ...
Huriye Cetin, Turgay Cokyaman, Şenay Bengin Ertem, Hilal Şehitoğlu, Durmuş Doğan   +4 more
openaire   +1 more source