Results 71 to 80 of about 22,851 (287)

Peripheralized sepiapterin reductase inhibition as a safe analgesic therapy

Frontiers in Pharmacology, 2023
The development of novel analgesics for chronic pain in the last 2 decades has proven virtually intractable, typically failing due to lack of efficacy and dose-limiting side effects.
Shane J. F. Cronin, Nick A. Andrews, Alban Latremoliere   +2 more
doaj   +1 more source

Brain Kynurenine and BH4 Pathways: Relevance to the Pathophysiology and Treatment of Inflammation-Driven Depressive Symptoms

Frontiers in Neuroscience, 2018
The prevalence of depressive disorders is growing worldwide, notably due to stagnation in the development of drugs with greater antidepressant efficacy, the continuous large proportion of patients who do not respond to conventional antidepressants, and ...
S. Vancassel, L. Capuron, N. Castanon
semanticscholar   +1 more source

Tetrahydrobiopterin Regulates L-tyrosine-induced Elevation of Cytosolic Calcium Concentration in Insulin-secreting Cells

Pteridines, 2006
We examined the role of endogenous tetrahydrobiopterin (BH4) on L-tyrosine-induced increase in cytosolic Ca: concentration ([Ca2+],) in the ß-cell line, HIT-T15.
Ishii Masakazu, Shimizu Shunichi, Watabe Tatsuya, Kiuchi Yuji   +3 more
doaj   +1 more source

Effect of Decreased Levels of Intrinsic Tetrahydrobiopterin on Endothelial Function in Anesthetized Rats

Journal of Pharmacological Sciences, 2008
Tetrahydrobiopterin (BH4) deficiency has been suggested to be an important factor in vascular endothelial dysfunction. In this study, we investigated the influence of decreased BH4 level produced by administration of 2,4-diamino-6-hydroxypyrimidine (DAHP)
Naobumi Hamadate, Katsuhiko Noguchi, Mayuko Sakanashi, Toshihiro Matsuzaki, Junko Nakasone, Matao Sakanashi   +5 more
doaj   +1 more source

Genotypes of 2579 patients with phenylketonuria reveal a high rate of BH4 non-responders in Russia

PLoS ONE, 2019
Phenylalanine hydroxylase (PAH) deficiency is responsible for most cases of phenylketonuria (PKU). Furthermore, numerous studies on BH4-sensitive PAH deficiency have been conducted.
P. Gundorova, A. Stepanova, I. Kuznetsova, S. Kutsev, A. Polyakov   +4 more
semanticscholar   +1 more source

Hydrogen Storage Properties of Ca(BH4)(2)-LiNH2 System

, 2010
Ca(BH4)(2) is one of the promising candidates for hydrogen storage materials because of its high gravimetric and volumetric hydrogen capacity. However, its high dehydrogenation temperature and limited reversibility has been a hurdle for its practical ...
Xiong, Zhitao, Wu, Chengzhang, Zheng, Xueli, He, Teng, Chen, Ping, Wu, Guotao, Chu, Hailiang, Guo, Jianping   +7 more
core   +1 more source

Protective Effect of Tetrahydrobiopterin Against Reactive Oxygen Species- and Nitric Oxide-induced Vascular Endothelial Cell Injury

Pteridines, 2002
Vascular endothelial cells are one of the major biological targets of reactive oxygen species (ROS) in ischemiareperfusion, diabetes, hypercholesterolemia and inflammation.
Shimizu Shunichi
doaj   +1 more source

Tetrahydrobiopterin Administration Augments Exercise-Induced Hyperemia and Endothelial Function in Patients With Systemic Sclerosis

Frontiers in Medicine, 2022
Systemic sclerosis (SSc) is a rare, auto-immune disease with variably progressive fibrosis of the skin and internal organs, as well as vascular dysfunction.
Daniel R. Machin, Daniel R. Machin, Daniel R. Machin, Heather L. Clifton, D. Walter Wray, D. Walter Wray, D. Walter Wray, Tracy M. Frech, Tracy M. Frech, Anthony J. Donato, Anthony J. Donato, Anthony J. Donato, Anthony J. Donato   +12 more
doaj   +1 more source

BH4-deficient hyperphenylalaninemia in Russia

PLOS ONE, 2021
A timely detection of patients with tetrahydrobiopterin (BH4) -deficient types of hyperphenylalaninemia (HPABH4) is important for assignment of correct therapy, allowing to avoid complications. Often HPABH4 patients receive the same therapy as phenylalanine hydroxylase (PAH) -deficiency (phenylketonuria) patients—dietary treatment—and do not receive ...
Polina Gundorova, Irina A. Kuznetcova, Galina V. Baydakova, Anna A. Stepanova, Yulia S. Itkis, Victoria S. Kakaulina, Irina P. Alferova, Lidya V. Lyazina, Lilya P. Andreeva, Ilya Kanivets, Ekaterina Y. Zakharova, Sergey I. Kutsev, Aleksander V. Polyakov   +12 more
openaire   +4 more sources

Improved dehydrogenation properties of Ca(BH4)(2)-LiNH2 combined system

, 2010
Ca(BH4)(2)-LiNH2 combined system is shown to release hydrogen at much lower temperature compared to the pure Ca(BH4)(2). The improved dehydrogenation in this system can be ascribed to a combination reaction between [BH4] and [NH2] based on the reaction ...
Xiong, Zhitao, Teng He, He, Teng, Chen, Ping, Zhitao Xiong, Wu, Guotao, Chu, Hailiang, Hailiang Chu, Guotao Wu, Jianping Guo, Ping Chen, Guo, Jianping   +11 more
core   +1 more source