Results 231 to 240 of about 211,042 (267)

The Accelerated Biased Coin Up-and-Down Design in Phase I Trials

Journal of Biopharmaceutical Statistics, 2004
The biased coin up-and-down design (BCD) is used to allocate doses in phase I clinical trials. The BCD requires that the treatment response or the toxicity evaluation is observed quickly. In trials with a long treatment evaluation, the BCD will lead to long trial duration because a new patient cannot be enrolled until the preceding patient has ...
Dean Follmann
exaly   +3 more sources

Bayesian Adaptive Biased-Coin Designs for Clinical Trials with Normal Responses

Biometrics, 2005
Summary Adaptive designs are used in phase III clinical trials for skewing the allocation pattern toward the better treatments. We use optimum design theory to derive a skewed Bayesian biased‐coin procedure for sequential designs with continuous responses.
Anthony C Atkinson, Atanu Biswas
exaly   +3 more sources

Doubly adaptive biased coin designs with delayed responses

Canadian Journal of Statistics, 2008
AbstractIn clinical studies, patients are usually accrued sequentially. Response‐adaptive designs are then useful tools for assigning treatments to incoming patients as a function of the treatment responses observed thus far. In this regard, doubly adaptive biased coin designs have advantageous properties under the assumption that their responses can ...
Feifang Hu, Li-Xin Zhang, Siu Hung Cheung   +2 more
exaly   +3 more sources

Doubly adaptive biased coin designs with heterogeneous responses

Journal of Statistical Planning and Inference, 2009
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Feifang Hu
exaly   +3 more sources

Reparametrized Firth's Logistic Regressions for Dose‐Finding Study With the Biased‐Coin Design

Pharmaceutical Statistics
ABSTRACTFinding an adequate dose of the drug by revealing the dose–response relationship is very crucial and a challenging problem in the clinical development. The main concerns in dose‐finding study are to identify a minimum effective dose (MED) in anesthesia studies and maximum tolerated dose (MTD) in oncology clinical trials.
Hyungwoo Kim, Seungpil Jung, Yudi Pawitan, Woojoo Lee   +3 more
openaire   +3 more sources

A two-dimensional biased coin design for dual-agent dose-finding trials

Clinical Trials, 2015
Background: Given the limited efficacy observed with single agents, there is growing interest in Phase I clinical trial designs that allow for identification of the maximum tolerated combination of two agents.
Zhichao, Sun, Thomas M, Braun
openaire   +3 more sources

Doubly adaptive biased coin design to improve Bayesian clinical trials with time‐to‐event endpoints

Statistics in Medicine
Clinical trialists often face the challenge of balancing scientific questions with other design features, such as improving efficiency, minimizing exposure to inferior treatments, and simultaneously comparing multiple treatments. While Bayesian response adaptive randomization (RAR) is a popular and effective method for achieving these objectives, it is
Wenhao Cao, Hongjian Zhu, Li Wang, Lixin Zhang, Jun Yu   +4 more
openaire   +3 more sources

The doubly adaptive biased coin design for sequential clinical trials

Journal of Statistical Planning and Inference, 1994
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Jeffrey R. Eisele
openaire   +3 more sources

ED 90 of Intrathecal Chloroprocaine With Fentanyl for Prophylactic Cervical Cerclage: A Sequential Allocation Biased-Coin Design

Anesthesia and Analgesia, 2022
BACKGROUND: Chloroprocaine is a short-acting local anesthetic that has been used for spinal anesthesia in outpatient surgery. There is limited experience with spinal chloroprocaine for prophylactic cervical cerclage placement.
N. Sharawi, H. Tan, C. Taylor, M. Fuller, Riley Landreth, Olga I. Diomede, Matthew Williams, Caroline Martinello, J. Mhyre, A. Habib   +9 more
semanticscholar   +1 more source

The 90% minimum effective volume and concentration of ropivacaine for ultrasound-guided median nerve block in children aged 1-3 years: A biased-coin design up-and-down sequential allocation trial.

Journal of clinical anesthesia, 2022
BACKGROUND Median nerve block can provide excellent analgesia during open surgery for trigger thumb in children. However, no data on the 90% minimum effective volume (MEV90) and concentration (MEC90) of ropivacaine for ultrasound-guided median nerve ...
Wen-ming Gao, Yujiao Chen, Weiping Wang, Shangyingying Li, Lin Bai, Hong Wang, Dazhen Li, Yuan Shi, Hongzhen Xu, Shengfen Tu, Fei Yang   +10 more
semanticscholar   +1 more source